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Volumn 8, Issue 2, 2013, Pages

Folate Catabolites in Spot Urine as Non-Invasive Biomarkers of Folate Status during Habitual Intake and Folic Acid Supplementation

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FOLIC ACID; FOLIC ACID CATABOLITE; FOLIC ACID DERIVATIVE; GLUTAMIC ACID DERIVATIVE; PARA ACETAMIDOBENZOYLGLUTAMATE; PARA AMINOBENZOYLGLUTAMATE; UNCLASSIFIED DRUG;

EID: 84874010104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056194     Document Type: Article
Times cited : (12)

References (56)
  • 1
    • 48249134365 scopus 로고    scopus 로고
    • Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    • discussion S112-105
    • Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL (2008) Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 29: S101-111; discussion S112-105.
    • (2008) Food Nutr Bull , vol.29 , pp. 101-111
    • Molloy, A.M.1    Kirke, P.N.2    Brody, L.C.3    Scott, J.M.4    Mills, J.L.5
  • 2
    • 0028863219 scopus 로고
    • Folate levels and neural tube defects. Implications for prevention
    • Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM, (1995) Folate levels and neural tube defects. Implications for prevention. JAMA 274: 1698-1702.
    • (1995) JAMA , vol.274 , pp. 1698-1702
    • Daly, L.E.1    Kirke, P.N.2    Molloy, A.3    Weir, D.G.4    Scott, J.M.5
  • 3
    • 84855924761 scopus 로고    scopus 로고
    • Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
    • Hooshmand B, Solomon A, Kareholt I, Rusanen M, Hanninen T, et al. (2012) Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study. J Intern Med 271: 204-212.
    • (2012) J Intern Med , vol.271 , pp. 204-212
    • Hooshmand, B.1    Solomon, A.2    Kareholt, I.3    Rusanen, M.4    Hanninen, T.5
  • 4
    • 84858279062 scopus 로고    scopus 로고
    • Association between folate intake and melancholic depressive symptoms. A Finnish population-based study
    • Seppala J, Koponen H, Kautiainen H, Eriksson JG, Kampman O, et al. (2012) Association between folate intake and melancholic depressive symptoms. A Finnish population-based study. J Affect Disord 138: 473-478.
    • (2012) J Affect Disord , vol.138 , pp. 473-478
    • Seppala, J.1    Koponen, H.2    Kautiainen, H.3    Eriksson, J.G.4    Kampman, O.5
  • 8
    • 34250197957 scopus 로고    scopus 로고
    • Folate and colorectal cancer: an evidence-based critical review
    • Kim YI, (2007) Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 51: 267-292.
    • (2007) Mol Nutr Food Res , vol.51 , pp. 267-292
    • Kim, Y.I.1
  • 9
    • 0034800283 scopus 로고    scopus 로고
    • Beneficial role for folate in the prevention of colorectal and breast cancer
    • Prinz-Langenohl R, Fohr I, Pietrzik K, (2001) Beneficial role for folate in the prevention of colorectal and breast cancer. Eur J Nutr 40: 98-105.
    • (2001) Eur J Nutr , vol.40 , pp. 98-105
    • Prinz-Langenohl, R.1    Fohr, I.2    Pietrzik, K.3
  • 10
    • 77956594364 scopus 로고    scopus 로고
    • Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study
    • Ericson U, Borgquist S, Ivarsson MI, Sonestedt E, Gullberg B, et al. (2010) Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study. J Nutr 140: 1661-1668.
    • (2010) J Nutr , vol.140 , pp. 1661-1668
    • Ericson, U.1    Borgquist, S.2    Ivarsson, M.I.3    Sonestedt, E.4    Gullberg, B.5
  • 11
    • 71749111560 scopus 로고    scopus 로고
    • Cancer incidence and mortality after treatment with folic acid and vitamin B12
    • Ebbing M, Bonaa KH, Nygard O, Arnesen E, Ueland PM, et al. (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 302: 2119-2126.
    • (2009) JAMA , vol.302 , pp. 2119-2126
    • Ebbing, M.1    Bonaa, K.H.2    Nygard, O.3    Arnesen, E.4    Ueland, P.M.5
  • 12
    • 80051551995 scopus 로고    scopus 로고
    • A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
    • Chuang S-C, Stolzenberg-Solomon R, Ueland PM, Vollset SE, Midttun Ø, et al. (2011) A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. European Journal of Cancer 47: 1808-1816.
    • (2011) European Journal of Cancer , vol.47 , pp. 1808-1816
    • Chuang, S.-C.1    Stolzenberg-Solomon, R.2    Ueland, P.M.3    Vollset, S.E.4    Midttun, Ø.5
  • 14
    • 79960738319 scopus 로고    scopus 로고
    • Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate
    • Tomaszewski JJ, Cummings JL, Parwani AV, Dhir R, Mason JB, et al. (2011) Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate. Prostate 71: 1287-1293.
    • (2011) Prostate , vol.71 , pp. 1287-1293
    • Tomaszewski, J.J.1    Cummings, J.L.2    Parwani, A.V.3    Dhir, R.4    Mason, J.B.5
  • 15
    • 36248946255 scopus 로고    scopus 로고
    • Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age
    • Pietrzik K, Lamers Y, Bramswig S, Prinz-Langenohl R, (2007) Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age. Am J Clin Nutr 86: 1414-1419.
    • (2007) Am J Clin Nutr , vol.86 , pp. 1414-1419
    • Pietrzik, K.1    Lamers, Y.2    Bramswig, S.3    Prinz-Langenohl, R.4
  • 17
    • 0023911823 scopus 로고
    • Chemical synthesis of deuterated folate monoglutamate and in vivo assessment of urinary excretion of deuterated folates in man
    • Gregory JF, Toth JP, (1988) Chemical synthesis of deuterated folate monoglutamate and in vivo assessment of urinary excretion of deuterated folates in man. Analytical Biochemistry 170: 94-104.
    • (1988) Analytical Biochemistry , vol.170 , pp. 94-104
    • Gregory, J.F.1    Toth, J.P.2
  • 18
    • 0026496458 scopus 로고
    • The quantitative analysis of endogenous folate catabolites in human urine
    • McPartlin J, Courtney G, McNulty H, Weir D, Scott J, (1992) The quantitative analysis of endogenous folate catabolites in human urine. Anal Biochem 206: 256-261.
    • (1992) Anal Biochem , vol.206 , pp. 256-261
    • McPartlin, J.1    Courtney, G.2    McNulty, H.3    Weir, D.4    Scott, J.5
  • 20
    • 59049105095 scopus 로고    scopus 로고
    • Dietary folate intake, blood folate status, and urinary folate catabolite excretion in Korean women of childbearing age
    • Kim HA, Lim HS, (2008) Dietary folate intake, blood folate status, and urinary folate catabolite excretion in Korean women of childbearing age. J Nutr Sci Vitaminol (Tokyo) 54: 291-297.
    • (2008) J Nutr Sci Vitaminol (Tokyo) , vol.54 , pp. 291-297
    • Kim, H.A.1    Lim, H.S.2
  • 21
    • 77950124657 scopus 로고    scopus 로고
    • Estimation of 24-hour sodium excretion from spot urine samples
    • Mann SJ, Gerber LM, (2010) Estimation of 24-hour sodium excretion from spot urine samples. J Clin Hypertens (Greenwich) 12: 174-180.
    • (2010) J Clin Hypertens (Greenwich) , vol.12 , pp. 174-180
    • Mann, S.J.1    Gerber, L.M.2
  • 22
    • 0034452290 scopus 로고    scopus 로고
    • An evaluation of 24-hour urinary creatinine excretion for use in identification of incomplete urine collections and adjustment of absorbed dose of pesticides
    • Harris SA, Purdham JT, Corey PN, Sass-Kortsak AM, (2000) An evaluation of 24-hour urinary creatinine excretion for use in identification of incomplete urine collections and adjustment of absorbed dose of pesticides. AIHAJ 61: 649-657.
    • (2000) AIHAJ , vol.61 , pp. 649-657
    • Harris, S.A.1    Purdham, J.T.2    Corey, P.N.3    Sass-Kortsak, A.M.4
  • 23
    • 77649187983 scopus 로고    scopus 로고
    • Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays
    • Mönch S, Netzel M, Netzel G, Rychlik M, (2010) Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays. Anal Biochem 398: 150-160.
    • (2010) Anal Biochem , vol.398 , pp. 150-160
    • Mönch, S.1    Netzel, M.2    Netzel, G.3    Rychlik, M.4
  • 27
    • 32244445607 scopus 로고    scopus 로고
    • Simple method for the quantitative analysis of endogenous folate catabolites p-aminobenzoylglutamate (pABG) and its acetamido (apABG) derivative in human serum and urine by liquid chromatography-tandem mass spectrometry
    • Sokoro AA, Etter ML, Lepage J, Weist B, Eichhorst J, et al. (2006) Simple method for the quantitative analysis of endogenous folate catabolites p-aminobenzoylglutamate (pABG) and its acetamido (apABG) derivative in human serum and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 832: 9-16.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.832 , pp. 9-16
    • Sokoro, A.A.1    Etter, M.L.2    Lepage, J.3    Weist, B.4    Eichhorst, J.5
  • 29
    • 0023262020 scopus 로고
    • Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation
    • Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, et al. (1987) Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med 106: 707-710.
    • (1987) Ann Intern Med , vol.106 , pp. 707-710
    • Matchar, D.B.1    Feussner, J.R.2    Millington, D.S.3    Wilkinson Jr., R.H.4    Watson, D.J.5
  • 30
    • 0026544977 scopus 로고
    • Microbiological assay on microtitre plates of folate in serum and red cells
    • O'Broin S, Kelleher B, (1992) Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol 45: 344-347.
    • (1992) J Clin Pathol , vol.45 , pp. 344-347
    • O'Broin, S.1    Kelleher, B.2
  • 31
    • 79959945923 scopus 로고    scopus 로고
    • Increased serum gamma-glutamyltransferase activity in patients with metabolic syndrome
    • Bozbas H, Yildirir A, Karacaglar E, Demir O, Ulus T, et al. (2011) Increased serum gamma-glutamyltransferase activity in patients with metabolic syndrome. Turk Kardiyol Dern Ars 39: 122-128.
    • (2011) Turk Kardiyol Dern Ars , vol.39 , pp. 122-128
    • Bozbas, H.1    Yildirir, A.2    Karacaglar, E.3    Demir, O.4    Ulus, T.5
  • 32
    • 0031031304 scopus 로고    scopus 로고
    • Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men
    • Stites TE, Bailey LB, Scott KC, Toth JP, Fisher WP, et al. (1997) Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am J Clin Nutr 65: 53-60.
    • (1997) Am J Clin Nutr , vol.65 , pp. 53-60
    • Stites, T.E.1    Bailey, L.B.2    Scott, K.C.3    Toth, J.P.4    Fisher, W.P.5
  • 33
  • 34
    • 0034533199 scopus 로고    scopus 로고
    • Urinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women
    • Gregory JF III, Swendseid ME, Jacob RA, (2000) Urinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women. J Nutr 130: 2949-2952.
    • (2000) J Nutr , vol.130 , pp. 2949-2952
    • Gregory III, J.F.1    Swendseid, M.E.2    Jacob, R.A.3
  • 35
    • 0031794154 scopus 로고    scopus 로고
    • Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools
    • Gregory JF III, Williamson J, Liao JF, Bailey LB, Toth JP, (1998) Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools. J Nutr 128: 1896-1906.
    • (1998) J Nutr , vol.128 , pp. 1896-1906
    • Gregory III, J.F.1    Williamson, J.2    Liao, J.F.3    Bailey, L.B.4    Toth, J.P.5
  • 37
    • 0036714254 scopus 로고    scopus 로고
    • Consumption of the folate breakdown product para-aminobenzoylglutamate contributes minimally to urinary folate catabolite excretion in humans: investigation using [(13)C(5)]para-aminobenzoylglutamate
    • Caudill MA, Bailey LB, Gregory JF III, (2002) Consumption of the folate breakdown product para-aminobenzoylglutamate contributes minimally to urinary folate catabolite excretion in humans: investigation using [(13)C(5)]para-aminobenzoylglutamate. J Nutr 132: 2613-2616.
    • (2002) J Nutr , vol.132 , pp. 2613-2616
    • Caudill, M.A.1    Bailey, L.B.2    Gregory III, J.F.3
  • 38
    • 0028972358 scopus 로고
    • Para-acetamidobenzoylglutamate is a suitable indicator of folate catabolism in rats
    • Geoghegan FL, McPartlin JM, Weir DG, Scott JM, (1995) Para-acetamidobenzoylglutamate is a suitable indicator of folate catabolism in rats. J Nutr 125: 2563-2570.
    • (1995) J Nutr , vol.125 , pp. 2563-2570
    • Geoghegan, F.L.1    McPartlin, J.M.2    Weir, D.G.3    Scott, J.M.4
  • 40
    • 77953719953 scopus 로고    scopus 로고
    • Automated determination of folate catabolites in human biofluids (urine, breast milk and serum) by on-line SPE-HILIC-MS/MS
    • Alvarez-Sanchez B, Priego-Capote F, Mata-Granados JM, Luque de Castro MD (2010) Automated determination of folate catabolites in human biofluids (urine, breast milk and serum) by on-line SPE-HILIC-MS/MS. J Chromatogr A.
    • (2010) J Chromatogr A
    • Alvarez-Sanchez, B.1    Priego-Capote, F.2    Mata-Granados, J.M.3    Luque de Castro, M.D.4
  • 41
    • 0031941173 scopus 로고    scopus 로고
    • Folate catabolism in pregnant and nonpregnant women with controlled folate intakes
    • Caudill MA, Gregory JF, Hutson AD, Bailey LB, (1998) Folate catabolism in pregnant and nonpregnant women with controlled folate intakes. J Nutr 128: 204-208.
    • (1998) J Nutr , vol.128 , pp. 204-208
    • Caudill, M.A.1    Gregory, J.F.2    Hutson, A.D.3    Bailey, L.B.4
  • 43
    • 79953718498 scopus 로고    scopus 로고
    • Folic acid food fortification-its history, effect, concerns, and future directions
    • Crider KS, Bailey LB, Berry RJ, (2011) Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients 3: 370-384.
    • (2011) Nutrients , vol.3 , pp. 370-384
    • Crider, K.S.1    Bailey, L.B.2    Berry, R.J.3
  • 44
    • 79959387320 scopus 로고    scopus 로고
    • Long-term effect of low-dose folic acid intake: potential effect of mandatory fortification on the prevention of neural tube defects
    • Houghton LA, Gray AR, Rose MC, Miller JC, Hurthouse NA, et al. (2011) Long-term effect of low-dose folic acid intake: potential effect of mandatory fortification on the prevention of neural tube defects. Am J Clin Nutr 94: 136-141.
    • (2011) Am J Clin Nutr , vol.94 , pp. 136-141
    • Houghton, L.A.1    Gray, A.R.2    Rose, M.C.3    Miller, J.C.4    Hurthouse, N.A.5
  • 46
    • 49449083782 scopus 로고    scopus 로고
    • Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial
    • Hao L, Yang QH, Li Z, Bailey LB, Zhu JH, et al. (2008) Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial. Am J Clin Nutr 88: 448-457.
    • (2008) Am J Clin Nutr , vol.88 , pp. 448-457
    • Hao, L.1    Yang, Q.H.2    Li, Z.3    Bailey, L.B.4    Zhu, J.H.5
  • 47
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
    • Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, et al. (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128: 1204-1212.
    • (1998) J Nutr , vol.128 , pp. 1204-1212
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3    James, S.J.4    Pogribny, I.P.5
  • 48
    • 0034938814 scopus 로고    scopus 로고
    • Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools
    • Gregory JF III, Caudill MA, Opalko FJ, Bailey LB, (2001) Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools. J Nutr 131: 1928-1937.
    • (2001) J Nutr , vol.131 , pp. 1928-1937
    • Gregory III, J.F.1    Caudill, M.A.2    Opalko, F.J.3    Bailey, L.B.4
  • 49
    • 77249107069 scopus 로고    scopus 로고
    • Analytical recovery of folate and its degradation products in human serum stored at -25 degrees C for up to 29 years
    • Hannisdal R, Gislefoss RE, Grimsrud TK, Hustad S, Morkrid L, et al. (2010) Analytical recovery of folate and its degradation products in human serum stored at -25 degrees C for up to 29 years. J Nutr 140: 522-526.
    • (2010) J Nutr , vol.140 , pp. 522-526
    • Hannisdal, R.1    Gislefoss, R.E.2    Grimsrud, T.K.3    Hustad, S.4    Morkrid, L.5
  • 50
    • 0027322524 scopus 로고
    • Urinary excretion of deuterium-labeled folate and the metabolite p-aminobenzoylglutamate in humans
    • Kownacki-Brown PA, Wang C, Bailey LB, Toth JP, Gregory JF III, (1993) Urinary excretion of deuterium-labeled folate and the metabolite p-aminobenzoylglutamate in humans. J Nutr 123: 1101-1108.
    • (1993) J Nutr , vol.123 , pp. 1101-1108
    • Kownacki-Brown, P.A.1    Wang, C.2    Bailey, L.B.3    Toth, J.P.4    Gregory III, J.F.5
  • 51
    • 0035848341 scopus 로고    scopus 로고
    • Randomized trial of folic acid supplementation and serum homocysteine levels
    • Wald DS, Bishop L, Wald NJ, Law M, Hennessy E, et al. (2001) Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 161: 695-700.
    • (2001) Arch Intern Med , vol.161 , pp. 695-700
    • Wald, D.S.1    Bishop, L.2    Wald, N.J.3    Law, M.4    Hennessy, E.5
  • 52
    • 0033039304 scopus 로고    scopus 로고
    • Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12
    • Lobo A, Naso A, Arheart K, Kruger WD, Abou-Ghazala T, et al. (1999) Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12. The American journal of cardiology 83: 821-825.
    • (1999) The American Journal of Cardiology , vol.83 , pp. 821-825
    • Lobo, A.1    Naso, A.2    Arheart, K.3    Kruger, W.D.4    Abou-Ghazala, T.5
  • 53
    • 0034530033 scopus 로고    scopus 로고
    • Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet
    • McKay DL, Perrone G, Rasmussen H, Dallal G, Blumberg JB, (2000) Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. J Nutr 130: 3090-3096.
    • (2000) J Nutr , vol.130 , pp. 3090-3096
    • McKay, D.L.1    Perrone, G.2    Rasmussen, H.3    Dallal, G.4    Blumberg, J.B.5
  • 54
    • 82755161008 scopus 로고    scopus 로고
    • Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study
    • Bart S Sr, Marr J, Diefenbach K, Trummer D, Sampson-Landers C, (2012) Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study. Contraception 85: 42-50.
    • (2012) Contraception , vol.85 , pp. 42-50
    • Bart Sr., S.1    Marr, J.2    Diefenbach, K.3    Trummer, D.4    Sampson-Landers, C.5
  • 56
    • 0037639877 scopus 로고    scopus 로고
    • Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications
    • Schulze A, Lindner M, Kohlmuller D, Olgemoller K, Mayatepek E, et al. (2003) Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications. Pediatrics 111: 1399-1406.
    • (2003) Pediatrics , vol.111 , pp. 1399-1406
    • Schulze, A.1    Lindner, M.2    Kohlmuller, D.3    Olgemoller, K.4    Mayatepek, E.5


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