Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays

Toxicon

Volumn 64, Issue , 2013, Pages 60-69

  Gutiérrez, José María ^a   Tsai, Wan Chih ^a   Pla, Davinia ^b   Solano, Gabriela ^a   Lomonte, Bruno ^a   Sanz, Libia ^b   Angulo, Yamileth ^a   Calvete, Juan J ^b,c  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Antivenom; Antivenomics; Cerrophidion; Neutralization; Porthidium; Snake venom

Indexed keywords

CERROPHIDION SASAI ANTIVENOM; DISINTEGRIN; IMMUNOGLOBULIN G ANTIBODY; METALLOPROTEINASE; PHOSPHOLIPASE A2; PORTHIDIUM NASUTUM ANTIVENOM; PORTHIDIUM OPHRYOMEGAS ANTIVENOM; PROTEINASE; SNAKE VENOM ANTISERUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIGEN RECOGNITION; ARTICLE; CENTRAL AMERICA; CERROPHIDION SASAI; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SPECIFICITY; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOGENICITY; IN VIVO STUDY; LETHALITY; MOLECULAR WEIGHT; MOUSE; MUSCLE DISEASE; NONHUMAN; PORTHIDIUM NASUTUM; PORTHIDIUM OPHRYOMEGAS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SNAKE; VIRUS NEUTRALIZATION; WESTERN BLOTTING;

ANIMALS; ANTIVENINS; CHROMATOGRAPHY, AFFINITY; CROTALID VENOMS; DRUG EVALUATION, PRECLINICAL; HEMORRHAGE; HORSES; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; LONGEVITY; MICE; MUSCLE, SKELETAL; MUSCULAR DISEASES; NEUTRALIZATION TESTS; PHOSPHOLIPASES A2; PROTEOMICS; SNAKE BITES; VIPERIDAE;

EID: 84873816276     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.12.024     Document Type: Article

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