Cepharanthine Suppresses Metastatic Potential of Human Cholangiocarcinoma Cell Lines

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue SUPPL.1, 2012, Pages 149-154

  Uthaisar, Kwuntida ^a,b,c   Seubwai, Wunchana ^a,b   Srikoon, Pattravedee ^c   Vaeteewoottacharn, Kulthida ^a,b   Sawanyawisuth, Kanlayanee ^a,b   Okada, Seiji ^c   Wongkham, Sopit ^a,b  

^a KHON KAEN UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Bile duct cancer; Invasion; Metastasis; Migration; NF kB

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1;

ANIMAL; APOPTOSIS; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CELL PROLIFERATION; DRUG EFFECTS; HUMAN; INTRAHEPATIC BILE DUCT; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; HUMANS; INTERCELLULAR ADHESION MOLECULE-1;

EID: 84874055167     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.KKSuppl.149     Document Type: Article

References (39)

1. Abe T, Koike K, Ohga T, et al (1995). Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapam il in human glioma cell lines overexpressing MRP or MDR1. Br J Cancer, 72, 418-23.
2. Bernhard EJ, Gruber SB, Muschel RJ (1994). Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA, 91, 4293-7.
3. Biswas KK, Tancharoen S, Sarker KP, et al (2006). Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. FEBS Lett, 580, 703-10.
4. Ebina T, Ishikawa K, Murata K (1990). [Antitumor effect of Cepharanthin in the double grafted tumor system]. Gan To Kagaku Ryoho, 17, 1165-71.
5. Furusawa S, Wu J (2007). The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases. Life Sci, 80, 1073-9.
6. Furusawa S, Wu J, Fujimura T, et al (1998). Cepharanthine inhibits proliferation of cancer cells by inducing apoptosis. Methods Find Exp Clin Pharmacol, 20, 87-97.
7. Harada K, Bando T, Yoshida H, Sato M (2001). Characteristics of antitumour activity of cepharanthin against a human adenosquamous cell carcinoma cell line. Oral Oncol, 37, 643-51.
8. Harada K, Ferdous T, Itashiki Y, et al (2009). Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Int J Oncol, 35, 1025-35.
9. Hashizume T, Yamaguchi H, Sato T, Fujii T (1991). Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets. Biochem Pharmacol, 41, 419-23.
10. Hemers E, Duval C, McCaig C, et al (2005). Insulinlike growth factor binding protein-5 is a target of matrix metalloproteinase-7: implications for epithelial-mesenchymal signaling. Cancer Res, 65, 7363-9.
11. Hibasami H, Takaji S, Murata T, Nakashima K (1991). Cepharanthine potentiates the antitumor effect of methylglyoxal bis (cyclopentylamidinohydrazone) on human leukemia cells. Anticancer Res, 11, 1543-7.
12. Ito H, Ito H, Amano H, Noda H (1991). Inhibitory effect of a biscoclaurine alkaloid, cepharanthin, on lung metastasis of Lewis lung carcinoma. Jpn J Pharmacol, 56, 195-202.
13. Kato T, Suzumura Y (1987). Potentiation of antitumor activity of vincristine by the biscoclaurine alkaloid cepharanthine. J Natl Cancer Inst, 79, 527-32.
14. Kaufmann SH, Earnshaw WC (2000). Induction of apoptosis by cancer chemotherapy. Exp Cell Res, 256, 42-9.
15. Kleiner DE, Stetler-Stevenson WG (1999). Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol, 43, 42-51.
16. Kohno H, Inoue H, Seyama Y, et al (1987). [Mode of the antiallergic action of cepharanthine on an experimental model of allergic rhinitis]. Nihon Yakurigaku Zasshi, 90, 205-11.
17. Kohno H, Seyama Y, Yamashita S, et al (1986). [Effects of cepharanthine on experimental nasal allergy]. Nihon Yakurigaku Zasshi, 88, 71-6.
18. Kometani M, Kanaho Y, Sato T, Fujii T (1985). Inhibitory effect of cepharanthine on collagen-induced activation in rabbit platelets. Eur J Pharmacol, 111, 97-105.
19. Li X, Fujikura Y, Wang YH, et al (1997). Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats. J Oral Pathol Med, 26, 371-6.
20. Lin YC, Shun CT, Wu MS, Chen CC (2006). A novel anticancer effect of thalidomide: inhibition of intercellular adhesion molecule-1-mediated cell invasion and metastasis through suppression of nuclear factor-kappaB. Clin Cancer Res, 12, 7165-73.
21. McQuibban GA, Butler GS, Gong JH, et al (2001). Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem, 276, 43503-8.
22. McQuibban GA, Gong JH, Wong JP, et al (2002). Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood, 100, 1160-7.
23. Nakajima A, Yamamoto Y, Taura K, et al (2004). Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. Int J Oncol, 24, 635-45.
24. Okada K, Sakusabe N, Kobayashi A, et al (1999). Prevention of lung metastasis by intra-tumoral injection of Cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma. Jpn J Cancer Res, 90, 928-33.
25. Okamoto M, Okamoto T, Baba M (1999). Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. Antimicrob Agents Chemother, 43, 492-7.
26. Okamoto M, Ono M, Baba M (1998). Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. AIDS Res Hum Retroviruses, 14, 1239-45.
27. Overall CM, Kleifeld O (2006). Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer, 6, 227-39.
28. Konstantinopoulos PA, Karamouzis MV, Papatsoris AG, Papavassiliou AG (2008). Matrix metalloproteinase inhibitors as anticancer agents. Int J Biochem Cell Biol, 40, 1156-68.
29. Sawada T, Kimura K, Nishihara T, et al (2006). TGF-beta1 downregulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer. Adv Med Sci, 51, 60-5.
30. Seubwai W, Vaeteewoottacharn K, Hiyoshi M, et al (2010). Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB. Cancer Sci, 101, 1590-5.
31. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201.
32. Stetler-Stevenson WG (1994). Progelatinase A activation during tumor cell invasion. Invasion Metastasis, 14, 259-68.
33. Sun JJ, Zhou XD, Liu YK, et al (1999). Invasion and metastasis of liver cancer: expression of intercellular adhesion molecule 1. J Cancer Res Clin Oncol, 125, 28-34.
34. Takahashi-Makise N, Suzu S, Hiyoshi M, et al (2009). Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway. Int J Cancer, 125, 1464-72.
35. Tamatani T, Azuma M, Motegi K, et al (2007). Cepharanthinenhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells. Int J Oncol, 31, 761-8.
36. Tamez PA, Lantvit D, Lim E, Pezzuto JM (2005). Chemosensitizing action of cepharanthine against drugresistant human malaria, Plasmodium falciparum. J Ethnopharmacol, 98, 137-42.
37. Tsunezuka Y, Kinoh H, Takino T, et al (1996). Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay. Cancer Res, 56, 5678-83.
38. Wu J, Suzuki H, Zhou YW, et al (2001). Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines. J Cell Biochem, 82, 200-14.
39. Yasukawa K, Takido M, Takeuchi M, et al (1991). Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a] anthracene. J Cancer Res Clin Oncol, 117, 421-4.