Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom

Toxicon

Volumn 35, Issue 1, 1997, Pages 81-90

  Angulo, Yamileth ^a   Estrada, Ricardo ^a   Gutiérrez, José Maria ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ABSCESS; ANIMAL EXPERIMENT; ARTICLE; EDEMA; FIBROSIS; FISTULA; HEMATOCRIT; HEMOLYSIS; HORSE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODY FORMATION; ANTIVENINS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BLOOD COAGULATION TESTS; CROTALID VENOMS; HORSES; IMMUNIZATION; SNAKE BITES;

EID: 0031023402     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(96)00077-3     Document Type: Article

References (30)

1. Arroyo, O., Bolaños, R. and Muñoz, G. (1980) The bacterial flora of venom and mouth cavities of Costa Rican snakes. Bull. Pan Am. Hlth Org. 14, 280-285.
2. Blood, D. C., Henderson, J. A. and Radostits, O. M. (1979) Veterinary Medicine, p. 1135. Philadelphia: Lea and Febiger.
3. Bogarin, G., Segura, E., Durȧn, G., Lomonte, B., Rojas, G. and Gutiérrez, J. M. (1995) Evaluatión de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica. Toxicon 33, 1242-1245.
4. Bolaños, R. (1982) Las serpientes venenosas de Centroamérica y el problema del ofidismo. Primera parte. Aspectos zoológicos, epidemiológicos y biomédicos. Revta cost. Cienc. méd. 3, 165-184.
5. Bolaños, R. and Cerdas, L. (1980) Producción y control de sueros antiofídicos en Costa Rica. Bol. Of. sanit. pan-am. 88, 189-196.
6. Cardoso, J. L. C., Fan, H. W., Franca, F. O. S., Jorge, M. T., Leite, R. P., Nishioka, S. A., Avila, A., Sano-Martins, I. S., Tomy, S. C., Santoro, M. L., Chudzinski, A. M., Castro, S. C. B., Kamiguti, A. S., Kelen, E. M. A., Hirata, M. H., Mirandola, R. M. S., Theakston, R. D. G. and Warrell, D. A. (1993) Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in Sao Paulo. Q. J. Med. 86, 315-325.
7. Chromy, V., Fisher, J. and Kulhónek, V. (1974) Re-evaluation of EDTA-chelated Biuret reagent. Clin. Chem. 20, 1362-1363.
8. 2 en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica. Revta Biol. trop. 37, 187-191.
9. Estrada, R., Chaves, F., Robles, A., Rojas, E., Segura, E. and Gutiérrez, J. M. (1992) Valores hematológicos y de enzimas séricas en caballos inoculados con venenos de serpientes para la producción de antivenenos en Costa Rica. Revta Biol. trop. 40, 95-99.
10. Folin, O. (1974) On the determination of creatinine and creatine in blood, milk and tissues. J. biol. Chem. 17, 475.
11. Gené, J. A., Roy, A., Rojas, G., Gutiérrez, J. M. and Cerdas, L. (1989) Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom. Toxicon 27, 841-848.
12. Gutiérrez, J. M. (1995) Clinical toxicology of snake bite in Central America. In: Clinical Toxicology of Animal Venoms and Poisons, pp. 645-665 (Meier, J. and White, J., Eds). Boca Raton, FL: CRC Press.
13. Gutiérrez, J. M. and Lomonte, B. (1989) Local tissue damage induced by Bothrops snake venoms. A review. Mem. Inst. Butantan 51, 211-223.
14. Gutiérrez, J. M., Gené, J. A., Rojas, G. and Cerdas, L. (1985) Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom. Toxicon 23, 887-893.
15. Gutiérrez, J. M., Rojas, G., Lomonte, B., Gené, J. A. and Cerdas, L. (1986) Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom. Comp. Biochem. Physiol. 85C, 171-175.
16. Gutiérrez, J. M., Rojas, G. and Cerdas, L. (1987) Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster. Toxicon 25, 713-720.
17. Gutiérrez, J. M., Avila, C., Rojas, E. and Cerdas, L. (1988a) An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica. Toxicon 26, 411-413.
18. Gutiérrez, J. M., Chaves, F., Rojas, E., Elizondo, J., Avila, C. and Cerdas, L. (1988b) Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability. Revta Biol. trop. 36, 511-517.
19. Hati, R. N., Mandal, M. and Hati, A. K. (1990) Active immunization of rabbit with gamma irradiated Russell's viper venom toxoid. Toxicon 28, 895-902.
20. Higashi, H. G., Guidolin, R., Nishikawa, A. K., Yamaguchi, I. K., Lima, M. L. S. R., Morais, J. F. and Dias da Silva, W. (1989) Venenos botrópicos pré-tratados com inibidores ativos para os sitios enzimáticos de proteases e com substancia quelante preservam seu poder imunogénico. Mem. Inst. Butantan 51, 107-115.
21. Otero, R., Tobón, G. S., Gómez, L. F., Osorio, R., Valderrama, R., Hoyos, D., Urreta, J. E., Molina, S. and Arboleda, J. J. (1992) Accidente ofidico en Antioquia y Chocó. Aspectos clínicos y epidemiológicos (marzo de 1989-febrero de 1990). Acta méd. colomb. 17, 229-249.
22. Ouyang, C., Teng, C. M. and Huang, T. F. (1992) Characterization of snake venom components acting on blood coagulation and platelet function. Toxicon 30, 945-966.
23. Ownby, C. L. (1982) Pathology of rattlesnake envenomation. In: Rattlesnake Venoms, Their Actions and Treatment, pp. 163-209 (Tu, AT., Ed.). New York: Marcel Dekker.
24. Ravel, R. (1995) Clinical Laboratory Medicine, p. 724. St Louis: Mosby.
25. Rojas, G., Gutiérrez, J. M., Gené, J. A., Gómez, M. and Cerdas, L. (1987) Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica. Revta Biol. trop. 35, 59-67.
26. Russell, F. E. (1983) Snake Venom Poisoning, p. 562. New York: Scholium International.
27. Sáenz, G. F., Barrantes, A. and Chaves, M. (1987) Hematología Analitica. Teoría, Técnicas e Interpretaciones. San José: Editorial Universidad de Costa Rica.
28. Schosínsky, K., Vargas, M., Vinocour, E., González, O. M., Brilla, E. and Gutiérrez, A. (1983) Química Clínica. Manual de Técnicas de Laboratorio, 7th Edn, p. 224. San José: Universidad de Costa Rica.
29. Warrell, D. A. (1993) Venomous bites and stings in the tropical world. Med. J. Aust. 159, 773-779.
30. Wybenga, D. R., Gorgio, J. and Fileggi, V. J. (1971) Manual and automated methods for urea nitrogen measurement in whole serum. Clin. Chem. 17, 891-895.