Attenuated exercise induced hyperaemia with age: Mechanistic insight from passive limb movement

Journal of Physiology

Volumn 588, Issue 22, 2010, Pages 4507-4517

  McDaniel, John ^a,c   Hayman, Melissa A ^b   Ives, Steve ^b   Fjeldstad, Anette S ^c   Trinity, Joel D ^a,c   Wray, D Walter ^a,b,c   Richardson, Russell S ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ARTICLE; EXERCISE; FEMORAL ARTERY FLOW; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; LIMB MOVEMENT; MALE; MEAN ARTERIAL PRESSURE; METABOLISM; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AGING; BLOOD FLOW VELOCITY; EXERCISE; EXTREMITIES; HUMANS; HYPEREMIA; LEG; MALE; MOTION THERAPY, CONTINUOUS PASSIVE; MOVEMENT; YOUNG ADULT;

EID: 78449248064     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.198770     Document Type: Article

References (58)

1. Adreani CM, Hill JM & Kaufman MP (1997). Responses of group III and IV muscle afferents to dynamic exercise. J Appl Physiol 82, 1811-1817.
2. Adreani CM & Kaufman MP (1998). Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol 84, 1827-1833.
3. Armstrong RB, Vandenakker CB & Laughlin MH (1985). Muscle blood flow patterns during exercise in partially curarized rats. J Appl Physiol 58, 698-701.
4. Baum K, Selle K, Leyk D & Essfeld D (1995). Comparison of blood pressure and heart rate responses to isometric exercise and passive muscle stretch in humans. Eur J Appl Physiol Occup Physiol 70, 240-245.
5. Beere PA, Russell SD, Morey MC, Kitzman DW & Higginbotham MB (1999). Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. Circulation 100, 1085-1094.
6. Bogert LW & Van Lieshout JJ (2005). Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 90, 437-446.
7. Carlson RE, Kirby BS, Voyles WF & Dinenno FA (2008). Evidence for impaired skeletal muscle contraction-induced rapid vasodilation in aging humans. Am J Physiol Heart Circ Physiol 294, H1963-1970.
8. Clifford PS, Kluess HA, Hamann JJ, Buckwalter JB & Jasperse JL (2006). Mechanical compression elicits vasodilatation in rat skeletal muscle feed arteries. J Physiol 572, 561-567.
9. Coote JH, Hilton SM & Perez-Gonzalez JF (1971). The reflex nature of the pressor response to muscular exercise. J Physiol 215, 789-804.
10. De Wilde RB, Geerts BF, Cui J, Van Den Berg PC & Jansen JR (2009). Performance of three minimally invasive cardiac output monitoring systems. Anaesthesia 64, 762-769.
11. Dinenno FA, Jones PP, Seals DR & Tanaka H (1999). Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation 100, 164-170.
12. Dinenno FA, Tanaka H, Stauffer BL & Seals DR (2001). Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented α-adrenergic vasoconstriction. J Physiol 536, 977-983.
13. Donato AJ, Uberoi A, Wray DW, Nishiyama S, Lawrenson L & Richardson RS (2006). Differential effects of aging on limb blood flow in humans. Am J Physiol Heart Circ Physiol 290, H272-278.
14. Ebert TJ, Morgan BJ, Barney JA, Denahan T & Smith JJ (1992). Effects of aging on baroreflex regulation of sympathetic activity in humans. Am J Physiol Heart Circ Physiol 263, H798-803.
15. Eldridge FL, Millhorn DE, Kiley JP & Waldrop TG (1985). Stimulation by central command of locomotion, respiration and circulation during exercise. Respir Physiol 59, 313-337.
16. Fagraeus L & Linnarsson D (1976). Autonomic origin of heart rate fluctuations at the onset of muscular exercise. J Appl Physiol 40, 679-682.
17. Fisher JP, Kim A, Young CN, Ogoh S, Raven PB, Secher NH & Fadel PJ (2009). Influence of ageing on carotid baroreflex peak response latency in humans. J Physiol 587, 5427-5439.
18. Glenn GM, Laughlin MH & Armstrong RB (1987). Muscle blood flow and fiber activity in partially curarized rats during exercise. J Appl Physiol 63, 1450-1456.
19. Gonzalez-Alonso J, Mortensen SP, Jeppesen TD, Ali L, Barker H, Damsgaard R, Secher NH, Dawson EA & Dufour SP (2008). Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function. J Physiol 586, 2405-2417.
20. Hammer LW & Boegehold MA (2005). Functional hyperaemia is reduced in skeletal muscle of aged rats. Microcirculation 12, 517-526.
21. Hellsten Y, Rufener N, Nielsen JJ, Hoier B, Krustrup P & Bangsbo J (2008). Passive leg movement enhances interstitial VEGF protein, endothelial cell proliferation, and eNOS mRNA content in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 294, R975-982.
22. Herr MD, Imadojemu V, Kunselman AR & Sinoway LI (1999). Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol 86, 767-772.
23. Jackson DN, Moore AW & Segal SS (2010). Blunting of rapid onset vasodilatation and blood flow in arterioles of exercising skeletal muscle with ageing in male mice. J Physiol 588, 2269-2282.
24. Jones PR & Pearson J (1969). Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J Physiol 204, 63P-66P.
25. Kirby BS, Carlson RE, Markwald RR, Voyles WF & Dinenno FA (2007). Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatation. J Physiol 583, 861-874.
26. Kirby BS, Voyles WF, Simpson CB, Carlson RE, Schrage WG & Dinenno FA (2009). Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration. J Physiol 587, 1989-2003.
27. Kooijman M, Thijssen DH, De Groot PC, Bleeker MW, Van Kuppevelt HJ, Green DJ, Rongen GA, Smits P & Hopman MT (2008). Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans. J Physiol 586, 1137-1145.
28. Laitinen T, Hartikainen J, Vanninen E, Niskanen L, Geelen G & Lansimies E (1998). Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 84, 576-583.
29. Laughlin MH (1987). Skeletal muscle blood flow capacity: role of muscle pump in exercise hyperaemia. Am J Physiol Heart Circ Physiol 253, H993-1004.
30. Laughlin MH & Armstrong RB (1983). Rat muscle blood flows as a function of time during prolonged slow treadmill exercise. Am J Physiol Heart Circ Physiol 244, H814-824.
31. Lawrenson L, Poole JG, Kim J, Brown C, Patel P & Richardson RS (2003). Vascular and metabolic response to isolated small muscle mass exercise: effect of age. Am J Physiol Heart Circ Physiol 285, H1023-1031.
32. McDaniel J, Fjeldstad AS, Ives S, Hayman M, Kithas P & Richardson RS (2010). Central and peripheral contributors to skeletal muscle hyperaemia: response to passive limb movement. J Appl Physiol 108, 76-84.
33. McMahon SE & McWilliam PN (1992). Changes in R-R interval at the start of muscle contraction in the decerebrate cat. J Physiol 447, 549-562.
34. Monahan KD (2007). Effect of aging on baroreflex function in humans. Am J Physiol Regul Integr Comp Physiol 293, R3-R12.
35. Nobrega AC & Araujo CG (1993). Heart rate transient at the onset of active and passive dynamic exercise. Med Sci Sports Exerc 25, 37-41.
36. Nurhayati Y & Boutcher SH (1998). Cardiovascular response to passive cycle exercise. Med Sci Sports Exerc 30, 234-238.
37. Parker BA, Smithmyer SL, Pelberg JA, Mishkin AD, Herr MD & Proctor DN (2007). Sex differences in leg vasodilation during graded knee extensor exercise in young adults. J Appl Physiol 103, 1583-1591.
38. Pohl U, Holtz J, Busse R & Bassenge E (1986). Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8, 37-44.
39. Poole JG, Lawrenson L, Kim J, Brown C & Richardson RS (2003). Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am J Physiol Heart Circ Physiol 284, H1251-1259.
40. Proctor DN, Koch DW, Newcomer SC, Le KU & Leuenberger UA (2003a). Impaired leg vasodilation during dynamic exercise in healthy older women. J Appl Physiol 95, 1963-1970.
41. Proctor DN, Newcomer SC, Koch DW, Le KU, MacLean DA & Leuenberger UA (2003b). Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men. J Appl Physiol 94, 1859-1869.
42. Proctor DN, Shen PH, Dietz NM, Eickhoff TJ, Lawler LA, Ebersold EJ, Loeffler DL & Joyner MJ (1998). Reduced leg blood flow during dynamic exercise in older endurance-trained men. J Appl Physiol 85, 68-75.
43. Robinson BF, Epstein SE, Beiser GD & Braunwald E (1966). Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res 19, 400-411.
44. Rowell LB (1986). Human Circulation: Regulation During Physical Stress. Oxford University Press, New York.
45. Segal SS (2000). Integration of blood flow control to skeletal muscle: key role of feed arteries. Acta Physiol Scand 168, 511-518.
46. Sheriff DD, Rowell LB & Scher AM (1993). Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump? Am J Physiol Heart Circ Physiol 265, H1227-1234.
47. Stebbins CL, Brown B, Levin D & Longhurst JC (1988). Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J Appl Physiol 65, 1539-1547.
48. Sugawara J, Tanabe T, Miyachi M, Yamamoto K, Takahashi K, Iemitsu M, Otsuki T, Homma S, Maeda S, Ajisaka R & Matsuda M (2003). Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method. Acta Physiol Scand 179, 361-366.
49. Ter Woerds W, De Groot PC, Van Kuppevelt DH & Hopman MT (2006). Passive leg movements and passive cycling do not alter arterial leg blood flow in subjects with spinal cord injury. Phys Ther 86, 636-645.
50. Tschakovsky ME, Rogers AM, Pyke KE, Saunders NR, Glenn N, Lee SJ, Weissgerber T & Dwyer EM (2004). Immediate exercise hyperaemia in humans is contraction intensity dependent: evidence for rapid vasodilation. J Appl Physiol 96, 639-644.
51. Vianna LC, Ricardo DR & Araujo CG (2008). Training-related changes in the R-R interval at the onset of passive movements in humans. Braz J Med Biol Res 41, 825-832.
52. Warner HR & Cox A (1962). A mathematical model of heart rate control by sympathetic and vagus efferent information. J Appl Physiol 17, 349-355.
53. Williamson JW, Fadel PJ & Mitchell JH (2006). New insights into central cardiovascular control during exercise in humans: a central command update. Exp Physiol 91, 51-58.
54. Wray DW, Donato AJ, Uberoi A, Merlone JP & Richardson RS (2005). Onset exercise hyperaemia in humans: partitioning the contributors. J Physiol 565, 1053-1060.
55. Wray DW, Fadel PJ, Keller DM, Ogoh S, Sander M, Raven PB & Smith ML (2004). Dynamic carotid baroreflex control of the peripheral circulation during exercise in humans. J Physiol 559, 675-684.
56. Wray DW, Nishiyama SK, Monnet A, Wary C, Duteil S, Carlier PG & Richardson RS (2009a). Multiparametric NMR-based assessment of skeletal muscle perfusion and metabolism during exercise in elderly persons: preliminary findings. J Gerontol 64, 968-974.
57. Wray DW, Nishiyama SK, Monnet A, Wary C, Duteil SS, Carlier PG & Richardson RS (2009b). Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics. Am J Physiol Heart Circ Physiol 297, H1870-1875.
58. Wray DW & Richardson RS (2006). Aging, exercise, and limb vascular heterogeneity in humans. Med Sci Sports Exerc 38, 1804-1810.