Engineering the binding site of an antibody against N-glycolyl GM3: From functional mapping to novel anti-ganglioside specificities

ACS Chemical Biology

Volumn 8, Issue 2, 2013, Pages 376-386

  Rojas, Gertrudis ^a   Pupo, Amaury ^a   Gómez, Silvia ^a   Krengel, Ute ^b   Moreno, Ernesto ^a  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; AROMATIC COMPOUND; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GM3; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14F7; N ACETYL GM3; N GLYCOLOYLHEMATOSIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TUMOR ANTIGEN; UNCLASSIFIED DRUG; N-GLYCOLYLNEURAMINYLLACTOSYLCERAMIDE;

AMINO ACID SUBSTITUTION; ANTIBODY COMBINING SITE; ANTIBODY ENGINEERING; ANTIBODY SCREENING; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL DEATH; CONTROLLED STUDY; CROSS REACTION; CRYSTAL STRUCTURE; DRUG STRUCTURE; HEAVY CHAIN; HUMAN; IN VITRO STUDY; MOLECULAR EVOLUTION; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; ANALOGS AND DERIVATIVES; ANTIGEN ANTIBODY REACTION; CHEMICAL STRUCTURE; CHEMISTRY; GENE LIBRARY; GENETICS; IMMUNOLOGY; PROTEIN ENGINEERING;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; G(M3) GANGLIOSIDE; GENE LIBRARY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING;

EID: 84874039613     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3003754     Document Type: Article

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