Isolation and characterization of calcium sensing receptor null cells: A highly malignant and drug resistant phenotype of colon cancer

International Journal of Cancer

Volumn 132, Issue 9, 2013, Pages 1996-2005

  Singh, Navneet ^a   Liu, Guangming ^a   Chakrabarty, Subhas ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CaSR null; molecular profile

Indexed keywords

BETA CATENIN; CALCIUM SENSING RECEPTOR; CD133 ANTIGEN; FIBRONECTIN; FLUOROURACIL; HERMES ANTIGEN; MICRORNA; MICRORNA 135A; MICRORNA 135B; MICRORNA 145; MICRORNA 21; NERVE CELL ADHESION MOLECULE; SURVIVIN; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL 1; TRANSCRIPTION FACTOR SNAIL 2; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL INVASION; CELL ISOLATION; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MONOLAYER CULTURE; NULL CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPHEROID CELL; UPREGULATION; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; FLUOROURACIL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; MICRORNAS; NEOPLASM INVASIVENESS; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CALCIUM-SENSING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84874057984     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27902     Document Type: Article

References (50)

1. Brown EM, Gamba G, Riccardi D, et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-80.
2. Brown EM, MacLeod RJ,. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001; 81: 239-97.
3. Hofer AM, Brown EM,. Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 2003; 4: 530-8.
4. Ruat M, Molliver ME, Snowman AM, et al. Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci USA 1995; 92: 3161-5.
5. Wang R, Xu C, Zhao W, et al. Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues. Eur J Biochem 2003; 270: 2680-8.
6. Gama L, Baxendale-Cox LM, Breitwieser GE,. Ca2+-sensing receptors in intestinal epithelium. Am J Physiol 1997; 273: C1168-C1175.
7. Cheng I, Klingensmith ME, Chattopadhyay N, et al. Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab 1998; 83: 703-7.
8. Rutten MJ, Bacon KD, Marlink KL, et al. Identification of a functional Ca2+-sensing receptor in normal human gastric mucous epithelial cells. Am J Physiol 1999; 277: G662-G670.
9. McNeil L, Hobson S, Nipper V, et al. Functional calcium-sensing receptor expression in ovarian surface epithelial cells. Am J Obstet Gynecol 1998; 178: 305-13.
10. Ray JM, Squires PE, Curtis SB, et al. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 1997; 99: 2328-33.
11. Chang W, Tu C, Chen TH, et al. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 1999; 140: 5883-93.
12. Chakrabarty S, Radjendirane V, Appelman H, et al. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003; 63: 67-71.
13. Chakrabarty S, Wang H, Canaff L, et al. Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3). Cancer Res 2005; 65: 493-8.
14. Bhagavathula N, Kelley EA, Reddy M, et al. Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. Br J Cancer 2005; 93: 1364-71.
15. Bhagavathula N, Hanosh AW, Nerusu KC, et al. Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. Int J Cancer 2007; 121: 1455-62.
16. Liu G, Hu X, Varani J, et al. Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil. Mol Carcinog 2009; 48: 202-11.
17. Liu G, Hu X, Chakrabarty S,. Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. Int J Cancer 2010; 126: 631-9.
18. Hizaki K, Yamamoto H, Taniguchi H, et al. Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. Mod Pathol 2011; 24: 876-84.
19. Liu G, Hu X, Premkumar L, et al. Nifedipine synergizes with calcium in activating the calcium sensing receptor, suppressing the expression of thymidylate synthase and survivin and promoting sensitivity to fluorouracil in human colon carcinoma cells. Mol Carcinog 2011; 50: 922-30.
20. Rey O, Chang W, Bikle D, et al. Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. J Biol Chem 2012; 287: 1158-67.
21. Pestalozzi BC, McGinn CJ, Kinsella TJ, et al. Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. Br J Cancer 1995; 71: 1151-7.
22. Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350: 2343-51.
23. Horikoshi T, Danenberg KD, Stadlbauer TH, et al. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 1992; 52: 108-16.
24. Kamoshida S, Matsuoka H, Ishikawa T, et al. Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy. Jpn J Clin Oncol 2004; 34: 594-601.
25. Popat S, Matakidou A, Houlston RS,. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2004; 22: 529-36.
26. Altieri DC,. Survivin in apoptosis control and cell cycle regulation in cancer. Prog Cell Cycle Res 2003; 5: 447-52.
27. Johnson ME, Howerth EW,. Survivin: a bifunctional inhibitor of apoptosis protein. Vet Pathol 2004; 41: 599-607.
28. Fukuda S, Pelus LM,. Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther 2006; 5: 1087-98.
29. Brattain MG, Levine AE, Chakrabarty S, et al. Heterogeneity of human colon carcinoma. Cancer Metastasis Rev 1984; 3: 177-91.
30. Nagel R, le Sage C, Diosdado B, et al. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 2008; 68: 5795-802.
31. Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15.
32. O'Brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-10.
33. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007; 445: 111-15.
34. Marhaba R, Klingbeil P, Nuebel T, et al. CD44 and EpCAM: cancer-initiating cell markers. Curr Mol Med 2008; 8: 784-804.
35. Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113: 643-55.
36. Takayama T, Miyanishi K, Hayashi T, et al. Colorectal cancer: genetics of development and metastasis. J Gastroenterol 2006; 41: 185-92.
37. Takeichi M,. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451-5.
38. Kalluri R, Neilson EG,. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-84.
39. Thiery JP,. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
40. Lee JM, Dedhar S, Kalluri R, et al. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 973-81.
41. Zeisberg M, Neilson EG,. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-37.
42. Bandres E, Cubedo E, Agirre X, et al. Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer 2006; 5: 29.
43. Michael MZ, SM OC, van Holst Pellekaan NG, et al. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 2003; 1: 882-91.
44. Shi B, Sepp-Lorenzino L, Prisco M, et al. Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem 2007; 282: 32582-90.
45. Chikatsu N, Fukumoto S, Takeuchi Y, et al. Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas. J Biol Chem 2000; 275: 7553-7.
46. Canaff L, Hendy GN,. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002; 277: 30337-50.
47. Laaksonen M, Karkkainen M, Outila T, et al. Vitamin D receptor gene BsmI-polymorphism in Finnish premenopausal and postmenopausal women: its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors. J Bone Miner Metab 2002; 20: 383-90.
48. Aslam MN, Paruchuri T, Bhagavathula N, et al. A mineral-rich red algae extract inhibits polyp formation and inflammation in the gastrointestinal tract of mice on a high-fat diet. Integr Cancer Ther 2010; 9: 93-9.
49. Clevers H,. Stem cells, asymmetric division and cancer. Nat Genet 2005; 37: 1027-8.
50. Morrison SJ, Kimble J,. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006; 441: 1068-74.