High glucose and free fatty acids induce beta cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor

Purinergic Signalling

Volumn 9, Issue 1, 2013, Pages 67-79

  Tan, Chanyuan ^a   Voss, Ulrikke ^b   Svensson, Siv ^a   Erlinge, David ^a   Olde, Björn ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Apoptosis; Beta cell; Glucose; MIN6 cell; Palmitate

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBENOXOLONE; CASPASE 3; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIAZOXIDE; FATTY ACID; GLUCOSE; INSULIN; MANNITOL; MULTIDRUG RESISTANCE PROTEIN 1; NIFEDIPINE; PALMITIC ACID; PURINERGIC P2Y13 RECEPTOR; TOLBUTAMIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ELISA KIT; FEMALE; GENE EXPRESSION; GENE SILENCING; IMMUNOCYTOCHEMISTRY; MICROSCOPY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; RNA EXTRACTION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

EID: 84873745779     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-012-9331-6     Document Type: Article

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