Interaction of an aluminium-magnesium containing antacid and gastric mucus: Possible contribution to the cytoprotective function of antacids

Alimentary Pharmacology and Therapeutics

Volumn 11, Issue 1, 1997, Pages 139-145

  Grubel P ^a   Bhaskar, K R ^b   Cave, D R ^a   Garik, P ^c   Stanley, H E ^c   Lamont, J T ^b  

^a ST ELIZABETH'S MEDICAL CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; ANTACID AGENT; HYDROTALCITE; ALMAGATE; ALUMINUM HYDROXIDE; CARBONIC ACID DERIVATIVE; HYDROCHLORIC ACID; MAGNESIUM HYDROXIDE;

ANIMAL TISSUE; ARTICLE; CELL PROTECTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STOMACH ACID SECRETION; STOMACH MUCOSA; SWINE; VISCOSITY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DIFFUSION; DRUG EFFECT; MUCUS; PH;

ALUMINUM HYDROXIDE; ANIMALS; ANTACIDS; CARBONATES; DIFFUSION; GASTRIC MUCOSA; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; MAGNESIUM HYDROXIDE; MUCUS; SWINE; VISCOSITY;

EID: 0030614717     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1997.104275000.x     Document Type: Article

References (28)

1. Tarnawski A, Hollander D, Cummings D, Krause WJ, Cergely H, Zipser RD. Are antacids neutralizers only? Histologic, ultrastructural and functional changes in normal gastric mucosa induced by antacids. Gastroenterology 1984; 86: 1276-81.
2. Hollander D, Tarnawski A, Gergely H. Protection against alcohol-induced gastric mucosal injury by aluminium-containing compounds sucralfate, antacids and aluminium sulfate. Scand J Gastroenterol 1986; 21: 151-3.
3. Priebe JH, Skillman JJ, Bushnell LS, Long PC, Silen W. Antacids versus cimetidine in preventing acute gastrointestinal bleeding: a randomized trial in 75 critically ill patients. N Engl J Med 1980; 302: 426-30.
4. Peterson WI, Surdevant AL, Frankl HD, et al. Healing of duodenal ulcer with an antacid regimen. N Engl J Med 1977; 297: 341-5.
5. Berstad A, Rydning A, Aaland E, Kolstad B, Frislid K, Asseth J. Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scand J Gastroenterol 1982; 17: 953-9.
6. Bianchi-Porro G, Lazzaroni M, Pace F, Petrillo M, Long-term low dose antacid versus cimetidine therapy in the treatment of duodenal ulcer recurrence. Scand J Gastroenterol 1986; 21: 1144-6.
7. Allen A. Structure and function of gastrointestinal mucus. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven. 1981: 617-39.
8. Hollander F. The two-component mucus barrier. Arch Intern Med 1954; 93: 107-20.
9. Healey NG. Some experiments on partially purified gastrointestinal mucosubstance. Gastroenterology 1958; 37: 304-12.
10. Allen A, Flemström G, Garner A, Kivilaakso E. Gastroduodenal mucosal protection. Physiol Rev 1993; 73: 823-57.
11. Bhaskar KR, Gong D, Bansil R, et al. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol 1991 ; 261 : G827-32.
12. Bhaskar KR, Garik P, Turner BS, et al Viscous fingering of HCI through gastric mucin. Nature 1992; 360: 458-61.
13. Robinson AL. Fractal fingers in viscous fluids. Science 1985; 228: 1077-80.
14. Robinson AL. When are viscous fingers stable? Science 1985; 228: 834-6.
15. Nittmann J, Daccord G, Stanley HE. Fractal growth of viscous fingers: quantitative characterization of a fluid instability phenomenon. Nature 1985; 314: 141-4.
16. Ben-Jacob E, Garik P. The formation of patterns in nonequilibrium growth. Nature 1990; 343: 523-30.
17. Bansil R, Stanley HE, LaMont JT. Mucin biophysics. Annu Rev Physiol 1995; 57: 635-57.
18. Gong D, Turner B, Bhaskar KR, LaMont JT. Lipid binding to gastric mucin: protective effect against oxygen radicals. Am J Physiol 1990; 259: G681-6.
19. Smith BF, LaMont JT. Hydrophobic binding properties of bovine gallbladder mucin. J Biol Chem 1984; 259: 12170-7.
20. Fordtran JS, Morawski SG, Richardson CS. In vivo and in vitro evaluation of liquid antacids. N Engl J Med 1973; 288: 923-8.
21. MacLean-Fletcher SD, Pollard TD. Viscometric analysis of the gelation of Acanthamoeba extracts and purification of two gelation factors. J Cell Biol 1980; 85: 414-8.
22. Holm L, Flemström G. Microscopy of acid transport at the gastric surface in vivo. J Int Med 1990; 228: 91-5.
23. Mortazavi SA, Smart JD. Factors influencing gel-strengthening at the mucoadhesive-mucus interface. J Pharm Pharmacol 1994; 46: 86-90.
24. Allen A, Foster SNE, Pearson JP. Interaction of a polyacrylate. carbomer. with gastric mucin and pepsin. Br J Pharmacol 1987; 126P.
25. Mortazavi SA, Carpenter B, Smart JD. A comparative study on the role played by mucus glycoproteins in the rheological behaviour of the mucoadhesive/mucosal interface. Int J Pharm 1993; 94: 195-201.
26. Schade C, Flemström G, Holm L. Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa. Gastroenterology 1994; 107: 180-8.
27. Makhlouf GM. Isolated smooth muscle cell of the gut. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven, 1987: 555-69.
28. Kerss S, Allen A, Garner A. A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, N-acethylcysteine and other agents. Clin Sci 1982; 63: 187-95.