메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 205-210

Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway

Author keywords

Conversion; Galectin 9; Phosphorylation; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; ECALECTIN; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84873873456     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1125     Document Type: Article
Times cited : (32)

References (38)
  • 1
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352, 2005.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 3
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY and Flavell RA: Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445: 766-770, 2007.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 5
    • 2142645808 scopus 로고    scopus 로고
    • + T cells through Foxp3 induction and down-regulation of Smad7
    • + T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-5153, 2004.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3
  • 6
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 198: 1875-1886, 2003.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 7
    • 33847337912 scopus 로고    scopus 로고
    • + T regulatory cells: Role of tumor-derived TGF-β
    • + T regulatory cells: role of tumor-derived TGF-β. J Immunol 178: 2883-2892, 2007.
    • (2007) J Immunol , vol.178 , pp. 2883-2892
    • Liu, V.C.1    Wong, L.Y.2    Jang, T.3
  • 8
    • 12344307563 scopus 로고    scopus 로고
    • + regulatory T cells invivo requires B7 costimulation, but not the thymus
    • + regulatory T cells invivo requires B7 costimulation, but not the thymus. J Exp Med 201: 127-137, 2005.
    • (2005) J Exp Med , vol.201 , pp. 127-137
    • Liang, S.1    Alard, P.2    Zhao, Y.3
  • 9
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B, Lohr J, Kahn E, etal: Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202: 1375-1386, 2005.
    • (2005) J Exp Med , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3
  • 11
    • 33846923124 scopus 로고    scopus 로고
    • 3+ regulatory T cells and for expansion of these cells
    • 3+ regulatory T cells and for expansion of these cells. J Immunol 178: 2018-2027, 2007.
    • (2007) J Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3
  • 12
    • 49649107703 scopus 로고    scopus 로고
    • DNA methylation controls Foxp3 gene expression
    • Polansky JK, Kretschmer K, Freyer J, etal: DNA methylation controls Foxp3 gene expression. Eur J Immunol 38: 1654-1663, 2008.
    • (2008) Eur J Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1    Kretschmer, K.2    Freyer, J.3
  • 13
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, etal: Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease. Nature 359: 693-699, 1992.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 14
    • 0027531528 scopus 로고
    • Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, Huh CG, Becker D, etal: Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90: 770-774, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3
  • 15
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β II receptor
    • Lucas PJ, Kim SJ, Melby SJ, etal: Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β II receptor. J Exp Med 191: 1187-1196, 2000.
    • (2000) J Exp Med , vol.191 , pp. 1187-1196
    • Lucas, P.J.1    Kim, S.J.2    Melby, S.J.3
  • 16
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGF β signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L and Flavell RA: Abrogation of TGF β signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12: 171-181, 2000.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 17
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms
    • Li MO, Sanjabi S and Flavell RA: Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms. Immunity 25: 455-471, 2006.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 20
    • 18444398329 scopus 로고    scopus 로고
    • Association of galectin-9 with eosinophil apoptosis
    • Saita N, Goto E, Yamamoto T, etal: Association of galectin-9 with eosinophil apoptosis. Int Arch Allergy Immunol 128: 42-50, 2002.
    • (2002) Int Arch Allergy Immunol , vol.128 , pp. 42-50
    • Saita, N.1    Goto, E.2    Yamamoto, T.3
  • 21
    • 0037142179 scopus 로고    scopus 로고
    • Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance
    • Kageshita T, Kashio Y and Yamauchi A: Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. Int J Cancer 99: 809-816, 2002.
    • (2002) Int J Cancer , vol.99 , pp. 809-816
    • Kageshita, T.1    Kashio, Y.2    Yamauchi, A.3
  • 22
    • 0030989330 scopus 로고    scopus 로고
    • Developmental regulation, expression, and apoptotic potential of galectin-9, a β-galactoside binding lectin
    • Wada J, Ota K, Kumar A, etal: Developmental regulation, expression, and apoptotic potential of galectin-9, a β-galactoside binding lectin. J Clin Invest 99: 2452-2461, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 2452-2461
    • Wada, J.1    Ota, K.2    Kumar, A.3
  • 23
    • 0032479178 scopus 로고    scopus 로고
    • A variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes
    • Matsumoto R, Matsumoto H, Seki M, etal: A variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J Biol Chem 273: 16976-16984, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 16976-16984
    • Matsumoto, R.1    Matsumoto, H.2    Seki, M.3
  • 24
    • 0037377942 scopus 로고    scopus 로고
    • Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway
    • Kashio Y, Nakamura K and Abedin MJ: Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol 170: 3631-3636, 2003.
    • (2003) J Immunol , vol.170 , pp. 3631-3636
    • Kashio, Y.1    Nakamura, K.2    Abedin, M.J.3
  • 25
    • 30044434075 scopus 로고    scopus 로고
    • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    • Zhu C, Anderson AC, Schubart A, etal: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6: 1245-1252, 2005.
    • (2005) Nat Immunol , vol.6 , pp. 1245-1252
    • Zhu, C.1    Anderson, A.C.2    Schubart, A.3
  • 26
    • 34447298335 scopus 로고    scopus 로고
    • Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes
    • Tsuboi Y, Abe H, Nakagawa R, etal: Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. Clin Immunol 124: 221-233, 2007.
    • (2007) Clin Immunol , vol.124 , pp. 221-233
    • Tsuboi, Y.1    Abe, H.2    Nakagawa, R.3
  • 27
    • 42449097229 scopus 로고    scopus 로고
    • Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice
    • Fukushima, Tamaki S and Fukuda K: Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice. Int Arch Allergy Immunol 146: 36-43, 2008.
    • (2008) Int Arch Allergy Immunol , vol.146 , pp. 36-43
    • Fukushima1    Tamaki, S.2    Fukuda, K.3
  • 28
    • 40849120400 scopus 로고    scopus 로고
    • Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
    • Seki M, Oomizu S, Sakata K, etal: Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127: 78-88, 2008.
    • (2008) Clin Immunol , vol.127 , pp. 78-88
    • Seki, M.1    Oomizu, S.2    Sakata, K.3
  • 29
    • 64849111809 scopus 로고    scopus 로고
    • Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: Shifting the balance toward regulators
    • Sharvan S, Amol S, Hirashima M, etal: Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J Immunol 182: 3191-3201, 2009.
    • (2009) J Immunol , vol.182 , pp. 3191-3201
    • Sharvan, S.1    Amol, S.2    Hirashima, M.3
  • 30
    • 79958710291 scopus 로고    scopus 로고
    • Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells
    • Lv K, Xu W, Wang CN, etal: Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells. Clin Immunol 140: 92-101, 2011.
    • (2011) Clin Immunol , vol.140 , pp. 92-101
    • Lv, K.1    Xu, W.2    Wang, C.N.3
  • 31
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 33
    • 33646239606 scopus 로고    scopus 로고
    • +CD25-lymphocytes is thymus and proliferation independent
    • +CD25-lymphocytes is thymus and proliferation independent. Cancer Res 66: 4488-4495, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4488-4495
    • Valzasina, B.1    Piconese, S.2    Guiducci, C.3
  • 34
    • 33646251141 scopus 로고    scopus 로고
    • 3+ regulatory T cells suppress Th1 mediated experimental colitis
    • 3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 55: 671-680, 2006.
    • (2006) Gut , vol.55 , pp. 671-680
    • Fantini, M.C.1    Becker, C.2    Tubbe, I.3
  • 35
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J: How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1: 169-178, 2000.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massague, J.1
  • 36
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J: TGF-beta signal transduction. Annu Rev Biochem 67: 753-791, 1998.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 37
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague J and Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 1998.
    • (1998) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 38
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J and Wotton D: Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754, 2000.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.