메뉴 건너뛰기




Volumn 7, Issue 2, 2013, Pages 537-542

Putative role of the mTOR/4E-BP1 signaling pathway in the carcinogenesis and progression of gastric cardiac adenocarcinoma

Author keywords

4E BP1; EIF4E; Gastric cardiac adenocarcinoma; MTOR

Indexed keywords

INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA;

EID: 84873862324     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1208     Document Type: Article
Times cited : (15)

References (37)
  • 1
    • 4143121436 scopus 로고    scopus 로고
    • Treatment of metastatic esophagus and gastric cancer
    • Shah MA and Schwartz GK: Treatment of metastatic esophagus and gastric cancer. Semin Oncol 31: 574-587, 2004.
    • (2004) Semin Oncol , vol.31 , pp. 574-587
    • Shah, M.A.1    Schwartz, G.K.2
  • 3
    • 77952976124 scopus 로고    scopus 로고
    • Analysis of the changing trends of frequency and localization of gastric cancers arising from different sites of the stomach in population of the high incidence area of esophageal and gastric cancers in Hebei province
    • In Chinese
    • Zhao CY, Zhang XH, Xue LY, Xing LX, Wang JL, Li XM, et al: Analysis of the changing trends of frequency and localization of gastric cancers arising from different sites of the stomach in population of the high incidence area of esophageal and gastric cancers in Hebei province. Zhonghua Zhong Liu Za Zhi 30: 817-820, 2008 (In Chinese).
    • (2008) Zhonghua Zhong Liu Za Zhi , vol.30 , pp. 817-820
    • Zhao, C.Y.1    Zhang, X.H.2    Xue, L.Y.3    Xing, L.X.4    Wang, J.L.5    Li, X.M.6
  • 4
    • 33847225199 scopus 로고    scopus 로고
    • Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach
    • Tajima Y, Yamazaki K, Makino R, Nishino N, Masuda Y, Aoki S, et al: Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach. Br J Cancer 96: 631-638, 2007.
    • (2007) Br J Cancer , vol.96 , pp. 631-638
    • Tajima, Y.1    Yamazaki, K.2    Makino, R.3    Nishino, N.4    Masuda, Y.5    Aoki, S.6
  • 5
    • 44949112425 scopus 로고    scopus 로고
    • Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
    • Faried LS, Faried A, Kanuma T, Aoki H, Sano T, Nakazato T, et al: Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy. Mol Carcinog 47: 446-457, 2008.
    • (2008) Mol Carcinog , vol.47 , pp. 446-457
    • Faried, L.S.1    Faried, A.2    Kanuma, T.3    Aoki, H.4    Sano, T.5    Nakazato, T.6
  • 6
    • 33745095268 scopus 로고    scopus 로고
    • Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
    • Albert JM, Kim KW, Cao C and Lu B: Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol Cancer Ther 5: 1183-1189, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1183-1189
    • Albert, J.M.1    Kim, K.W.2    Cao, C.3    Lu, B.4
  • 7
    • 65649120747 scopus 로고    scopus 로고
    • The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential
    • Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, et al: The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun 384: 471-475, 2009.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 471-475
    • Mori, H.1    Inoki, K.2    Masutani, K.3    Wakabayashi, Y.4    Komai, K.5    Nakagawa, R.6
  • 8
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC and Blenis J: Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171, 2004.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 9
    • 0345732640 scopus 로고    scopus 로고
    • MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C and Blenis J: mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24: 200-216, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 10
    • 70450221920 scopus 로고    scopus 로고
    • 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation
    • Azar R, Alard A, Susini C, Bousquet C and Pyronnet S: 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation. EMBO J 28: 3514-3522, 2009.
    • (2009) EMBO J , vol.28 , pp. 3514-3522
    • Azar, R.1    Alard, A.2    Susini, C.3    Bousquet, C.4    Pyronnet, S.5
  • 11
    • 73449095458 scopus 로고    scopus 로고
    • EIF4E-binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggs
    • Oulhen N, Mulner-Lorillon O and Cormier P: eIF4E-binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggs. Mol Reprod Dev 77: 83-91, 2010.
    • (2010) Mol Reprod Dev , vol.77 , pp. 83-91
    • Oulhen, N.1    Mulner-Lorillon, O.2    Cormier, P.3
  • 12
    • 33947099498 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
    • Lang SA, Gaumann A, Koehl GE, Seidel U, Bataille F, Klein D, et al: Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer 120: 1803-1810, 2007.
    • (2007) Int J Cancer , vol.120 , pp. 1803-1810
    • Lang, S.A.1    Gaumann, A.2    Koehl, G.E.3    Seidel, U.4    Bataille, F.5    Klein, D.6
  • 13
    • 84862824218 scopus 로고    scopus 로고
    • Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum
    • Yoon DH, Ryu MH, Park YS, Lee HJ, Lee C, Ryoo BY, et al: Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum. Br J Cancer 106: 1039-1044, 2012.
    • (2012) Br J Cancer , vol.106 , pp. 1039-1044
    • Yoon, D.H.1    Ryu, M.H.2    Park, Y.S.3    Lee, H.J.4    Lee, C.5    Ryoo, B.Y.6
  • 14
    • 0031784518 scopus 로고    scopus 로고
    • Classification of adenocarcinoma of the oesophagogastric junction
    • Siewert JR and Stein HJ: Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 85: 1457-1459, 1998.
    • (1998) Br J Surg , vol.85 , pp. 1457-1459
    • Siewert, J.R.1    Stein, H.J.2
  • 15
    • 77952311165 scopus 로고    scopus 로고
    • Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer
    • Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, et al: Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. J Am Coll Surg 210: 767-776, 2010.
    • (2010) J Am Coll Surg , vol.210 , pp. 767-776
    • Johnson, S.M.1    Gulhati, P.2    Rampy, B.A.3    Han, Y.4    Rychahou, P.G.5    Doan, H.Q.6
  • 16
    • 76049097260 scopus 로고    scopus 로고
    • Activation of mTOR in renal cell carcinoma is due to increased phosphorylation rather than protein overexpression
    • Kruck S, Bedke J, Hennenlotter J, Ohneseit PA, Kuehs U, Senger E, et al: Activation of mTOR in renal cell carcinoma is due to increased phosphorylation rather than protein overexpression. Oncol Rep 23: 159-163, 2010.
    • (2010) Oncol Rep , vol.23 , pp. 159-163
    • Kruck, S.1    Bedke, J.2    Hennenlotter, J.3    Ohneseit, P.A.4    Kuehs, U.5    Senger, E.6
  • 17
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou X, Tan M, Stone Hawthorne V, Klos KS, Lan KH, Yang Y, et al: Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res 10: 6779-6788, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone Hawthorne, V.3    Klos, K.S.4    Lan, K.H.5    Yang, Y.6
  • 18
    • 77949281423 scopus 로고    scopus 로고
    • Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
    • Ji J and Zheng PS: Activation of mTOR signaling pathway contributes to survival of cervical cancer cells. Gynecol Oncol 117: 103-108, 2010.
    • (2010) Gynecol Oncol , vol.117 , pp. 103-108
    • Ji, J.1    Zheng, P.S.2
  • 19
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G and Raymond E: Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 5: 671-688, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 20
    • 0742269398 scopus 로고    scopus 로고
    • Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45
    • Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K and Ito H: Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J Cancer Res Clin Oncol 130: 8-14, 2004.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 8-14
    • Osaki, M.1    Kase, S.2    Adachi, K.3    Takeda, A.4    Hashimoto, K.5    Ito, H.6
  • 21
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK and Testa JR: AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 23: 5853-5857, 2004.
    • (2004) Oncogene , vol.23 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3    De Rienzo, A.4    Klein-Szanto, A.J.5    Godwin, A.K.6    Testa, J.R.7
  • 22
    • 63549108509 scopus 로고    scopus 로고
    • Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer
    • Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, et al: Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. Clin Cancer Res 15: 1821-1829, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 1821-1829
    • Yu, G.1    Wang, J.2    Chen, Y.3    Wang, X.4    Pan, J.5    Li, G.6
  • 23
    • 61749085803 scopus 로고    scopus 로고
    • Relation between outcomes and localisation of p-mTOR expression in gastric cancer
    • Murayama T, Inokuchi M, Takagi Y, Yamada H, Kojima K, Kumagai J, et al: Relation between outcomes and localisation of p-mTOR expression in gastric cancer. Br J Cancer 100: 782-788, 2009.
    • (2009) Br J Cancer , vol.100 , pp. 782-788
    • Murayama, T.1    Inokuchi, M.2    Takagi, Y.3    Yamada, H.4    Kojima, K.5    Kumagai, J.6
  • 24
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E and Blenis J: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16: 1472-1487, 2002.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 25
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • Sabatini DM: mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6: 729-734, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 27
    • 34548028705 scopus 로고    scopus 로고
    • 4E-binding protein 1: A key molecular 'funnel factor' in human cancer with clinical implications
    • Armengol G, Rojo F, Castellvi J, Iglesias C, Cuatrecasas M, Pons B, et al: 4E-binding protein 1: a key molecular 'funnel factor' in human cancer with clinical implications. Cancer Res 67: 7551-7555, 2007.
    • (2007) Cancer Res , vol.67 , pp. 7551-7555
    • Armengol, G.1    Rojo, F.2    Castellvi, J.3    Iglesias, C.4    Cuatrecasas, M.5    Pons, B.6
  • 28
    • 66949159435 scopus 로고    scopus 로고
    • Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: Association with stage and grade in vivo and link with response to rapamycin treatment in vitro
    • Darb-Esfahani S, Faggad A, Noske A, Weichert W, Buckendahl AC, Müller B, et al: Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro. J Cancer Res Clin Oncol 135: 933-941, 2009.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 933-941
    • Darb-Esfahani, S.1    Faggad, A.2    Noske, A.3    Weichert, W.4    Buckendahl, A.C.5    Müller, B.6
  • 30
    • 71649084944 scopus 로고    scopus 로고
    • Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy
    • Benavente S, Vergés R, Hermosilla E, Fumanal V, Casanova N, García A, et al: Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy. Int J Radiat Oncol Biol Phys 75: 1316-1322, 2009.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 1316-1322
    • Benavente, S.1    Vergés, R.2    Hermosilla, E.3    Fumanal, V.4    Casanova, N.5    García, A.6
  • 32
    • 0024237848 scopus 로고
    • Cap-binding proteins of eukaryotic messenger RNA: Functions in initiation and control of translation
    • Sonenberg N: Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol 35: 173-207, 1988.
    • (1988) Prog Nucleic Acid Res Mol Biol , vol.35 , pp. 173-207
    • Sonenberg, N.1
  • 33
    • 0033044355 scopus 로고    scopus 로고
    • EIF4E expression in tumors: Its possible role in progression of malignancies
    • De Benedetti A and Harris AL: eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol 31: 59-72, 1999.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 59-72
    • De Benedetti, A.1    Harris, A.L.2
  • 34
    • 33846648989 scopus 로고    scopus 로고
    • Controlling gene expression through RNA regulons: The role of the eukaryotic translation initiation factor eIF4E
    • Culjkovic B, Topisirovic I and Borden KL: Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. Cell Cycle 6: 65-69, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 65-69
    • Culjkovic, B.1    Topisirovic, I.2    Borden, K.L.3
  • 35
    • 2342489456 scopus 로고    scopus 로고
    • EIF4E expression and its role in malignancies and metastases
    • De Benedetti A and Graff JR: eIF4E expression and its role in malignancies and metastases. Oncogene 23: 3189-3199, 2004.
    • (2004) Oncogene , vol.23 , pp. 3189-3199
    • De Benedetti, A.1    Graff, J.R.2
  • 36
    • 69949189840 scopus 로고    scopus 로고
    • Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma
    • Wang R, Geng J, Wang JH, Chu XY, Geng HC and Chen LB: Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma. Lung Cancer 66: 237-244, 2009.
    • (2009) Lung Cancer , vol.66 , pp. 237-244
    • Wang, R.1    Geng, J.2    Wang, J.H.3    Chu, X.Y.4    Geng, H.C.5    Chen, L.B.6
  • 37
    • 9244228003 scopus 로고    scopus 로고
    • Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities
    • Topisirovic I, Ruiz-Gutierrez M and Borden KL: Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res 64: 8639-8642, 2004.
    • (2004) Cancer Res , vol.64 , pp. 8639-8642
    • Topisirovic, I.1    Ruiz-Gutierrez, M.2    Borden, K.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.