메뉴 건너뛰기




Volumn 7, Issue 10, 2008, Pages 4396-4408

Snake venomics of the lesser antillean pit vipers bothrops caribbaeus and Bothrops lanceolatus: Correlation with toxicological activities and immunoreactivity of a heterologous antivenom

Author keywords

Bothrops caribbaeus; Bothrops lanceolatus; saint lucia lancehead viper; Fer de lance pitviper; Immunodepletion; Mass spectrometry; N terminal sequencing; Polyvalent (crotalinae) antivenom; Proteomics; Snake venom protein families; Snake venomics; Viperid toxins

Indexed keywords

AMINO ACID OXIDASE; LECTIN; METALLOPROTEINASE; PHOSPHOLIPASE A2; SERINE PROTEINASE; SNAKE VENOM; VENOM ANTISERUM; PEPTIDE; PROTEOME;

EID: 55949105234     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr8003826     Document Type: Article
Times cited : (111)

References (74)
  • 2
    • 33745617121 scopus 로고    scopus 로고
    • Confronting the neglected problem of snake bite envenoming: The need for a global partnership
    • Gutiérrez, J. M.; Theakston, R. D.; Warrell, D. A. Confronting the neglected problem of snake bite envenoming: the need for a global partnership. PLoS Med. 2006, 3, el50-159.
    • (2006) PLoS Med , vol.3
    • Gutiérrez, J.M.1    Theakston, R.D.2    Warrell, D.A.3
  • 3
    • 24944575056 scopus 로고    scopus 로고
    • Origin and phylogenetic position of the Lesser Antillean species of Bothrops (Serpentes, Viperidae): Biogeographical and medical implications
    • Wüster, W.; Thorpe, R. S.; Salomao, M. G.; Thomas, L.; Puorto, G; Theakston, R. D. G.; Warrell, D. A. Origin and phylogenetic position of the Lesser Antillean species of Bothrops (Serpentes, Viperidae): biogeographical and medical implications. Bull. Nat. Hist. Mus. Land (Zool.) 2002, 68, 101-106.
    • (2002) Bull. Nat. Hist. Mus. Land (Zool.) , vol.68 , pp. 101-106
    • Wüster, W.1    Thorpe, R.S.2    Salomao, M.G.3    Thomas, L.4    Puorto, G.5    Theakston, R.D.G.6    Warrell, D.A.7
  • 4
    • 0029035079 scopus 로고
    • The Research Group of Snakebites in Martinique Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: Failure of anticoagulants and efficacy of a monospecific antivenom
    • Thomas, L.; Tyburn, B.; Bucher, B.; Pecout, F.; Ketterle, J.; Rieux, D.; Smadja, D.; Gamier, D.; Plumelle, Y. The Research Group of Snakebites in Martinique Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom. Am. J. Trop. Med. Hyg. 1995, 52, 419-426.
    • (1995) Am. J. Trop. Med. Hyg , vol.52 , pp. 419-426
    • Thomas, L.1    Tyburn, B.2    Bucher, B.3    Pecout, F.4    Ketterle, J.5    Rieux, D.6    Smadja, D.7    Gamier, D.8    Plumelle, Y.9
  • 5
    • 61849176513 scopus 로고    scopus 로고
    • Thomas, L.; Tyburn, B. The Research Group of Snake Bite in Martinique. Bothrops lanceolatus bites in Martinique: Clinical aspects and treatment. In Envenomings and Their Treatments; Bon, C, Goyffon, M., Eds.; Fondation Marcel Mérieux: Lyon, France, 1996; pp 255-265.
    • Thomas, L.; Tyburn, B. The Research Group of Snake Bite in Martinique. Bothrops lanceolatus bites in Martinique: Clinical aspects and treatment. In Envenomings and Their Treatments; Bon, C, Goyffon, M., Eds.; Fondation Marcel Mérieux: Lyon, France, 1996; pp 255-265.
  • 6
    • 61849127311 scopus 로고    scopus 로고
    • Warrell, D. A. Snakebites in Central and South America: Epidemiology, clinical features and clinical management. In The Venomous Reptiles of the Western Hemisphere, Campbell, J. A., Lamar, W. W., Eds.; Comstock Publishing Associates: Ithaca, NY, 2004; pp 709-761.
    • Warrell, D. A. Snakebites in Central and South America: Epidemiology, clinical features and clinical management. In The Venomous Reptiles of the Western Hemisphere, Campbell, J. A., Lamar, W. W., Eds.; Comstock Publishing Associates: Ithaca, NY, 2004; pp 709-761.
  • 8
    • 0035189305 scopus 로고    scopus 로고
    • Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom
    • de Faria, L.; Antunes, E.; Bon, C; Lobo de Araújo, A. Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom. Toxicon 2001, 39, 825-830.
    • (2001) Toxicon , vol.39 , pp. 825-830
    • de Faria, L.1    Antunes, E.2    Bon, C.3    Lobo de Araújo, A.4
  • 9
    • 0037211943 scopus 로고    scopus 로고
    • Arruda, V. A.; Guimaraes, A. Q.; Hyslop, S.; d Araújo, P. M.; Bon, C; Lobo de Araújo, A. Bothrops lanceolatus (Fer de lance) venom stimulates leukocyte migration into the peritoneal cavity of mice. Toxicon 2003, 41, 99-107.
    • Arruda, V. A.; Guimaraes, A. Q.; Hyslop, S.; d Araújo, P. M.; Bon, C; Lobo de Araújo, A. Bothrops lanceolatus (Fer de lance) venom stimulates leukocyte migration into the peritoneal cavity of mice. Toxicon 2003, 41, 99-107.
  • 10
    • 3242769075 scopus 로고    scopus 로고
    • Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema
    • Guimaraes, A. Q.; Cruz-Hoffling, M. A.; Ferreira de Araújo, P. M.; Bon, C; Lobo de Araújo, A. Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema. Inflamm. Res. 2004, 53, 284-291.
    • (2004) Inflamm. Res , vol.53 , pp. 284-291
    • Guimaraes, A.Q.1    Cruz-Hoffling, M.A.2    Ferreira de Araújo, P.M.3    Bon, C.4    Lobo de Araújo, A.5
  • 11
    • 0033023294 scopus 로고    scopus 로고
    • Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothrops snake venoms
    • Bogarín, G.; Romero, M.; Rojas, G.; Lutsch, C; Casadamont, M.; Lang, J.; Otero, R; Gutiérrez, J. M. Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothrops snake venoms. Toxicon 1999, 37, 551-557.
    • (1999) Toxicon , vol.37 , pp. 551-557
    • Bogarín, G.1    Romero, M.2    Rojas, G.3    Lutsch, C.4    Casadamont, M.5    Lang, J.6    Otero, R.7    Gutiérrez, J.M.8
  • 14
    • 12644259526 scopus 로고    scopus 로고
    • Bucher, B.; Canonge, D.; Thomas, L.; Tyburn, B.; Robbe-Vincent, A.; Choumet, V.; Bon, C; Ketterlé, J.; Lang, J. Research Group of Snake Bites in Martinique. Clinical indicators of envenoming and serum levels of venom antigens in patients bitten by Bothrops lanceolatus in Martinique. Trans. R. Soc. Trop. Med. Hyg. 1997, 97, 186-190.
    • Bucher, B.; Canonge, D.; Thomas, L.; Tyburn, B.; Robbe-Vincent, A.; Choumet, V.; Bon, C; Ketterlé, J.; Lang, J. Research Group of Snake Bites in Martinique. Clinical indicators of envenoming and serum levels of venom antigens in patients bitten by Bothrops lanceolatus in Martinique. Trans. R. Soc. Trop. Med. Hyg. 1997, 97, 186-190.
  • 15
    • 36148976495 scopus 로고    scopus 로고
    • Calvete, J. J.; Juárez, P.; Sanz, L. Snake venomics. Strategy and applications. J. Mass Spectrom. 2007, 42, 1405-1414.
    • Calvete, J. J.; Juárez, P.; Sanz, L. Snake venomics. Strategy and applications. J. Mass Spectrom. 2007, 42, 1405-1414.
  • 16
    • 39749157183 scopus 로고    scopus 로고
    • Snake venomics of Central American pitvipers: Clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi
    • Angulo, Y.; Escolano, J.; Lomonte, B.; Gutiérrez, J. M.; Sanz, L.; Calvete, J. J. Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi. J. Proteome Res. 2008, 7, 708-719.
    • (2008) J. Proteome Res , vol.7 , pp. 708-719
    • Angulo, Y.1    Escolano, J.2    Lomonte, B.3    Gutiérrez, J.M.4    Sanz, L.5    Calvete, J.J.6
  • 17
    • 46449103484 scopus 로고    scopus 로고
    • Lomonte, B.; Escolano, J; Fernández, J.; Sanz, L.; Angulo, Y.; Gutiérrez, J. M.; Calvete, J. J. Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii. J. Proteome Res. 2008, 7, 2445-2457.
    • Lomonte, B.; Escolano, J; Fernández, J.; Sanz, L.; Angulo, Y.; Gutiérrez, J. M.; Calvete, J. J. Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii. J. Proteome Res. 2008, 7, 2445-2457.
  • 18
    • 0031023402 scopus 로고    scopus 로고
    • Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom
    • Angulo, Y.; Estrada, R.; Gutiérrez, J. M. Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon 1997, 35, 81-90.
    • (1997) Toxicon , vol.35 , pp. 81-90
    • Angulo, Y.1    Estrada, R.2    Gutiérrez, J.M.3
  • 19
    • 0028295746 scopus 로고
    • Caprylic acid fractionation of hyperimmune horse plasma: Description of a simple procedure for antivenom production
    • Rojas, G.; Jiménez, J. M.; Gutiérrez, J. M. Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production. Toxicon 1994, 32, 59-67.
    • (1994) Toxicon , vol.32 , pp. 59-67
    • Rojas, G.1    Jiménez, J.M.2    Gutiérrez, J.M.3
  • 21
    • 0037709383 scopus 로고    scopus 로고
    • Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity pro-teomics applications
    • Le Blanc, J. C.; Hager, J. W.; Ilisiu, A. M.; Hunter, C.; Zhong, F.; Chu, I. Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity pro-teomics applications. Proteomics 2003, 3, 859-869.
    • (2003) Proteomics , vol.3 , pp. 859-869
    • Le Blanc, J.C.1    Hager, J.W.2    Ilisiu, A.M.3    Hunter, C.4    Zhong, F.5    Chu, I.6
  • 22
    • 1242316947 scopus 로고    scopus 로고
    • Snake venomics: Characterization of protein families in Sistrurus barbouri venom by cysteine mapping, N-terminal sequencing, and tandem mass spectrometry analysis
    • Juárez, P.; Sanz, L.; Calvete, J. J. Snake venomics: characterization of protein families in Sistrurus barbouri venom by cysteine mapping, N-terminal sequencing, and tandem mass spectrometry analysis. Proteomics 2004, 4, 327-338.
    • (2004) Proteomics , vol.4 , pp. 327-338
    • Juárez, P.1    Sanz, L.2    Calvete, J.J.3
  • 23
    • 33745600373 scopus 로고    scopus 로고
    • Juárez, P.; Wagstaff, S. C; Oliver, J.; Sanz, L.; Harrison, R. A.; Calvete, J. J. Molecular cloning of disintegrin-like transcript BA-5A from Bitis arietans venom gland cDNA library: a putative intermediate in the evolution of the long chain disintegrin bit-istatin. J. Mol. Evol. 2006, 63, 142-152.
    • Juárez, P.; Wagstaff, S. C; Oliver, J.; Sanz, L.; Harrison, R. A.; Calvete, J. J. Molecular cloning of disintegrin-like transcript BA-5A from Bitis arietans venom gland cDNA library: a putative intermediate in the evolution of the long chain disintegrin bit-istatin. J. Mol. Evol. 2006, 63, 142-152.
  • 24
    • 27744533208 scopus 로고    scopus 로고
    • Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina
    • Bazaa, A.; Marrakchi, N.; El Ayeb, M.; Sanz, L.; Calvete, J. J. Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina. Proteomics 2005, 5, 4223-4235.
    • (2005) Proteomics , vol.5 , pp. 4223-4235
    • Bazaa, A.1    Marrakchi, N.2    El Ayeb, M.3    Sanz, L.4    Calvete, J.J.5
  • 25
    • 33748286744 scopus 로고    scopus 로고
    • Venom proteomes of closely-related Sistrurus rattlesnakes with divergent diets
    • Sanz, L.; Gibbs, H. L.; Mackessy, S. P.; Calvete, J. J. Venom proteomes of closely-related Sistrurus rattlesnakes with divergent diets. J. Proteome Res. 2006, 5, 2098-2112.
    • (2006) J. Proteome Res , vol.5 , pp. 2098-2112
    • Sanz, L.1    Gibbs, H.L.2    Mackessy, S.P.3    Calvete, J.J.4
  • 26
    • 34547144755 scopus 로고    scopus 로고
    • Snake venomics of Bitis species reveals large intragenus venom toxin composition variation: Application to taxonomy of congeneric taxa
    • Calvete, J. J.; Escolano, J.; Sanz, L. Snake venomics of Bitis species reveals large intragenus venom toxin composition variation: application to taxonomy of congeneric taxa. J. Proteome Res. 2007, 6, 2732-2745.
    • (2007) J. Proteome Res , vol.6 , pp. 2732-2745
    • Calvete, J.J.1    Escolano, J.2    Sanz, L.3
  • 27
    • 33846625097 scopus 로고    scopus 로고
    • Calvete, J. J.; Marcinkiewicz, C; Sanz, L. Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2. J. Proteome Res. 2007, 6, 326-336.
    • Calvete, J. J.; Marcinkiewicz, C; Sanz, L. Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2. J. Proteome Res. 2007, 6, 326-336.
  • 28
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H.; Staehelin, T.; Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 1979, 76, 4350-4354.
    • (1979) Proc. Natl. Acad. Sci. U.S.A , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 29
    • 0022354215 scopus 로고
    • Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom
    • Gutiérrez, J. M.; Gené, J. A.; Rojas, G.; Cerdas, L. Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom. Toxicon 1985, 23, 887-893.
    • (1985) Toxicon , vol.23 , pp. 887-893
    • Gutiérrez, J.M.1    Gené, J.A.2    Rojas, G.3    Cerdas, L.4
  • 30
    • 0027534529 scopus 로고
    • Å Host response to Bothrops asper snake venom: Analysis of edema formation, inflammatory cells and cytokine release in a mouse model
    • Lomonte, B.; Tarkowski, A.; Hanson, L. Å Host response to Bothrops asper snake venom: Analysis of edema formation, inflammatory cells and cytokine release in a mouse model. Inflammation 1993, 17, 93-105.
    • (1993) Inflammation , vol.1 , Issue.7 , pp. 93-105
    • Lomonte, B.1    Tarkowski, A.2    Hanson, L.3
  • 31
    • 10044228408 scopus 로고    scopus 로고
    • Neutralization of four Peruvian Bothrops sp snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: Preclinical assessment
    • Rojas, E.; Quesada, L.; Arce, V.; Lomonte, B.; Rojas, G.; Gutiérrez, J. M. Neutralization of four Peruvian Bothrops sp snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment. Acta Trop. 2005, 93, 85-95.
    • (2005) Acta Trop , vol.93 , pp. 85-95
    • Rojas, E.1    Quesada, L.2    Arce, V.3    Lomonte, B.4    Rojas, G.5    Gutiérrez, J.M.6
  • 32
    • 36949089946 scopus 로고
    • Disk electrophoresis of basic proteins and peptides on polyacrylamide gels
    • Reislfeld, R. A.; Lewis, U. J.; Williams, D. E. Disk electrophoresis of basic proteins and peptides on polyacrylamide gels. Nature 1962, 195, 281-283.
    • (1962) Nature , vol.195 , pp. 281-283
    • Reislfeld, R.A.1    Lewis, U.J.2    Williams, D.E.3
  • 33
    • 0026724529 scopus 로고
    • Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops asper
    • Lomonte, B.; Carmona, E. Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops asper. Comp. Biochem. Physiol., Part B 1992, 102, 325-329.
    • (1992) Comp. Biochem. Physiol., Part B , vol.102 , pp. 325-329
    • Lomonte, B.1    Carmona, E.2
  • 34
    • 0021061641 scopus 로고
    • Development of simple standard assay procedures for the characterization of snake venoms
    • Theakston, R. D. G.; Reid, H. A. Development of simple standard assay procedures for the characterization of snake venoms. Bull. World Health Org. 1983, 61, 949-956.
    • (1983) Bull. World Health Org , vol.61 , pp. 949-956
    • Theakston, R.D.G.1    Reid, H.A.2
  • 35
    • 0024372242 scopus 로고
    • Comparative study on the coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom
    • Gené, J. A.; Roy, A.; Rojas, G.; Gutiérrez, J. M.; Cerdas, L. Comparative study on the coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom. Toxicon 1989, 27, 841-848.
    • (1989) Toxicon , vol.27 , pp. 841-848
    • Gené, J.A.1    Roy, A.2    Rojas, G.3    Gutiérrez, J.M.4    Cerdas, L.5
  • 36
    • 22144451490 scopus 로고    scopus 로고
    • Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage
    • Rucavado, A.; Soto, M.; Escalante, T.; Loría, G. D.; Ami, R. K.; Gutiérrez, J. M. Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. Thromb. Haemost. 2005, 94, 123-131.
    • (2005) Thromb. Haemost , vol.94 , pp. 123-131
    • Rucavado, A.1    Soto, M.2    Escalante, T.3    Loría, G.D.4    Ami, R.K.5    Gutiérrez, J.M.6
  • 37
    • 0023516712 scopus 로고
    • 2 activity by a colorimetric assay using a pH indicator
    • 2 activity by a colorimetric assay using a pH indicator. Toxicon 1987, 25, 1181-1188.
    • (1987) Toxicon , vol.25 , pp. 1181-1188
    • Lobo de Araújo, A.1    Radvanyi, F.2
  • 38
    • 4744363468 scopus 로고    scopus 로고
    • A novel P-I class metallo-proteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom
    • Wang, W. J.; Shih, C. H.; Huang, T. F. A novel P-I class metallo-proteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom. Biochem. Biophys. Res. Commun. 2004, 324, 224-230.
    • (2004) Biochem. Biophys. Res. Commun , vol.324 , pp. 224-230
    • Wang, W.J.1    Shih, C.H.2    Huang, T.F.3
  • 39
    • 0025048405 scopus 로고    scopus 로고
    • bGutiérrez, J. M.; Rojas, G.; Lomonte, B.; Gené, J. A.; Chaves, F.; Alvarado, J.; Rojas, E. Standardization of assays for testing the neutralizing ability of antivenoms. Toxicon 1990, 28, 1127-1129.
    • (39)bGutiérrez, J. M.; Rojas, G.; Lomonte, B.; Gené, J. A.; Chaves, F.; Alvarado, J.; Rojas, E. Standardization of assays for testing the neutralizing ability of antivenoms. Toxicon 1990, 28, 1127-1129.
  • 40
    • 0038696349 scopus 로고    scopus 로고
    • Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes
    • Arce, V.; Rojas, E.; Ownby, C. L.; Rojas, G.; Gutiérrez, J. M. Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes. Toxicon 2003, 41, 851-860.
    • (2003) Toxicon , vol.41 , pp. 851-860
    • Arce, V.1    Rojas, E.2    Ownby, C.L.3    Rojas, G.4    Gutiérrez, J.M.5
  • 41
    • 13944263624 scopus 로고    scopus 로고
    • Stroka, A.; Donato, J. L.; Bon, C; Hyslop, S.; Lobo de Araújo, A. Purification and characterization of a hemorrhagic metallopro-teinase from Bothrops lanceolatus (Fer-de-lance) snake venom. Toxicon 2005, 45, 411-420.
    • Stroka, A.; Donato, J. L.; Bon, C; Hyslop, S.; Lobo de Araújo, A. Purification and characterization of a hemorrhagic metallopro-teinase from Bothrops lanceolatus (Fer-de-lance) snake venom. Toxicon 2005, 45, 411-420.
  • 42
    • 0345726054 scopus 로고    scopus 로고
    • Purification from Bothrops lanceolatus (Fer de lance) venom of a fibrino(geno)lytic enzyme with esterolytic activity
    • Lobo de Araújo, A.; Donato, J. L.; Bon, C. Purification from Bothrops lanceolatus (Fer de lance) venom of a fibrino(geno)lytic enzyme with esterolytic activity. Toxicon 1998, 36, 745-758.
    • (1998) Toxicon , vol.36 , pp. 745-758
    • Lobo de Araújo, A.1    Donato, J.L.2    Bon, C.3
  • 43
    • 0027933653 scopus 로고
    • 2 from Bothrops lanceolatus (Fer de lance) venom: Molecular and enzymatic properties
    • 2 from Bothrops lanceolatus (Fer de lance) venom: molecular and enzymatic properties. Toxicon 1994, 32, 1069-1081.
    • (1994) Toxicon , vol.32 , pp. 1069-1081
    • Lobo de Araújo, A.L.1    Radvanyi, F.2    Bon, C.3
  • 45
    • 9744281932 scopus 로고    scopus 로고
    • Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom
    • Ogawa, T.; Chijiwa, T.; Oda-Ueda, N.; Ohno, M. Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom. Toxicon 2005, 45, 1-14.
    • (2005) Toxicon , vol.45 , pp. 1-14
    • Ogawa, T.1    Chijiwa, T.2    Oda-Ueda, N.3    Ohno, M.4
  • 49
    • 14844287849 scopus 로고    scopus 로고
    • Ménez, A, Ed, John Wiley & Sons, Ltd, Chichester, U.K
    • Perspectives in Molecular Toxinology. Ménez, A., Ed.; John Wiley & Sons, Ltd.: Chichester, U.K., 2002.
    • (2002) Perspectives in Molecular Toxinology
  • 51
    • 0141783547 scopus 로고    scopus 로고
    • Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia
    • Saldarriaga, M. M.; Otero, R.; Núñez, V.; Toro, M. F.; Díaz, A.; Gutiérrez, J. M. Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia. Toxicon 2003, 42, 405-411.
    • (2003) Toxicon , vol.42 , pp. 405-411
    • Saldarriaga, M.M.1    Otero, R.2    Núñez, V.3    Toro, M.F.4    Díaz, A.5    Gutiérrez, J.M.6
  • 52
    • 0028972997 scopus 로고
    • 2 myotoxins from Bothrops snake venoms
    • 2 myotoxins from Bothrops snake venoms. Toxicon 1995, 33, 1405-1424.
    • (1995) Toxicon , vol.33 , pp. 1405-1424
    • Gutiérrez, J.M.1    Lomonte, B.2
  • 53
    • 19544382337 scopus 로고    scopus 로고
    • Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases
    • Fox, J. W.; Serrano, S. M. T. Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 2005, 45, 969-985.
    • (2005) Toxicon , vol.45 , pp. 969-985
    • Fox, J.W.1    Serrano, S.M.T.2
  • 54
    • 19544381172 scopus 로고    scopus 로고
    • Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage
    • Gutiérrez, J. M.; Rucavado, A.; Escalante, T.; Díaz, C. Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. Toxicon 2005, 45, 997-1011.
    • (2005) Toxicon , vol.45 , pp. 997-1011
    • Gutiérrez, J.M.1    Rucavado, A.2    Escalante, T.3    Díaz, C.4
  • 55
    • 0017258208 scopus 로고
    • The thrombin-like enzyme from Bothrops atrox snake venom. Properties of the enzyme purified by affinity chromatography on p-aminobenzamidine-substituted agarose
    • Holleman, W. H.; Weiss, L. J. The thrombin-like enzyme from Bothrops atrox snake venom. Properties of the enzyme purified by affinity chromatography on p-aminobenzamidine-substituted agarose. J. Biol. Chem. 1976, 251, 1663-1669.
    • (1976) J. Biol. Chem , vol.251 , pp. 1663-1669
    • Holleman, W.H.1    Weiss, L.J.2
  • 56
    • 0344425491 scopus 로고
    • Characterization of thrombin-like proteinase from Bothrops asper venom
    • Rosenberg, P, Ed, Pergamon Press: Oxford
    • Aragón, F.; Gubensek, F. Characterization of thrombin-like proteinase from Bothrops asper venom. In Toxins: Animal, Plant and Microbial; Rosenberg, P., Ed.; Pergamon Press: Oxford, 1978, 107-111.
    • (1978) Toxins: Animal, Plant and Microbial , pp. 107-111
    • Aragón, F.1    Gubensek, F.2
  • 58
    • 85128520935 scopus 로고    scopus 로고
    • Pérez, A. V.; Rucavado, A.; Sanz, L.; Calvete, J. J.; Gutiérrez, J. M. Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper. Braz. J. Med. Biol. Res. 2008, 41, 12-17.
    • Pérez, A. V.; Rucavado, A.; Sanz, L.; Calvete, J. J.; Gutiérrez, J. M. Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper. Braz. J. Med. Biol. Res. 2008, 41, 12-17.
  • 59
    • 0023149383 scopus 로고
    • Blood coagulation induced by the venom of Bothrops atrox. 1. Identification, purification and properties of a prothrombin activator
    • Hofmann, H.; Bon, C. Blood coagulation induced by the venom of Bothrops atrox. 1. Identification, purification and properties of a prothrombin activator. Biochemistry 1987, 26, 772-780.
    • (1987) Biochemistry , vol.26 , pp. 772-780
    • Hofmann, H.1    Bon, C.2
  • 60
    • 0023123390 scopus 로고
    • Blood coagulation induced by the venom of Bothrops atrox. 2. Identification, purification and properties of two factor X activators
    • Hofmann, H.; Bon, C. Blood coagulation induced by the venom of Bothrops atrox. 2. Identification, purification and properties of two factor X activators. Biochemistry 1987, 26, 780-787.
    • (1987) Biochemistry , vol.26 , pp. 780-787
    • Hofmann, H.1    Bon, C.2
  • 61
    • 0141790425 scopus 로고    scopus 로고
    • Characterization of 'basparin A', a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis
    • Loría, G. D.; Rucavado, A.; Kamiguti, A. S.; Theakston, R. D. G.; Fox, J.; Alape, A.; Gutiérrez, J. M. Characterization of 'basparin A', a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis. Arch. Biochem. Biophys. 2003, 418, 13-24.
    • (2003) Arch. Biochem. Biophys , vol.418 , pp. 13-24
    • Loría, G.D.1    Rucavado, A.2    Kamiguti, A.S.3    Theakston, R.D.G.4    Fox, J.5    Alape, A.6    Gutiérrez, J.M.7
  • 63
    • 0036342060 scopus 로고    scopus 로고
    • A new insular species of pitviper from Brazil, with comments on evolutionary biology and conservation of the Bothrops jararaca group (Serpentes, Viperidae)
    • Marques, O. A. V.; Martins, M.; Sazima, I. A new insular species of pitviper from Brazil, with comments on evolutionary biology and conservation of the Bothrops jararaca group (Serpentes, Viperidae). Herpetologica 2002, 58, 303-312.
    • (2002) Herpetologica , vol.58 , pp. 303-312
    • Marques, O.A.V.1    Martins, M.2    Sazima, I.3
  • 64
    • 25144463011 scopus 로고    scopus 로고
    • Biological and immunological properties of the venom of Bothrops alcatraz, an endemic species of pitviper from Brazil
    • Furtado, M. F. D. Biological and immunological properties of the venom of Bothrops alcatraz, an endemic species of pitviper from Brazil. Comp. Biochem. Physiol C, 2005, 141, 117-123.
    • (2005) Comp. Biochem. Physiol C , Issue.141 , pp. 117-123
    • Furtado, M.F.D.1
  • 65
    • 33750206772 scopus 로고    scopus 로고
    • Phylogeography of the Bothrops jararaca complex (Serpentes: Viperidae): past fragmentation and island colonization in the Brazilian Atlantic forest
    • Grazziotin, F. G.; Monzel, M.; Echeverrigaray, S.; Bonatto, S. L. Phylogeography of the Bothrops jararaca complex (Serpentes: Viperidae): past fragmentation and island colonization in the Brazilian Atlantic forest. Mol. Ecol. 2006, 15, 3969-3982.
    • (2006) Mol. Ecol , vol.15 , pp. 3969-3982
    • Grazziotin, F.G.1    Monzel, M.2    Echeverrigaray, S.3    Bonatto, S.L.4
  • 66
    • 0019236371 scopus 로고
    • Estudio comparativo de venenos de ejemplares recién nacidos y adultos de Bothrops asper.
    • Gutiérrez, J. M.; Chaves, F.; Bolanos, R. Estudio comparativo de venenos de ejemplares recién nacidos y adultos de Bothrops asper. Rev. Biol. Trop. 1980, 28, 341-351.
    • (1980) Rev. Biol. Trop , vol.28 , pp. 341-351
    • Gutiérrez, J.M.1    Chaves, F.2    Bolanos, R.3
  • 67
    • 0026744091 scopus 로고
    • Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (terciopelo)
    • Chaves, F.; Gutiérrez, J. M.; Brenes, F. Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (terciopelo). Toxicon 1992, 30, 1099-1109.
    • (1992) Toxicon , vol.30 , pp. 1099-1109
    • Chaves, F.1    Gutiérrez, J.M.2    Brenes, F.3
  • 68
    • 0029949611 scopus 로고    scopus 로고
    • 1-integrin by the snake venom metafloproteinase jararhagin
    • 1-integrin by the snake venom metafloproteinase jararhagin. Biochem. J. 1996, 320, 635-641.
    • (1996) Biochem. J , vol.320 , pp. 635-641
    • Kamiguti, A.S.1    Hay, C.R.2    Zuzel, M.3
  • 70
    • 33746497351 scopus 로고    scopus 로고
    • Thrombotic stroke following snake bites by the 'Fer-de-lance' Bothrops lanceolatus in Martinique despite treatment: A report of three recent cases
    • Thomas, L.; Chausson, N.; Uzan, J.; Kaidomar, S.; Vignes, R.; Plumelle, Y.; Bucher, B.; Smadja, D. Thrombotic stroke following snake bites by the 'Fer-de-lance' Bothrops lanceolatus in Martinique despite treatment: a report of three recent cases. Toxicon 2006, 48, 23-28.
    • (2006) Toxicon , vol.48 , pp. 23-28
    • Thomas, L.1    Chausson, N.2    Uzan, J.3    Kaidomar, S.4    Vignes, R.5    Plumelle, Y.6    Bucher, B.7    Smadja, D.8
  • 71
    • 0029063285 scopus 로고
    • Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia)
    • Otero, R.; Nunez, V.; Osorio, R. G.; Gutierrez, J. M.; Giraldo, C. A.; Posada, L. E. Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia). Toxicon 1995, 33, 809-815.
    • (1995) Toxicon , vol.33 , pp. 809-815
    • Otero, R.1    Nunez, V.2    Osorio, R.G.3    Gutierrez, J.M.4    Giraldo, C.A.5    Posada, L.E.6
  • 72
    • 34247846161 scopus 로고    scopus 로고
    • Enzymatic and immunochemical characterization of Bothrops insularis venom and its neutralization by polyspecific Bothrops antivenom
    • Lira, M. S.; Furtado, M. F.; Martins, M. L.; Lopes-Ferreira, M.; Santoro, M. L.; Barbara, K. C. Enzymatic and immunochemical characterization of Bothrops insularis venom and its neutralization by polyspecific Bothrops antivenom. Toxicon 2007, 49, 982-994.
    • (2007) Toxicon , vol.49 , pp. 982-994
    • Lira, M.S.1    Furtado, M.F.2    Martins, M.L.3    Lopes-Ferreira, M.4    Santoro, M.L.5    Barbara, K.C.6
  • 73
    • 0037401660 scopus 로고    scopus 로고
    • Report of a WHO workshop on standardization and control of antivenoms
    • Theakston, R. D. G.; Warrell, D. A.; Griffiths, E. Report of a WHO workshop on standardization and control of antivenoms. Toxicon 2003, 41, 541-557.
    • (2003) Toxicon , vol.41 , pp. 541-557
    • Theakston, R.D.G.1    Warrell, D.A.2    Griffiths, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.