Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: Insight into the role of muscle mechanisms on cardiovascular function

Journal of Physiology

Volumn 586, Issue 9, 2008, Pages 2405-2417

  González alonso, José ^a,b   Mortensen, Stefan P ^b   Jeppesen, Tina D ^b   Ali, Leena ^c   Barker, Horace ^c   Damsgaard, Rasmus ^b   Secher, Niels H ^b   Dawson, Ellen A ^b   Dufour, Stéphane P ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c EALING HOSPITAL NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; OXYGEN;

ADULT; AEROBIC METABOLISM; ARTICLE; CARDIOVASCULAR FUNCTION; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; EXERCISE; FEMALE; FEMORAL VEIN; HEART OUTPUT; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; LEG BLOOD FLOW; LEG COMPRESSION; MALE; MEAN ARTERIAL PRESSURE; MUSCLE BLOOD FLOW; MUSCLE CONTRACTION; MUSCLE METABOLISM; NORMAL HUMAN; OXYGEN DIFFUSION; PASSIVE MOVEMENT; PRIORITY JOURNAL; SKELETAL MUSCLE; VASODILATATION; VENOUS OXYGEN TENSION; VENOUS RETURN; VOLUNTARY MOVEMENT; EXTENSOR MUSCLE; FEMORAL ARTERY; MUSCLE EXERCISE; MUSCLE PERFUSION; REST; THIGH; TISSUE OXYGENATION;

ADENOSINE TRIPHOSPHATE; ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; EXERTION; FEMALE; HEART; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MUSCLE, SKELETAL; VASOCONSTRICTION;

EID: 42949127088     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.152058     Document Type: Article

References (56)

1. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
2. Åstrand PO, Cuddy TE, Saltin B & Stenberg J (1964). Cardiac output during submaximal and maximal work. J Appl Physiol 19, 268-274.
3. Bevegård S & Lodin A (1962). Postural circulatory changes at rest and during exercise in five patients with congenital absence of valves in the deep veins of the legs. Acta Med Scand 172, 21-29.
4. Bogert LW & van Lieshout JJ (2005). Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 90, 437-446.
5. Brengelmann GL (2005). Counterpoint: The classical Guyton view that mean systemic pressure, right atrial pressure, and venous resistance govern venous return is not correct. J Appl Physiol 101, 1525-1526.
6. Clark DA, Schroeder JS, Griepp RB, Stinson EB, Dong E, Shumway NE & Harrison DC (1973). Cardiac transplantation in man. Review of first three years' experience. Am J Med 54, 563-576.
7. Clifford PS, Hamann JJ, Valic Z & Buckwalter JB (2005). Counterpoint: The muscle pump is not an important determinant of muscle blood flow during exercise. J Appl Physiol 99, 372-374.
8. Clifford PS, Klues HA, Hammann JJ, Buckwalter JB & Jasperse JL (2006). Mechanical compression elicits vasodilatation in rat skeletal muscle feed arteries. J Physiol 572, 561-567.
9. Dobson JL & Gladden LB (2003). Effect of rhythmic titanic skeletal muscle contractions on peak muscle perfusion. J Appl Physiol 94, 11-19.
10. Dufour SP, Doutreleau S, Lonsdorfer-Wolf E, Lampert E, Hirth C, Piquard F, Lonsdorfer J, Geny B, Mettauer B & Richard R (2006). Deciphering the metabolic and mechanical contributions to the exercise-induced circulatory response: Insights from eccentric cycling. Am J Physiol Regul Integr Comp Physiol 292, R1641-R1648.
11. Folkow J, Haglund U, Jodal M & Lundgren O (1971). Blood flow in the calf muscle of man during heavy rhythmic exercise. Acta Physiol Scand 80, 61-72.
12. González-Alonso J, Mortensen SP, Dawson EA, Secher NH & Damsgaard R (2006). Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: Role of erythrocyte count and oxygenation state of haemoglobin. J Physiol 572, 295-305.
13. González-Alonso J, Olsen DB & Saltin B (2002). Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: Role of circulating ATP. Circ Res 91, 1046-1055.
14. González-Alonso J, Quistorff B, Krustrup P, Bangsbo J & Saltin B (2000). Heat production in human skeletal muscle at the onset of intense dynamic exercise. J Physiol 524, 603-615.
15. Guyton AC, Douglas BH, Langston JB & Richardson TQ (1962). Instantaneous increase in mean circulatory pressure and cardiac output at onset of muscular activity. Circ Res 11, 431-441.
16. Hamann JJ, Valic Z, Buckwalter JB & Clifford PS (2003). Muscle pump does not enhance blood flow in exercising skeletal muscle. J Appl Physiol 94, 6-10.
17. Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE & Cobb FR (1986). Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res 58, 281-291.
18. Ichinose M, Saito M, Kondo N & Nishiyasu T (2006). Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans. Am J Physiol Heart Circ Physiol 290, H1419-H1426.
19. Joyner MJ & Halliwill JR (2000). Sympathetic vasodilatation in human limbs. J Physiol 526, 471-480.
20. Keul J, Dickhuth HH, Simon G & Lehmann M (1981). Effect of static and dynamic exercise on heart volume, contractility, and left ventricular dimensions. Circ Res 48, I162-I1170.
21. Kindig AE, Hayes SG & Kaufman MP (2007). Purinergic 2 receptor blockade prevents the responses of group IV afferents to post-contraction circulatory occlusion. J Physiol 578, 301-308.
22. Kirby BS, Carlson RE, Markwald RR, Voyles WF & Dinenno F (2007). Mechanical influences on skeletal muscle tone in humans: Insight into contraction-induced rapid vasodilatation. J Physiol 583, 861-874.
23. Laughlin MH (1987). Skeletal muscle blood flow capacity: Role of muscle pump in excercise hyperemia. Am J Physiol 253, H993-1004.
24. Laughlin MH & Joyner M (2003). Closer to the edge? Contractions, pressures, waterfalls and blood flow to contracting skeletal muscle. J Appl Physiol 94, 3-15.
25. Laughlin MH, Korthuis RJ, Duncker DJ & Bache RJ (1996). Control of blood flow to cardiac and skeletal muscle during exercise. In Handbook of Physiology, section 12, Exercise: Regulation and Integration of Multiple Systems, chap. 16, pp. 705-769, ed. Rowell LB & Shepherd JT, American Physiological Society, Bethesda, MD, USA.
26. Laughlin MH & Schrage WG (1999). Effects of muscle contraction on skeletal muscle blood flow: When there is a muscle pump? Med Sci Sport Exerc 31, 1027-1035.
27. Magder S (2005). The classical Guyton view that mean systemic pressure, right atrial pressure, and venous resistance governs venous return is/is not correct. J Appl Physiol 101, 1533.
28. Magnusson G, Kaijser L, Isberg B & Saltin B (1994). Cardiovascular responses during one- and two-legged exercise in middle-aged men. Acta Physiol Scand 150, 353-362.
29. Mitchell JH, Reeves DR Jr, Rogers HB & Secher NH (1989). Epidural anaesthesia and cardiovascular responses to static exercise in man. J Physiol 417, 13-24.
30. Mortensen SP, Dawson EA, Yoshiga CC, Dalsgaard MK, Damsgaard R, Secher NH & González-Alonso J (2005). Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans. J Physiol 566, 273-285.
31. Notarius CF & Magder S (1996). Central venous pressure during exercise: Role of muscle pump. Can J Physiol Pharmacol 74, 647-651.
32. Poliner LR, Dehmer GJ, Lewis SE, Parkey RW, Blomqvist CG & Willerson JT (1980). Left ventricular performance in normal subjects: A comparison of the responses to exercise in the upright and supine positions. Circulation 62, 528-534.
33. Pollack AA & Wood EH (1949). Venous pressure in the saphenous vein at the ankle in man during exercise and changes in posture. J Appl Physiol 1, 649-662.
34. Rådegran G (1997). Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee-extensor exercise in humans. J Appl Physiol 83, 1383-1388.
35. Rådegran G & Calbet JA (2001). Role of adenosine in exercise-induced human skeletal muscle vasodilation. Acta Physiol Scand 171, 177-185.
36. Rådegran G & Hellsten Y (2000). Adenosine and nitric oxide in exercise-induced human skeletal muscle vasodilatation. Acta Physiol Scand 168, 575-591.
37. 2 transport. J Clin Invest 96, 1916-1926.
38. Rosenmeier JB, Hansen J & González-Alonso J (2004). Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol 558, 351-365.
39. Rothe CF (2005). The muscle pump indeed raises muscle blood flow during locomotion. J Appl Physiol 99, 773.
40. Rowell LB (1992). Reflex control of the circulation during exercise. Int J Sports Med 13 (Suppl. 1), S25-S27.
41. Rowell LB (1993). Central circulatory adjustments to dynamic exercise. In Human Cardiovascular Control. Oxford University Press, New York.
42. Rowell LB (2004). Ideas about control of skeletal and cardiac muscle blood flow (1876-2003): Cycles of revision and new vision. J Appl Physiol 97, 384-392.
43. Rowell LB, O'Leary DS & Kellong DL (1996). Integration of cardiovascular control systems in dynamic exercise. In Handbook of Physiology, section 12, Exercise: Regulation and Integration of Multiple Systems, pp. 771-781, ed. Rowell LB & Shepherd JT. American Physiological Society, Bethesda, MD, USA.
44. Rowell LB, Saltin B, Kiens B & Christensen NJ (1986). Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia? Am J Physiol Heart Circ Physiol 251, H1038-H1044.
45. Rowland TW (2005). Circulatory responses to exercise: Are we misreading Fick? Chest 127, 1023-1030.
46. Saltin B (2007). Exercise hyperaemia: Magnitude and aspects on regulation in humans. J Physiol 586, 123-130.
47. Savard GK, Nielsen B, Laszczynska J, Larsen BE & Saltin B (1988). Muscle blood flow is not reduced in humans during moderate exercise and heat stress. J Appl Physiol 64, 649-657.
48. Shepherd JT (1983). Circulation to skeletal muscle. In Handbook of Physiology, section 2, The Cardiovascular System, vol. III, Peripheral Circulation and Organ Blood Flow, pp. 319-370. ed. Shepherd JT & Abboud FM. American Physiological Society, Bethesda, MD, USA.
49. Sheriff D (2005). Point: The muscle pump raises muscle blood flow during locomotion. J Appl Physiol 99, 371-372; discussion 374-375.
50. Sheriff DD, Rowell LB & Scher AM (1993). Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump? Am J Physiol Heart Circ Physiol 265, H1227-H1234.
51. Shiotani I, Sato H, Yokoyama H, Ohnishi Y, Hishida E, Kinjo K, Nakatani D, Kuzuya T & Hori M (2002). Muscle pump-dependent self-perfusion mechanism in legs in normal subjects and patients with heart failure. J Appl Physiol 92, 1647-1654.
52. Stinson EB, Griepp RB, Schroeder JS, Dong E Jr & Shumway NE (1972). Hemodynamic observations one and two years after cardiac transplantation in man. Circulation 45, 1183-1194.
53. Tschakovsky ME, Rogers AM, Pyke KE, Saunders NR, Glenn N, Lee SJ, Weissgerber T & Dwyer EM (2004). Immediate exercise hyperemia in humans is contraction intensity dependent: Evidence for rapid vasodilatation. J Appl Physiol 96, 639-644.
54. Verani MS, Nishimura S, Mahmarian JJ, Hays JT & Young JB (1994). Cardiac function after orthotopic heart transplantation: Response to postural changes, exercise, and b-adrenergic blockade. J Heart Lung Transplant 13, 181-193.
55. Von Euler US. (1974). Sympatho-adrenal activity in physical exercise. Med Sci Sports 6, 165-173.
56. Wray DW, Donato AJ, Uberoi A, Merlone JP & Richardson RS (2005). Onset exercise hyperaemia in humans: Partitioning the contributors. J Physiol 565, 1053-1060.