Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects

Journal of Applied Physiology

Volumn 96, Issue 6, 2004, Pages 2333-2340

  Laitinen, Tomi ^a   Niskanen, Leo ^a   Geelen, Ghislaine ^b   Länsimies, Esko ^a   Hartikainen, Juha ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Autonomic nervous system; Baroreflex sensitivity; Blood pressure variability; Heart rate variability

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; AMPLITUDE MODULATION; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; BODY POSTURE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CORRELATION ANALYSIS; ELDERLY CARE; FEMALE; HEAD TILTING; HEART RATE; HEART STROKE VOLUME; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; MALE; NON INVASIVE MEASUREMENT; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SPECTROMETRY; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

ADULT; AGED; AGING; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; EXERCISE TEST; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; POSTURE; SEX CHARACTERISTICS; SUPINE POSITION; TILT-TABLE TEST;

EID: 2542452904     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00444.2003     Document Type: Article

References (61)

1. Akselrod S, Oz O, Greenberg M, and Keselbrener L. Autonomic response to change of posture among normal and mild-hypertensive adults: investigation by time-dependent spectral analysis. J Auton Nerv Syst 64: 33-43, 1997.
2. Appenzeller O. Aging, stress, and autonomic control. In: Clinical Neurology of Aging (2nd ed.), edited by Albert ML and Knoefel JE. New York: Oxford University Press, 1994, p. 651-673.
3. Barnett SR, Morin RJ, Kiely DK, Gagnon M, Azhar G, Knight EL, Nelson JC, and Lipsitz LA. Effects of age and gender on autonomic control of blood pressure dynamics. Hypertension 33: 1195-1200, 1999.
4. Byrne EA, Fleg JL, Vaitkevicius PV, Wright J, and Porges SW. Role of aerobic capacity and body mass index in the age-associated decline in heart rate variability. J Appl Physiol 81: 743-750, 1996.
5. Cloarec-Blanchard L, Func-Bretano C, Lipski M, and Macquin-Mavier I. Repeatability of spectral components of short-term blood pressure and heart rate variability during acute sympathetic activation in healthy young male subjects. Clin Sci 93: 21-28, 1997.
6. Colosimo A, Giuliani A, Mancini AM, Piccirillo G, and Marigliano V. Estimating a cardiac age by means of heart rate variability. Am J Physiol Heart Circ Physiol 273: H1841-H1847, 1997.
7. Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, and Vernikos-Danellis J. Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol 68: 1458-1464, 1990.
8. Cooke WH, Hoag JB, Crossman AA, Kuusela TA, Tahvanainen KU, and Eckberg DL. Human responses to upright tilt: a window on central autonomic integration. J Physiol 517: 617-628, 1999.
9. Cowen T. Ageing in the autonomic nervous system: a result of nerve-target interactions? A review. Mech Ageing Dev 68: 163-173, 1993.
10. Cowie MR and Rawles JM. A modified method of quantifying the carotid baroreflex-heart rate reflex in man: the effect of age and blood pressure. Clin Sci 77: 223-228, 1989.
11. Craft N and Schwartz JB. Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans. Am J Physiol Heart Circ Physiol 268: H1441-H1452, 1995.
12. DeBoer RW, Karemaker JM, and Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
13. Eckberg DL and Sleight P. Human Baroreflexes in Health and Disease. Oxford, UK: Clarendon, 1992.
14. Esler MD, Thompson JM, Kaye DM, Turner AG, L JG, Cox HS, Lambert GW, and Seals DR. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation 91: 351-358, 1995.
15. Caird FI, Andrews GR, and Kennedy RD. Effect of posture on blood pressure in the elderly. Br Heart J 35: 527-530, 1973.
16. Geelen G, Laitinen T, Hartikainen J, Lansimies E, Bergstrom K, and Niskanen L. Gender influence on vasoactive hormones at rest and during a 70° head-up tilt in healthy humans. J Appl Physiol 92: 1401-1408, 2002.
17. Harrison MH, Rittenhouse D, and Greenleaf JE. Effect of posture on arterial baroreflex control of heart rate in humans. Eur J Appl Physiol 55: 367-373, 1986.
18. Hayano J, Taylor JA, Yamada A, Mukai S, Hori R, Asakawa T, Yokoyama K, Watanabe Y, Takata K, and Fujinami T. Continuous assessment of hemodynamic control by complex demodulation of cardiovascular variability. Am J Physiol Heart Circ Physiol 264: H1229-H1238, 1993.
19. Hughson RL, Quintin L, Annat G, Yamamoto Y, and Gharib C. Spontaneous baroreflex by sequence and power spectral methods in humans. Clin Physiol 13: 663-676, 1993.
20. Iwase S, Mano T, Watanabe T, Saito M, and Kobayashi F. Age-related changes of sympathetic outflow to muscles in humans. J Gerontol 46: M1-M5, 1991.
21. Kardos A, Rudas L, Simon J, Gingl Z, and Csanády M. Effect of postural changes on arterial baroreflex sensitivity assessed by the spontaneous sequence method and Valsalva manoeuvre in healthy subjects. Clin Auton Res 7: 143-148, 1997.
22. Kingwell BA, Thompson JM, Kaye DM, McPherson GA, Jennings GL, and Esler MD. Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure. Circulation 90: 234-240, 1994.
23. Laitinen T, Hartikainen J, Vanninen E, Niskanen L, Geelen G, and Länsimies E. Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 84: 576-583, 1998.
24. Laitinen T, Niskanen L, Hartikainen J, Geelen G, and Länsimies E. Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects. Am J Physiol Heart Circ Physiol 276: H1245-H1252, 1999.
25. Linden D and Diehl RR. Estimation of baroreflex sensitivity using transfer function analysis: normal values and theoretical considerations. Clin Auton Res 6: 157-161, 1996.
26. Lipsitz LA. Orthostatic hypotension in the elderly. N Engl J Med 321: 952-957, 1989.
27. Lipsitz LA, Nyquist RPJ, Wei JY, and Rowe JW. Postprandial reduction in blood pressure in the elderly. N Engl J Med 309: 81-83, 1983.
28. Low PA. The effect of aging on the autonomic nervous system. In: Clinical Autonomic Disorders: Evaluation and Management, edited by Low PA. Boston, MA: Little, Brown, 1993, p. 685-700.
29. Mader SL. Aging and postural hypotension. An update. J Am Geriatr Soc 37: 129-137, 1989.
30. Mathias CJ. Orthostatic hypotension: causes, mechanisms, and influencing factors. Neurology 45, 4 Suppl 5: S6-11, 1995.
31. Monahan KD, Dinenno FA, Seals DR, Clevenger CM, Desouza CA, and Tanaka H. Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol 281: H284-H289, 2001.
32. Montano N, Ruscone TG, Porta A, Lombardi F, Pagani M, and Malliani A. Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 90: 1826-1831, 1994.
33. Mukai S and Hayano J. Heart rate and blood pressure variabilities during graded head-up tilt. J Appl Physiol 78: 212-216, 1995.
34. Nagle F, Balke B, Baptista G, Alleyia J, and Howley E. Compatibility of progressive treadmill, bicycle and step tests based on oxygen uptake responses. Med Sci Sports 3: 149-154, 1971.
35. Ng AV, Callister R, Johnson DG, and Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 21: 498-503, 1993.
36. Novak V, Spies JM, Novak P, McPhee BR, Rummans TA, and Low PA. Hypocapnia and cerebral hypoperfusion in orthostatic intolerance. Stroke 29: 1876-1881, 1998.
37. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, and Somers VK. Relationships between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 95: 1441-1448, 1997.
38. Parati G, Frattola A, Di Rienzo M, Castiglioni P, and Mancia G. Broadband spectral analysis of blood pressure and heart rate variability in very elderly subjects. Hypertension 30: 803-808, 1997.
39. Pfeifer MA, Weinberg CR, Cook D, Best JD, Reenan A, and Halter JB. Differential changes of autonomic nervous system function with age in man. Am J Med 75: 249-258, 1983.
40. Piccirillo G, Bucca C, Bauco C, Cinti AM, Michele D, Fimognari FL, Cacciafesta M, and Marigliano V. Power spectral analysis of heart rate in subjects over a hundred years old. Int J Cardiol 63: 53-61, 1998.
41. Pickering TG, Gribbin B, Petersen TG, Cunningham DJC, and Sleight P. Comparison of the effects of exercise and posture on the baroreflex in man. Cardiovasc Res 5: 582-586, 1971.
42. Pomeranz B, Macaulay RJB, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ, and Benson H. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol Heart Circ Physiol 248: H151-H153, 1985.
43. Pöyhönen M, Syväoja S, Hartikainen J, Ruokonen E, and Takala J. The effect of carbon dioxide, respiratory rate and tidal volume on human heart rate variability, Acta Anaesthesiol Scand 48: 93-101, 2004.
44. Randall O, Esler M, Culp B, Julius S, and Zweifler A. Determinants of baroreflex sensitivity in man. J Lab Clin Med 91: 514-519, 1978.
45. Robbe HWJ, Mulder LJM, Rüddel H, Langewitz WA, Veldman JBP, and Mulder G. Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension 10: 538-543, 1987.
46. Rudas L, Crossman AA, Morillo CA, Halliwill JR, Tahvanainen KUO, Kuusela TA, and Eckberg DL. Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine. Am J Physiol Heart Circ Physiol 276: H1691-H1698, 1999.
47. Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, and Tell GS. Orthostatic hypotension in older adults. The cardiovascular health study. Hypertension 19: 508-519, 1992.
48. Schwartz JB, Gibb WJ, and Tran T. Aging effects on heart rate variability. J Gerontol 46: M99-M106, 1991.
49. Serrador JM, Bondar RL, and Hughson RL. Ventilatory response to passive head up tilt. Adv Exp Med Biol 450: 133-139, 1998.
50. Shannon RP, Maher KA, Santinga JT, Royal HD, and Wei JY. Comparison of differences in the hemodynamic response to passive postural stress in healthy subjects greater than 70 years and less than 30 years of age. Am J Cardiol 67: 1110-1116, 1991.
51. Shimada K, Kitazumi T, Sadakane N, Ogura H, and Ozawa T. Age-related changes of baroreflex function, plasma norepinephrine, and blood pressure. Hypertension 7: 113-117, 1985.
52. CO2 inversely affects MSNA response to orthostatic stress. Am J Physiol Heart Circ Physiol 281: H1040-H1046, 2001.
53. Smith JJ, Hughes CV, Ptacin MJ, Barney JA, Tristani FE, and Ebert TJ. The effect of age on hemodynamic response to graded postural stress in normal men. J Gerontol 42: 406-411, 1987.
54. Smith JJ and Porth CJM. Age and the response to orthostatic stress. In: Circulatory Response to the Upright Posture. Boca Raton, FL: CRC, 1990, p. 121-139.
55. Sundblad P and Linnarsson D. Slowing of carotid-cardiac baroreflex with standing and with isometric and dynamic muscle activity. Am J Physiol Heart Circ Physiol 271: H1363-H1369, 1996.
56. Tahvanainen K, Länsimies E, Tikkanen P, Hartikainen J, Kärki T, Lyyra T, and Mäntysaari M. Microcomputer-based monitoring of cardiovascular functions in simulated microgravity. Adv Space Res 12: 227-236, 1992.
57. Triedman JK, Cohen RC, and Saul JP. Mild hypovolemic stress alters autonomic modulation of heart rate. Hypertension 21: 236-247, 1993.
58. Tsuji H, Venditti FJ, Manders ES, Evans JC, Larson MG, Feldman CL, and Levy D. Determinants of heart rate variability. J Am Coll Cardiol 28: 1539-1546, 1996.
59. Veerman DP, Imholz BPM, Wieling W, Karemaker JM, and van Montfrans GA. Effects of aging on blood pressure variability in resting conditions. Hypertension 24: 120-130, 1994.
60. Wesseling KH, Jansen JR, Settels JJ, and Schreuder JJ. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol 74: 2566-2573, 1993.
61. Yo Y, Nagano M, Nagano N, Iiyama K, Higaki J, Mikami H, and Ogihara T. Effects of age and hypertension on autonomic nervous regulation during passive head-up tilt. Hypertension 23, Suppl I: I-82-I-86, 1994.