메뉴 건너뛰기




Volumn 14, Issue 2, 2013, Pages

Targeting developmental pathways in children with cancer: What price success?

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CETUXIMAB; CIXUTUMUMAB; CRIZOTINIB; DASATINIB; ERLOTINIB; EVEROLIMUS; IMATINIB; IMMUNOGLOBULIN; OLAPARIB; RAPAMYCIN; RITUXIMAB; SORAFENIB; SUNITINIB; VISMODEGIB;

EID: 84873809412     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(12)70530-2     Document Type: Review
Times cited : (31)

References (75)
  • 1
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein IB Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 2002, 297:63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 2
    • 84861850285 scopus 로고    scopus 로고
    • Very long-term follow-up results of imatinib mesylate therapy in chronic phase chronic myeloid leukemia after failure of interferon alpha therapy
    • Kantarjian H, O'Brien S, Garcia-Manero G, et al. Very long-term follow-up results of imatinib mesylate therapy in chronic phase chronic myeloid leukemia after failure of interferon alpha therapy. Cancer 2012, 118:3116-3122.
    • (2012) Cancer , vol.118 , pp. 3116-3122
    • Kantarjian, H.1    O'Brien, S.2    Garcia-Manero, G.3
  • 3
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study
    • Schultz KR, Bowman WP, Aledo A, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol 2009, 27:5175-5181.
    • (2009) J Clin Oncol , vol.27 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 4
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009, 136:823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 5
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005, 434:913-917.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 6
    • 84859391984 scopus 로고    scopus 로고
    • PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma
    • Brenner JC, Feng FY, Han S, et al. PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. Cancer Res 2012, 72:1608-1613.
    • (2012) Cancer Res , vol.72 , pp. 1608-1613
    • Brenner, J.C.1    Feng, F.Y.2    Han, S.3
  • 7
    • 84865145584 scopus 로고    scopus 로고
    • Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition
    • Casa-Selves M, Kim J, Zhang Y, et al. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res 2012, 72:4154-4164.
    • (2012) Cancer Res , vol.72 , pp. 4154-4164
    • Casa-Selves, M.1    Kim, J.2    Zhang, Y.3
  • 8
    • 84861999101 scopus 로고    scopus 로고
    • Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia
    • Porter CC, Kim J, Fosmire S, et al. Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia. Leukemia 2012, 26:1266-1276.
    • (2012) Leukemia , vol.26 , pp. 1266-1276
    • Porter, C.C.1    Kim, J.2    Fosmire, S.3
  • 9
    • 77954299059 scopus 로고    scopus 로고
    • Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
    • Gregory MA, Phang TL, Neviani P, et al. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell 2010, 18:74-87.
    • (2010) Cancer Cell , vol.18 , pp. 74-87
    • Gregory, M.A.1    Phang, T.L.2    Neviani, P.3
  • 10
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst AW, Bodemann BO, Cardenas J, et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007, 446:815-819.
    • (2007) Nature , vol.446 , pp. 815-819
    • Whitehurst, A.W.1    Bodemann, B.O.2    Cardenas, J.3
  • 11
    • 84860563856 scopus 로고    scopus 로고
    • Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature
    • Grunewald TG, Greulich N, Kontny U, et al. Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature. Klin Padiatr 2012, 224:124-131.
    • (2012) Klin Padiatr , vol.224 , pp. 124-131
    • Grunewald, T.G.1    Greulich, N.2    Kontny, U.3
  • 12
    • 67650496613 scopus 로고    scopus 로고
    • Developmental genes and cancer in children
    • Moore SW Developmental genes and cancer in children. Pediatr Blood Cancer 2009, 52:755-760.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 755-760
    • Moore, S.W.1
  • 13
    • 77951605788 scopus 로고    scopus 로고
    • The Hox genes and their roles in oncogenesis
    • Shah N, Sukumar S The Hox genes and their roles in oncogenesis. Nat Rev Cancer 2010, 10:361-371.
    • (2010) Nat Rev Cancer , vol.10 , pp. 361-371
    • Shah, N.1    Sukumar, S.2
  • 14
    • 42649090823 scopus 로고    scopus 로고
    • Grappling with the HOX network in hematopoiesis and leukemia
    • McGonigle GJ, Lappin TR, Thompson A Grappling with the HOX network in hematopoiesis and leukemia. Front Biosci 2008, 13:4297-4308.
    • (2008) Front Biosci , vol.13 , pp. 4297-4308
    • McGonigle, G.J.1    Lappin, T.R.2    Thompson, A.3
  • 15
    • 0031036694 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain PTCH mutations
    • Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997, 57:842-845.
    • (1997) Cancer Res , vol.57 , pp. 842-845
    • Raffel, C.1    Jenkins, R.B.2    Frederick, L.3
  • 16
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002, 31:306-310.
    • (2002) Nat Genet , vol.31 , pp. 306-310
    • Taylor, M.D.1    Liu, L.2    Raffel, C.3
  • 17
    • 79951904426 scopus 로고    scopus 로고
    • Clinical experience with Hedgehog pathway inhibitors
    • Low JA, de Sauvage FJ Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol 2010, 28:5321-5326.
    • (2010) J Clin Oncol , vol.28 , pp. 5321-5326
    • Low, J.A.1    de Sauvage, F.J.2
  • 18
    • 40149091426 scopus 로고    scopus 로고
    • Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    • Kimura H, Ng JM, Curran T Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 2008, 13:249-260.
    • (2008) Cancer Cell , vol.13 , pp. 249-260
    • Kimura, H.1    Ng, J.M.2    Curran, T.3
  • 19
    • 12144258439 scopus 로고    scopus 로고
    • The emerging normal and disease-related roles of anaplastic lymphoma kinase
    • Pulford K, Lamant L, Espinos E, et al. The emerging normal and disease-related roles of anaplastic lymphoma kinase. Cell Mol Life Sci 2004, 61:2939-2953.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2939-2953
    • Pulford, K.1    Lamant, L.2    Espinos, E.3
  • 20
    • 84863466512 scopus 로고    scopus 로고
    • Targeting ALK in neuroblastoma-preclinical and clinical advancements
    • Carpenter EL, Mosse YP Targeting ALK in neuroblastoma-preclinical and clinical advancements. Nat Rev Clin Oncol 2012, 9:391-399.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 391-399
    • Carpenter, E.L.1    Mosse, Y.P.2
  • 22
    • 33749599695 scopus 로고    scopus 로고
    • Chronic health conditions in adult survivors of childhood cancer
    • Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006, 355:1572-1582.
    • (2006) N Engl J Med , vol.355 , pp. 1572-1582
    • Oeffinger, K.C.1    Mertens, A.C.2    Sklar, C.A.3
  • 23
    • 84865165918 scopus 로고    scopus 로고
    • The price we pay for progress: a meta-analysis of harms of newly approved anticancer drugs
    • Niraula S, Seruga B, Ocana A, et al. The price we pay for progress: a meta-analysis of harms of newly approved anticancer drugs. J Clin Oncol 2012, 30:3012-3019.
    • (2012) J Clin Oncol , vol.30 , pp. 3012-3019
    • Niraula, S.1    Seruga, B.2    Ocana, A.3
  • 24
    • 67349083594 scopus 로고    scopus 로고
    • Skin toxicities associated with epidermal growth factor receptor inhibitors
    • Li T, Perez-Soler R Skin toxicities associated with epidermal growth factor receptor inhibitors. Target Oncol 2009, 4:107-119.
    • (2009) Target Oncol , vol.4 , pp. 107-119
    • Li, T.1    Perez-Soler, R.2
  • 25
    • 84862502742 scopus 로고    scopus 로고
    • Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension
    • Schuster C, Eikesdal HP, Puntervoll H, et al. Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLoS One 2012, 7:e38364.
    • (2012) PLoS One , vol.7
    • Schuster, C.1    Eikesdal, H.P.2    Puntervoll, H.3
  • 26
    • 34447129570 scopus 로고    scopus 로고
    • Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies
    • Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007, 13:3913-3921.
    • (2007) Clin Cancer Res , vol.13 , pp. 3913-3921
    • Wacker, B.1    Nagrani, T.2    Weinberg, J.3    Witt, K.4    Clark, G.5    Cagnoni, P.J.6
  • 27
    • 70350002279 scopus 로고    scopus 로고
    • Adverse effects of anticancer agents that target the VEGF pathway
    • Chen HX, Cleck JN Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009, 6:465-477.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 465-477
    • Chen, H.X.1    Cleck, J.N.2
  • 28
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
    • Yuen JS, Macaulay VM Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther Targets 2008, 12:589-603.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 589-603
    • Yuen, J.S.1    Macaulay, V.M.2
  • 29
    • 80052790433 scopus 로고    scopus 로고
    • Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia
    • Shima H, Tokuyama M, Tanizawa A, et al. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia. J Pediatr 2011, 159:676-681.
    • (2011) J Pediatr , vol.159 , pp. 676-681
    • Shima, H.1    Tokuyama, M.2    Tanizawa, A.3
  • 30
    • 84863865642 scopus 로고    scopus 로고
    • Imatinib has adverse effect on growth in children with chronic myeloid leukemia
    • Bansal D, Shava U, Varma N, Trehan A, Marwaha RK Imatinib has adverse effect on growth in children with chronic myeloid leukemia. Pediatr Blood Cancer 2012, 59:481-484.
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 481-484
    • Bansal, D.1    Shava, U.2    Varma, N.3    Trehan, A.4    Marwaha, R.K.5
  • 31
    • 70450277310 scopus 로고    scopus 로고
    • Imatinib mesylate causes growth plate closure in vivo
    • Vandyke K, Dewar AL, Fitter S, et al. Imatinib mesylate causes growth plate closure in vivo. Leukemia 2009, 23:2155-2159.
    • (2009) Leukemia , vol.23 , pp. 2155-2159
    • Vandyke, K.1    Dewar, A.L.2    Fitter, S.3
  • 32
    • 79551622697 scopus 로고    scopus 로고
    • Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy
    • Hobernicht SL, Schweiger B, Zeitler P, Wang M, Hunger SP Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy. Pediatr Blood Cancer 2011, 56:671-673.
    • (2011) Pediatr Blood Cancer , vol.56 , pp. 671-673
    • Hobernicht, S.L.1    Schweiger, B.2    Zeitler, P.3    Wang, M.4    Hunger, S.P.5
  • 33
    • 0023638627 scopus 로고
    • Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer
    • Byrne J, Mulvihill JJ, Myers MH, et al. Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 1987, 317:1315-1321.
    • (1987) N Engl J Med , vol.317 , pp. 1315-1321
    • Byrne, J.1    Mulvihill, J.J.2    Myers, M.H.3
  • 34
  • 35
    • 8344230641 scopus 로고    scopus 로고
    • Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome
    • Seshadri T, Seymour JF, McArthur GA Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. N Engl J Med 2004, 351:2134-2135.
    • (2004) N Engl J Med , vol.351 , pp. 2134-2135
    • Seshadri, T.1    Seymour, J.F.2    McArthur, G.A.3
  • 36
    • 79951952200 scopus 로고    scopus 로고
    • Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty
    • Mariani S, Basciani S, Fabbri A, et al. Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty. Fertil Steril 2011, 95:1120.
    • (2011) Fertil Steril , vol.95 , pp. 1120
    • Mariani, S.1    Basciani, S.2    Fabbri, A.3
  • 37
    • 84867864355 scopus 로고    scopus 로고
    • Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer
    • Weickhardt AJ, Rothman MS, Salian-Mehta S, et al. Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer 2012, 118:5302-5309.
    • (2012) Cancer , vol.118 , pp. 5302-5309
    • Weickhardt, A.J.1    Rothman, M.S.2    Salian-Mehta, S.3
  • 38
    • 67650173972 scopus 로고    scopus 로고
    • Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy
    • Torino F, Corsello SM, Longo R, Barnabei A, Gasparini G Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nat Rev Clin Oncol 2009, 6:219-228.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 219-228
    • Torino, F.1    Corsello, S.M.2    Longo, R.3    Barnabei, A.4    Gasparini, G.5
  • 39
    • 33644545382 scopus 로고    scopus 로고
    • Infection, immune responses and the aetiology of childhood leukaemia
    • Greaves M Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 2006, 6:193-203.
    • (2006) Nat Rev Cancer , vol.6 , pp. 193-203
    • Greaves, M.1
  • 40
    • 0029119251 scopus 로고
    • Immunodeficiency in long-term survivors of acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munster therapy
    • Smith S, Schiffman G, Karayalcin G, Bonagura V Immunodeficiency in long-term survivors of acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munster therapy. J Pediatr 1995, 127:68-75.
    • (1995) J Pediatr , vol.127 , pp. 68-75
    • Smith, S.1    Schiffman, G.2    Karayalcin, G.3    Bonagura, V.4
  • 41
    • 78049510428 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    • Krueger DA, Care MM, Holland K, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010, 363:1801-1811.
    • (2010) N Engl J Med , vol.363 , pp. 1801-1811
    • Krueger, D.A.1    Care, M.M.2    Holland, K.3
  • 42
    • 77950516104 scopus 로고    scopus 로고
    • MTOR signaling and drug development in cancer
    • Dancey J mTOR signaling and drug development in cancer. Nat Rev Clin Oncol 2010, 7:209-219.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 209-219
    • Dancey, J.1
  • 43
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002, 346:235-242.
    • (2002) N Engl J Med , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 44
    • 77955504706 scopus 로고    scopus 로고
    • Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia
    • Meinhardt A, Burkhardt B, Zimmermann M, et al. Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol 2010, 28:3115-3121.
    • (2010) J Clin Oncol , vol.28 , pp. 3115-3121
    • Meinhardt, A.1    Burkhardt, B.2    Zimmermann, M.3
  • 45
    • 33645983193 scopus 로고    scopus 로고
    • Dose-dense R-CHOP-14 supported by pegfilgrastim in patients with diffuse large B-cell lymphoma: a phase II study of feasibility and toxicity
    • Brusamolino E, Rusconi C, Montalbetti L, et al. Dose-dense R-CHOP-14 supported by pegfilgrastim in patients with diffuse large B-cell lymphoma: a phase II study of feasibility and toxicity. Haematologica 2006, 91:496-502.
    • (2006) Haematologica , vol.91 , pp. 496-502
    • Brusamolino, E.1    Rusconi, C.2    Montalbetti, L.3
  • 46
    • 77950917503 scopus 로고    scopus 로고
    • Severe hypogammaglobulinemia persisting for 6 years after treatment with rituximab combined chemotherapy due to arrest of B lymphocyte differentiation together with alteration of T lymphocyte homeostasis
    • Irie E, Shirota Y, Suzuki C, et al. Severe hypogammaglobulinemia persisting for 6 years after treatment with rituximab combined chemotherapy due to arrest of B lymphocyte differentiation together with alteration of T lymphocyte homeostasis. Int J Hematol 2010, 91:501-508.
    • (2010) Int J Hematol , vol.91 , pp. 501-508
    • Irie, E.1    Shirota, Y.2    Suzuki, C.3
  • 47
    • 42649121621 scopus 로고    scopus 로고
    • Profound hypogammaglobulinemia 7 years after treatment for indolent lymphoma
    • Walker AR, Kleiner A, Rich L, et al. Profound hypogammaglobulinemia 7 years after treatment for indolent lymphoma. Cancer Invest 2008, 26:431-433.
    • (2008) Cancer Invest , vol.26 , pp. 431-433
    • Walker, A.R.1    Kleiner, A.2    Rich, L.3
  • 48
    • 77957275541 scopus 로고    scopus 로고
    • Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature
    • Wolach O, Bairey O, Lahav M Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature. Medicine (Baltimore) 2010, 89:308-318.
    • (2010) Medicine (Baltimore) , vol.89 , pp. 308-318
    • Wolach, O.1    Bairey, O.2    Lahav, M.3
  • 49
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, White CA, et al. IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 1997, 90:2188-2195.
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 50
    • 0026522204 scopus 로고
    • Profound block in thymocyte development in mice lacking p56lck
    • Molina TJ, Kishihara K, Siderovski DP, et al. Profound block in thymocyte development in mice lacking p56lck. Nature 1992, 357:161-164.
    • (1992) Nature , vol.357 , pp. 161-164
    • Molina, T.J.1    Kishihara, K.2    Siderovski, D.P.3
  • 51
    • 38949210227 scopus 로고    scopus 로고
    • Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation
    • Schade AE, Schieven GL, Townsend R, et al. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 2008, 111:1366-1377.
    • (2008) Blood , vol.111 , pp. 1366-1377
    • Schade, A.E.1    Schieven, G.L.2    Townsend, R.3
  • 52
    • 70449467570 scopus 로고    scopus 로고
    • Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily
    • Sillaber C, Herrmann H, Bennett K, et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest 2009, 39:1098-1109.
    • (2009) Eur J Clin Invest , vol.39 , pp. 1098-1109
    • Sillaber, C.1    Herrmann, H.2    Bennett, K.3
  • 53
    • 84864017153 scopus 로고    scopus 로고
    • Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A
    • Blake SJ, Hughes TP, Lyons AB Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A. Exp Hematol 2012, 40:612-621.
    • (2012) Exp Hematol , vol.40 , pp. 612-621
    • Blake, S.J.1    Hughes, T.P.2    Lyons, A.B.3
  • 54
    • 0027132061 scopus 로고
    • Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II
    • Super HJ, McCabe NR, Thirman MJ, et al. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 1993, 82:3705-3711.
    • (1993) Blood , vol.82 , pp. 3705-3711
    • Super, H.J.1    McCabe, N.R.2    Thirman, M.J.3
  • 55
    • 79957895030 scopus 로고    scopus 로고
    • Evolved tumor suppression: why are we so good at not getting cancer?
    • DeGregori J Evolved tumor suppression: why are we so good at not getting cancer?. Cancer Res 2011, 71:3739-3744.
    • (2011) Cancer Res , vol.71 , pp. 3739-3744
    • DeGregori, J.1
  • 56
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby RA, Gillies RJ A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008, 8:56-61.
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 57
    • 84876133540 scopus 로고    scopus 로고
    • Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?
    • published online July 2.
    • DeGregori J Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?. Oncogene 2012, published online July 2. 10.1038/onc.2012.281.
    • (2012) Oncogene
    • DeGregori, J.1
  • 58
    • 0038092769 scopus 로고    scopus 로고
    • Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
    • Bumm T, Muller C, Al-Ali HK, et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003, 101:1941-1949.
    • (2003) Blood , vol.101 , pp. 1941-1949
    • Bumm, T.1    Muller, C.2    Al-Ali, H.K.3
  • 59
    • 35548939931 scopus 로고    scopus 로고
    • Philadelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia
    • De Melo VA, Milojkovic D, Khorashad JS, et al. Philadelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia. Blood 2007, 110:3086-3087.
    • (2007) Blood , vol.110 , pp. 3086-3087
    • De Melo, V.A.1    Milojkovic, D.2    Khorashad, J.S.3
  • 60
    • 34648833625 scopus 로고    scopus 로고
    • The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells
    • Deininger MW, Cortes J, Paquette R, et al. The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells. Cancer 2007, 110:1509-1519.
    • (2007) Cancer , vol.110 , pp. 1509-1519
    • Deininger, M.W.1    Cortes, J.2    Paquette, R.3
  • 61
    • 33750615550 scopus 로고    scopus 로고
    • Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
    • Kovitz C, Kantarjian H, Garcia-Manero G, Abruzzo LV, Cortes J Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006, 108:2811-2813.
    • (2006) Blood , vol.108 , pp. 2811-2813
    • Kovitz, C.1    Kantarjian, H.2    Garcia-Manero, G.3    Abruzzo, L.V.4    Cortes, J.5
  • 62
    • 0034034557 scopus 로고    scopus 로고
    • Topoisomerase II inhibitor-related acute myeloid leukaemia
    • Pui CH, Relling MV Topoisomerase II inhibitor-related acute myeloid leukaemia. Br J Haematol 2000, 109:13-23.
    • (2000) Br J Haematol , vol.109 , pp. 13-23
    • Pui, C.H.1    Relling, M.V.2
  • 63
    • 14944354802 scopus 로고    scopus 로고
    • Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion
    • Libura J, Slater DJ, Felix CA, Richardson C Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood 2005, 105:2124-2131.
    • (2005) Blood , vol.105 , pp. 2124-2131
    • Libura, J.1    Slater, D.J.2    Felix, C.A.3    Richardson, C.4
  • 64
    • 79955831948 scopus 로고    scopus 로고
    • Relative fitness of hematopoietic progenitors influences leukemia progression
    • Porter CC, Baturin D, Choudhary R, Degregori J Relative fitness of hematopoietic progenitors influences leukemia progression. Leukemia 2011, 25:891-895.
    • (2011) Leukemia , vol.25 , pp. 891-895
    • Porter, C.C.1    Baturin, D.2    Choudhary, R.3    Degregori, J.4
  • 65
    • 0030940742 scopus 로고    scopus 로고
    • Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases
    • Fayad L, Kantarjian H, O'Brien S, et al. Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases. Leukemia 1997, 11:767-771.
    • (1997) Leukemia , vol.11 , pp. 767-771
    • Fayad, L.1    Kantarjian, H.2    O'Brien, S.3
  • 66
    • 33748652419 scopus 로고    scopus 로고
    • What is the right dose? The elusive optimal biologic dose in phase I clinical trials
    • Adjei AA What is the right dose? The elusive optimal biologic dose in phase I clinical trials. J Clin Oncol 2006, 24:4054-4055.
    • (2006) J Clin Oncol , vol.24 , pp. 4054-4055
    • Adjei, A.A.1
  • 67
    • 36749048184 scopus 로고    scopus 로고
    • Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?
    • Ratain MJ, Glassman RH Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?. Clin Cancer Res 2007, 13:6545-6548.
    • (2007) Clin Cancer Res , vol.13 , pp. 6545-6548
    • Ratain, M.J.1    Glassman, R.H.2
  • 68
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005, 23:2445-2459.
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 69
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies RJ, Verduzco D, Gatenby RA Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer 2012, 12:487-493.
    • (2012) Nat Rev Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 70
    • 77951744594 scopus 로고    scopus 로고
    • Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): review from an international consensus conference
    • Horton TM, Sposto R, Brown P, et al. Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): review from an international consensus conference. Pediatr Blood Cancer 2010, 54:872-878.
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 872-878
    • Horton, T.M.1    Sposto, R.2    Brown, P.3
  • 71
    • 84859441677 scopus 로고    scopus 로고
    • Drug development and clinical trials-the path to an approved cancer drug
    • Rubin EH, Gilliland DG Drug development and clinical trials-the path to an approved cancer drug. Nat Rev Clin Oncol 2012, 9:215-222.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 215-222
    • Rubin, E.H.1    Gilliland, D.G.2
  • 72
    • 79960746726 scopus 로고    scopus 로고
    • Randomized phase II trials: a long-term investment with promising returns
    • Sharma MR, Stadler WM, Ratain MJ Randomized phase II trials: a long-term investment with promising returns. J Natl Cancer Inst 2011, 103:1093-1100.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1093-1100
    • Sharma, M.R.1    Stadler, W.M.2    Ratain, M.J.3
  • 74
    • 84861730960 scopus 로고    scopus 로고
    • Molecular prescreening to select patient population in early clinical trials
    • Rodon J, Saura C, Dienstmann R, et al. Molecular prescreening to select patient population in early clinical trials. Nat Rev Clin Oncol 2012, 9:359-366.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 359-366
    • Rodon, J.1    Saura, C.2    Dienstmann, R.3
  • 75
    • 84984568870 scopus 로고    scopus 로고
    • Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities
    • Lacouture ME, Anadkat MJ, Bensadoun RJ, et al. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer 2011, 19:1079-1095.
    • (2011) Support Care Cancer , vol.19 , pp. 1079-1095
    • Lacouture, M.E.1    Anadkat, M.J.2    Bensadoun, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.