Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity

Mucosal Immunology

Volumn 6, Issue 1, 2013, Pages 114-121

  Berin, M C ^a   Wang, W ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; TOLL LIKE RECEPTOR 9;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; GASTROINTESTINAL MUCOSA; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; IMMUNOREACTIVITY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PEANUT; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; TH2 CELL; WILD TYPE;

EID: 84874093231     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.55     Document Type: Article

References (39)

1. Ganeshan, K., Neilsen, C. V., Hadsaitong, A., Schleimer, R. P., Luo, X. & Bryce, P. J. Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J. Allergy Clin. Immunol. 123, 231-238 (2009) e4.
2. Snider, D. P., Marshall, J. S., Perdue, M. H. & Liang, H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153, 647-657 (1994). (Pubitemid 24206293)
3. Eisenbarth, S. C., Piggott, D. A., Huleatt, J. W., Visintin, I., Herrick, C. A. & Bottomly, K. Lipopolysaccharide-enhanced, toll-like receptor 4- dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645-1651 (2002). (Pubitemid 36026476)
4. Frick, O. L., Teuber, S. S., Buchanan, B. B., Morigasaki, S. & Umetsu, D. T. Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy 60, 243-250 (2005). (Pubitemid 40187481)
5. Li, X. M., Srivastava, K., Huleatt, J. W., Bottomly, K., Burks, A. W. & Sampson, H. A. Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. J. Immunol. 170, 3289-3295 (2003). (Pubitemid 36302207)
6. Li, X. M. et al. Persistent protective effect of heat-killed Escherichia coli producing " engineered, " recombinant peanut proteins in a murine model of peanut allergy. J. Allergy Clin. Immunol. 112, 159-167 (2003).
7. Bashir, M. E., Louie, S., Shi, H. N. & Nagler-Anderson, C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 172, 6978-6987 (2004). (Pubitemid 38669138)
8. Adel-Patient, K., Ah-Leung, S., Bernard, H., Durieux-Alexandrenne, C., Creminon, C. & Wal, J. M. Oral sensitization to peanut is highly enhanced by application of peanut extracts to intact skin, but is prevented when CpG and cholera toxin are added. Int. Arch. Allergy Immunol. 143, 10-20 (2007). (Pubitemid 46625232)
9. Senti, G. et al. Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin. Exp. Allergy. 39, 562-570 (2009).
10. McCluskie, M. J. & Davis, H. L. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine 19, 413-422 (2000).
11. Demento, S. L. et al. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J. Immunol. 185, 2989-2997 (2010).
12. Hall, J. A. et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29, 637-649 (2008).
13. Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell. Biol. 8, 1327-1336 (2006). (Pubitemid 44835107)
14. Lacroix-Lamande, S., Rochereau, N., Mancassola, R., Barrier, M., Clauzon, A. & Laurent, F. Neonate intestinal immune response to CpG oligodeoxynucleotide stimulation. PLoS One 4, e8291 (2009).
15. Hong, X. et al. Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood. J. Allergy Clin. Immunol. 128, 374-381 (2011) e2.
16. Sun, J. et al. Impact of CD40 ligand, B cells, and mast cells in peanutinduced anaphylactic responses. J. Immunol. 179, 6696-6703 (2007).
17. Arias, K. et al. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J. Allergy Clin. Immunol. 127, 1552-1561 (2011) e1.
18. Chambers, S. J., Wickham, M. S., Regoli, M., Bertelli, E., Gunning, P. A. & Nicoletti, C. Rapid in vivo transport of proteins from digested allergen across pre-sensitized gut. Biochem. Biophys. Res. Commun. 325, 1258-1263 (2004). (Pubitemid 39535898)
19. Roth-Walter, F. et al. Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches. Allergy. 63, 882-890 (2008). (Pubitemid 351832791)
20. Dunkin, D., Berin, M. C. & Mayer, L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. J. Allergy Clin. Immunol. 128, 1251-1258 (2011).
21. Liu, N., Ohnishi, N., Ni, L., Akira, S. & Bacon, K. B. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4, 687-693 (2003). (Pubitemid 36874446)
22. Ozcan, E., Rauter, I., Garibyan, L., Dillon, S. R. & Geha, R. S. Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J. Allergy Clin. Immunol. 128, 601-609 (2011) e1-4.
23. Duan, W. et al. Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. J. Allergy Clin. Immunol. 126, 1284-1293 (2010).
24. Genuneit, J. et al. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. Clin. Exp. Allergy. 39, 1875-1888 (2009).
25. Novak, N. et al. Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy 62, 766-772 (2007). (Pubitemid 46934363)
26. Ewaschuk, J. B., Backer, J. L., Churchill, T. A., Obermeier, F., Krause, D. O. & Madsen, K. L. Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA. Infect. Immun. 75, 2572-2579 (2007). (Pubitemid 46744349)
27. Lin, L., Gerth, A. J. & Peng, S. L. CpG DNA redirects class-switching towards " Th1-like " Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 34, 1483-1487 (2004). (Pubitemid 39256028)
28. Spiegelberg, H. L., Tighe, H., Roman, M., Broide, D. & Raz, E. Inhibition of IgE formation and allergic inflammation by allergen gene immunization and by CpG motif immunostimulatory oligodeoxynucleotides. Allergy 53 (45 Suppl), 93-97 (1998). (Pubitemid 28446507)
29. Ramaprakash, H., Ito, T., Standiford, T. J., Kunkel, S. L. & Hogaboam, C. M. Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice. Infect. Immun. 77, 108-119 (2009).
30. Hill, D. A. et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat. Med. 18, 538-546 (2012).
31. Milner, J. D. et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452, 773-776 (2008). (Pubitemid 351521078)
32. Varona, R. et al. CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J. Clin. Invest. 107, R37 - R45 (2001). (Pubitemid 32225363)
33. Luther, S. A., Ansel, K. M. & Cyster, J. G. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J. Exp. Med. 197, 1191-1198 (2003). (Pubitemid 36570074)
34. Auci, D. L., Chice, S. M., Heusser, C., Athanassiades, T. J. & Durkin, H. G. Origin and fate of IgE-bearing lymphocytes. II. Gut-associated lymphoid tissue as sites of first appearance of IgE-bearing B lymphocytes and hapten-specific IgE antibody-forming cells in mice immunized with benzylpenicilloyl-keyhole limpet hemocyanin by various routes: relation to asialo GM1 ganglioside+ cells and IgE/CD23 immune complexes. J. Immunol. 149, 2241-2248 (1992).
35. Bouskra, D. et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456, 507-510 (2008). (Pubitemid 352759006)
36. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000). (Pubitemid 32015992)
37. Berin, M. C., Zheng, Y., Domaradzki, M., Li, X. M. & Sampson, H. A. Role of TLR4 in allergic sensitization to food proteins in mice. Allergy 61, 64-71 (2006). (Pubitemid 43381193)
38. Lefrancois, L. & Lycke, N. Isolation of Mouse Small Intestinal Intraepithelial Lymphocytes, Peyer's Patch, and Lamina Propria Cells, Current Protocols of Immunology: Wiley & Sons, 1996.
39. Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511-2514 (1999). (Pubitemid 30026340)