An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells

Biochemistry

Volumn 52, Issue 4, 2013, Pages 752-764

  Cai, Minying ^a   Stankova, Magda ^a   Muthu, Dhanasekaran ^a   Mayorov, Alexander ^a   Yang, Zhehui ^a   Trivedi, Devendra ^a   Cabello, Christopher ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVE PEPTIDES; C-TERMINUS; DRUG LEADS; HUMAN MEDICINE; IN-VIVO; MELANOMA CELLS; N-TERMINALS; RECEPTOR ANTAGONISTS; RECEPTOR BINDING; SIDE-CHAINS; THIOETHERS; TURN STRUCTURE; UNUSUAL CONFORMATIONS;

AMINO ACIDS; DERMATOLOGY; ONCOLOGY;

PEPTIDES;

AGOUTI PROTEIN; CYSTEINE; GAMMA INTERMEDIN DERIVATIVE; INTERMEDIN DERIVATIVE; MELANOCORTIN 1 RECEPTOR; PHENYLALANINE; SULFIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYCLIZATION; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GAMMA-MSH; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MELANOCYTE-STIMULATING HORMONES; MELANOMA; MOLECULAR DYNAMICS SIMULATION; MOLECULAR TARGETED THERAPY; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, MELANOCORTIN, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873818718     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300723f     Document Type: Article

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