(-)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells

Chemical Research in Toxicology

Volumn 24, Issue 6, 2011, Pages 855-865

  Takeda, Shuso ^a   Matsuo, Kazumasa ^b   Yaji, Kentaro ^b   Okajima Miyazaki, Shunsuke ^a   Harada, Mari ^a   Miyoshi, Hiroko ^a   Okamoto, Yoshiko ^a   Amamoto, Toshiaki ^c   Shindo, Mitsuru ^b   Omiecinski, Curtis J ^d   Aramaki, Hironori ^a  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NEUES Corporation   (Japan)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 EPI SUNDIVERSIFOLIDE; 8 EPI XANTHATIN; 8,11 EPI SUNDIVERSIFOLIDE; ANTINEOPLASTIC AGENT; CASPASE; DIHYDROXANTHATIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 GAMMA; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PLANT EXTRACT; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SUNDIVERSIFOLIDE; UNCLASSIFIED DRUG; XANTHATIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; SIGNAL TRANSDUCTION; XANTHIUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CASPASES; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; FEMALE; FURANS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEME OXYGENASE-1; HUMANS; INTERLEUKIN-18; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION; XANTHIUM;

XANTHIUM STRUMARIUM;

EID: 79959383004     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200046s     Document Type: Article

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