Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability

Journal of Membrane Biology

Volumn 183, Issue 3, 2001, Pages 165-173

  Roman, R M ^a   Lomri, N ^b   Braunstein, G ^c   Feranchak, A P ^a   Simeoni, L A ^e   Davison, A K ^a   Mechetner, E ^d   Schwiebert, E M ^c   Fitz, J G ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITÉ DE CERGY PONTOISE   (France)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF BRASILIA   (Brazil)

^e Oncotech Inc   (United States)

Author keywords

ABC protein; Cell volume; Cl channel; Liver; Purinergic receptor

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; CYCLOSPORIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PURINE RECEPTOR; RHODAMINE 123; VERAPAMIL;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; CELL MEMBRANE; CELL VOLUME; CHLORIDE CURRENT; GENE OVEREXPRESSION; HEPATOMA CELL; LIVER CELL; MEMBRANE PERMEABILITY; MULTIDRUG RESISTANCE; NONHUMAN; PATCH CLAMP; RAT;

3T3 CELLS; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIBODIES; CARCINOMA, HEPATOCELLULAR; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELLS, CULTURED; CHLORIDES; CYCLOSPORINE; HUMANS; MICE; P-GLYCOPROTEIN; P-GLYCOPROTEINS; RATS; TUMOR CELLS, CULTURED; VERAPAMIL;

ANIMALIA;

EID: 0035476122     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-001-0064-7     Document Type: Article

References (28)

1. The multidrug re sistance (mdr1) gene product functions as an ATP channel
2. Enhanced secretion of glycocholic acid in a novel cell line is associated with upregulation of genes encoding for ATP-binding cassette proteins
3. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene
4. Association and stoichiometry of K(ATP) channel subunits
5. Phosphatidyl inositol 3-kinase represents a novel signal regulating cell volume through effects on ATP release
6. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies
7. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
8. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein
9. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli
10. 2-purinergic receptors: Subtype-associated signaling responses and structure
11. MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors
12. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
13. Cystic fibrosis transmembrane conductance regulator-associated ATP and adenosine 3′-phosphate 5′-phosphosulfate channels in endoplasmic reticulum and plasma membranes
14. Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP
15. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel
16. 3+ inhibition of membrane ATP permeability and purinergic signaling
17. Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function
18. Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume
19. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
20. Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates
21. - channel and CFTR-associated ATP channel: Distinct pores regulated by common gates
22. Bioluminescence detection of ATP release mechanisms in epithelia
23. Monoclonal antibodies against MDR1 P-glycoprotein inhibit chloride conductance and label a 65-kDa protein in pancreatic zymogen granule membranes
24. Immunoblotting in the clinical laboratory
25. - channel regulator
26. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation
27. ATP-activated chloride channel inhibited by an antibody to P glycoprotein
28. The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2