Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody

Molecular Immunology

Volumn 48, Issue 8, 2011, Pages 1059-1067

  Fernández Marrero, Yuniel ^a   Hernández, Tays ^a   Roque Navarro, Lourdes ^a   Talavera, Ariel ^a   Moreno, Ernesto ^a   Griñán, Tania ^a   Vázquez, Ana María ^a   de Acosta, Cristina Mateo ^a   Pérez, Rolando ^a   López Requena, Alejandro ^a  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

Author keywords

Cytotoxic antibody; Ganglioside; GM3(Neu5Gc)

Indexed keywords

ARGININE; ASPARTIC ACID; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GM3; GLUTAMIC ACID; SERINE; SIALYLTRANSFERASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CYTOTOXICITY; GENE MUTATION; HEAVY CHAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CELL SURVIVAL; COMPLEMENTARITY DETERMINING REGIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; G(M2) GANGLIOSIDE; G(M3) GANGLIOSIDE; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING;

MAMMALIA;

EID: 79952454125     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.01.008     Document Type: Article

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