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Volumn 40, Issue 8, 2012, Pages

Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; DASATINIB; IMATINIB;

EID: 84864017153     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2012.04.003     Document Type: Article
Times cited : (13)

References (32)
  • 1
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M., Shah N.P., Kantarjian H., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006, 354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 2
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003, 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 3
    • 38949210227 scopus 로고    scopus 로고
    • Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation
    • Schade A.E., Schieven G.L., Townsend R., et al. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 2008, 111:1366-1377.
    • (2008) Blood , vol.111 , pp. 1366-1377
    • Schade, A.E.1    Schieven, G.L.2    Townsend, R.3
  • 4
    • 15244351682 scopus 로고    scopus 로고
    • Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    • Seggewiss R., Lore K., Greiner E., et al. Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 2005, 105:2473-2479.
    • (2005) Blood , vol.105 , pp. 2473-2479
    • Seggewiss, R.1    Lore, K.2    Greiner, E.3
  • 5
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
    • Fruman D.A., Klee C.B., Bierer B.E., Burakoff S.J. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A 1992, 89:3686-3690.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 6
    • 0024976004 scopus 로고
    • Cyclosporine
    • Kahan B.D. Cyclosporine. N Engl J Med 1989, 321:1725-1738.
    • (1989) N Engl J Med , vol.321 , pp. 1725-1738
    • Kahan, B.D.1
  • 7
    • 47249127287 scopus 로고    scopus 로고
    • The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse
    • Huang Y., Comiskey E.O., Dupree R.S., Li S., Koleske A.J., Burkhardt J.K. The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 2008, 112:111-119.
    • (2008) Blood , vol.112 , pp. 111-119
    • Huang, Y.1    Comiskey, E.O.2    Dupree, R.S.3    Li, S.4    Koleske, A.J.5    Burkhardt, J.K.6
  • 8
    • 7944231534 scopus 로고    scopus 로고
    • Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
    • Palacios E.H., Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004, 23:7990-8000.
    • (2004) Oncogene , vol.23 , pp. 7990-8000
    • Palacios, E.H.1    Weiss, A.2
  • 9
    • 0026522204 scopus 로고
    • Profound block in thymocyte development in mice lacking p56lck
    • Molina T.J., Kishihara K., Siderovski D.P., et al. Profound block in thymocyte development in mice lacking p56lck. Nature 1992, 357:161-164.
    • (1992) Nature , vol.357 , pp. 161-164
    • Molina, T.J.1    Kishihara, K.2    Siderovski, D.P.3
  • 10
    • 29144464371 scopus 로고    scopus 로고
    • Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
    • Manley P.W., Cowan-Jacob S.W., Mestan J. Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochim Biophys Acta 2005, 1754:3-13.
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 3-13
    • Manley, P.W.1    Cowan-Jacob, S.W.2    Mestan, J.3
  • 11
    • 63049131627 scopus 로고    scopus 로고
    • Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro
    • Blake S.J., Lyons A.B., Hughes T.P. Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro. J Cell Mol Med 2009, 13:599-601.
    • (2009) J Cell Mol Med , vol.13 , pp. 599-601
    • Blake, S.J.1    Lyons, A.B.2    Hughes, T.P.3
  • 12
    • 53749086585 scopus 로고    scopus 로고
    • Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signaling
    • Chen J., Schmitt A., Chen B., et al. Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signaling. J Cell Mol Med 2008, 12:2107-2118.
    • (2008) J Cell Mol Med , vol.12 , pp. 2107-2118
    • Chen, J.1    Schmitt, A.2    Chen, B.3
  • 13
    • 45449102076 scopus 로고    scopus 로고
    • The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro
    • Blake S., Hughes T.P., Mayrhofer G., Lyons A.B. The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro. Clin Immunol 2008, 127:330-339.
    • (2008) Clin Immunol , vol.127 , pp. 330-339
    • Blake, S.1    Hughes, T.P.2    Mayrhofer, G.3    Lyons, A.B.4
  • 14
    • 58149181387 scopus 로고    scopus 로고
    • Dasatinib inhibits recombinant viral antigen-specific murine CD4(+) and CD8(+) T-cell responses and NK-cell cytolytic activity in vitro and in vivo
    • Fraser C.K., Blake S.J., Diener K.R., et al. Dasatinib inhibits recombinant viral antigen-specific murine CD4(+) and CD8(+) T-cell responses and NK-cell cytolytic activity in vitro and in vivo. Exp Hematol 2009, 37:256-265.
    • (2009) Exp Hematol , vol.37 , pp. 256-265
    • Fraser, C.K.1    Blake, S.J.2    Diener, K.R.3
  • 15
    • 52049085750 scopus 로고    scopus 로고
    • Dasatinib exerts an immunosuppressive effect on CD8(+) T cells specific for viral and leukemia antigens
    • Fei F., Yu Y., Schmitt A., et al. Dasatinib exerts an immunosuppressive effect on CD8(+) T cells specific for viral and leukemia antigens. Exp Hematol 2008, 36:1297-1308.
    • (2008) Exp Hematol , vol.36 , pp. 1297-1308
    • Fei, F.1    Yu, Y.2    Schmitt, A.3
  • 16
    • 42249088418 scopus 로고    scopus 로고
    • Profound inhibition of antigen-specific T-cell effector functions by dasatinib
    • Weichsel R., Dix C., Wooldridge L., et al. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res 2008, 14:2484-2491.
    • (2008) Clin Cancer Res , vol.14 , pp. 2484-2491
    • Weichsel, R.1    Dix, C.2    Wooldridge, L.3
  • 17
    • 70449467570 scopus 로고    scopus 로고
    • Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily
    • Sillaber C., Herrmann H., Bennett K., et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest 2009, 39:1098-1109.
    • (2009) Eur J Clin Invest , vol.39 , pp. 1098-1109
    • Sillaber, C.1    Herrmann, H.2    Bennett, K.3
  • 18
    • 37149025629 scopus 로고    scopus 로고
    • Viral infection or reactivation in patients during treatment with dasatinib: a call for screening?
    • Torres H.A., Chemaly R.F. Viral infection or reactivation in patients during treatment with dasatinib: a call for screening?. Leuk Lymphoma 2007, 48:2308-2309.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2308-2309
    • Torres, H.A.1    Chemaly, R.F.2
  • 19
    • 84863991846 scopus 로고    scopus 로고
    • The addition of cyclosporine to dasatinib therapy of murine Bcr-Abl+ leukemia improves disease control independent of altered pharmacokinetics
    • Porter C.C., Gregory M.A., Zaberezhnyy V., Klawitter J., Christians U., DeGregori J. The addition of cyclosporine to dasatinib therapy of murine Bcr-Abl+ leukemia improves disease control independent of altered pharmacokinetics. ASH Annual Meeting Abstracts 2010, 116:600.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 600
    • Porter, C.C.1    Gregory, M.A.2    Zaberezhnyy, V.3    Klawitter, J.4    Christians, U.5    DeGregori, J.6
  • 20
    • 77954299059 scopus 로고    scopus 로고
    • Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
    • Gregory M.A., Phang T.L., Neviani P., et al. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell 2010, 18:74-87.
    • (2010) Cancer Cell , vol.18 , pp. 74-87
    • Gregory, M.A.1    Phang, T.L.2    Neviani, P.3
  • 21
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou T.C., Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984, 22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 22
    • 0034699367 scopus 로고    scopus 로고
    • Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution
    • Lyons A.B. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 2000, 243:147-154.
    • (2000) J Immunol Methods , vol.243 , pp. 147-154
    • Lyons, A.B.1
  • 23
    • 0028262128 scopus 로고
    • Determination of lymphocyte division by flow cytometry
    • Lyons A.B., Parish C.R. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994, 171:131-137.
    • (1994) J Immunol Methods , vol.171 , pp. 131-137
    • Lyons, A.B.1    Parish, C.R.2
  • 24
    • 33947195450 scopus 로고    scopus 로고
    • Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells
    • Flaig T.W., Su L.J., Harrison G., Agarwal R., Glode L.M. Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. Int J Cancer 2007, 120:2028-2033.
    • (2007) Int J Cancer , vol.120 , pp. 2028-2033
    • Flaig, T.W.1    Su, L.J.2    Harrison, G.3    Agarwal, R.4    Glode, L.M.5
  • 25
    • 0034889197 scopus 로고    scopus 로고
    • Drug synergism: its detection and applications
    • Tallarida R.J. Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001, 298:865-872.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 865-872
    • Tallarida, R.J.1
  • 26
    • 58149094991 scopus 로고    scopus 로고
    • Dasatinib inhibits the proliferation and function of CD4+CD25+ regulatory T cells
    • Fei F., Yu Y., Schmitt A., et al. Dasatinib inhibits the proliferation and function of CD4+CD25+ regulatory T cells. Br J Haematol 2009, 144:195-205.
    • (2009) Br J Haematol , vol.144 , pp. 195-205
    • Fei, F.1    Yu, Y.2    Schmitt, A.3
  • 27
    • 0038783708 scopus 로고    scopus 로고
    • Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes
    • Chen C., Lee W.H., Yun P., Snow P., Liu C.P. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J Immunol 2003, 171:733-744.
    • (2003) J Immunol , vol.171 , pp. 733-744
    • Chen, C.1    Lee, W.H.2    Yun, P.3    Snow, P.4    Liu, C.P.5
  • 28
    • 52449100460 scopus 로고    scopus 로고
    • Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications
    • Hiwase D.K., Saunders V., Hewett D., et al. Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin Cancer Res 2008, 14:3881-3888.
    • (2008) Clin Cancer Res , vol.14 , pp. 3881-3888
    • Hiwase, D.K.1    Saunders, V.2    Hewett, D.3
  • 29
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study
    • Ottmann O., Dombret H., Martinelli G., et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007, 110:2309-2315.
    • (2007) Blood , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3
  • 30
    • 68749108104 scopus 로고    scopus 로고
    • Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy
    • Mustjoki S., Ekblom M., Arstila T.P., et al. Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia 2009, 23:1398-1405.
    • (2009) Leukemia , vol.23 , pp. 1398-1405
    • Mustjoki, S.1    Ekblom, M.2    Arstila, T.P.3
  • 31
    • 43449091001 scopus 로고    scopus 로고
    • Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis
    • de Lavallade H., Punnialingam S., Milojkovic D., et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008, 141:745-747.
    • (2008) Br J Haematol , vol.141 , pp. 745-747
    • de Lavallade, H.1    Punnialingam, S.2    Milojkovic, D.3
  • 32
    • 77956280601 scopus 로고    scopus 로고
    • Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy
    • Kreutzman A., Juvonen V., Kairisto V., et al. Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy. Blood 2010, 116:772-782.
    • (2010) Blood , vol.116 , pp. 772-782
    • Kreutzman, A.1    Juvonen, V.2    Kairisto, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.