(-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: Role of topoisomerase IIα inhibition and reactive oxygen species

Toxicology

Volumn 305, Issue , 2013, Pages 1-9

  Takeda, Shuso ^a   Noguchi, Momoko ^a   Matsuo, Kazumasa ^b   Yamaguchi, Yasuhiro ^a   Kudo, Taichi ^a   Nishimura, Hajime ^a   Okamoto, Yoshiko ^a   Amamoto, Toshiaki ^c   Shindo, Mitsuru ^b   Omiecinski, Curtis J ^d   Aramaki, Hironori ^a  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NEUES Corporation   (Japan)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Breast cancer; GADD45 ; ROS; Topoisomerase II ; Xanthatin

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); GADD45 GAMMA PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XANTHAN; XANTHATIN;

ARTICLE; BREAST CANCER; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; HUMAN; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING;

ACETYLCYSTEINE; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; FREE RADICAL SCAVENGERS; FURANS; GLUTATHIONE; HALF-LIFE; HUMANS; INSECTICIDES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TOPOISOMERASE II INHIBITORS; UP-REGULATION;

EID: 84873855734     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.12.019     Document Type: Article

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