MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells

Cellular and Molecular Life Sciences

Volumn 70, Issue 4, 2013, Pages 711-728

  Jung, Jin Sun ^a   Jee, Min Ki ^a   Cho, Hyun Tae ^a   Choi, Jee In ^a   Im, Young Bin ^a   Kwon, Oh Hyun ^a   Kang, Soo Kyung ^a  

^a Seoul National University   (South Korea)

Author keywords

Ago2; hATSC; Methyl CpG binding protein 6; Oct4

Indexed keywords

ARGONAUTE 2 PROTEIN; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 6; MICROTUBULE ASSOCIATED PROTEIN 2; OCTAMER TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

ADIPOSE TISSUE; ADULT; ADULT STEM CELLS; ARGONAUTE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MULTIGENE FAMILY; OCTAMER TRANSCRIPTION FACTOR-3; UP-REGULATION;

EID: 84873744865     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1157-4     Document Type: Article

References (37)

1. Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ (2005) Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA 102:12135-12140
2. Jang JH, Jung JS, Im YB, Kang KS, Choi JI, Kang SK (2012) Crucial role of nuclear Ago2 for hUCB-MSCs differentiation and self-renewal via stemness control. Antioxid Redox Signal 16:95-111
3. Tan GS, Garchow BG, Liu X, Yeung J, Morris JPt, Cuellar TL, McManus MT, Kiriakidou M (2009) Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res 37:7533-7545
4. Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP (2005) The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310:1817-1821
5. Norddahl GL, Pronk CJ, Wahlestedt M, Sten G, Nygren JM, Ugale A, Sigvardsson M, Bryder D (2011) Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 8:499-510
6. Chambers I, Smith A (2004) Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23:7150-7160
7. Kang SK, Lee DH, Bae YC, Kim HK, Baik SY, Jung JS (2003) Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 183:355-366
8. Kelly DP (2011) Cell biology: ageing theories unified. Nature 470:342-343
9. Kim JH, Lee MR, Jee MK, Kang SK (2008) Selenium induces improvement of stem cell behaviors in human adipose-tissue stromal cells via SAPK/JNK and stemness acting signals. Stem Cells 26:2724-2734
10. Mattson MP (2011) A reaction to mitochondria in action. Cell Res 21:279-282
11. Kim BS, Jung JS, Jang JH, Kang KS, Kang SK (2011) Nuclear Argonaute 2 regulates adipose tissue-derived stem cell survival through direct control of miR10b and selenoprotein N1 expression. Aging Cell 10:277-291
12. Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T (2004) Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell 15:185-197
13. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676
14. Yamanaka S, Takahashi K (2006) Induction of pluripotent stem cells from mouse fibroblast cultures. Tanpakushitsu Kakusan Koso 51:2346-2351
15. Davey C, Pennings S, Allan J (1997) CpG methylation remodels chromatin structure in vitro. J Mol Biol 267:276-288
16. Kass SU, Pruss D, Wolffe AP (1997) How does DNA methylation repress transcription? Trends Genet 13:444-449
17. Ng HH, Bird A (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9:158-163
18. Razin A (1998) CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17:4905-4908
19. Meehan RR, Lewis JD, McKay S, Kleiner EL, Bird AP (1989) Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58:499-507
20. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19:187-191
21. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389
22. Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (1999) MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet 23:58-61
23. Cross SH, Meehan RR, Nan X, Bird A (1997) A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet 16:256-259
24. Hendrich B, Bird A (1998) Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol 18:6538-6547
25. Ohki I, Shimotake N, Fujita N, Nakao M, Shirakawa M (1999) Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1. EMBO J 18:6653-6661
26. Wakefield RI, Smith BO, Nan X, Free A, Soteriou A, Uhrin D, Bird AP, Barlow PN (1999) The solution structure of the domain from MeCP2 that binds to methylated DNA. J Mol Biol 291:1055-1065
27. Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 23:62-66
28. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13:1924-1935
29. Jang JH, Jung JS, Choi JI, Kang SK (2012) Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation. Antioxid Redox Signal 16(5):383-399
30. Jiang CL, Jin SG, Pfeifer GP (2004) MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. J Biol Chem 279:52456-52464
31. Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (2002) MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. J Biol Chem 277:48714-48723
32. Zhu D, Fang J, Li Y, Zhang J (2009) Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation. PLoS ONE 4:e7684
33. Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Stoerker J, Genuardi M, Yeung AT, Matsumoto Y, Bellacosa A (2000) Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase. J Biol Chem 275:32422-32429
34. Tatematsu KI, Yamazaki T, Ishikawa F (2000) MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. Genes Cells 5:677-688
35. Zhang Y, van Deursen J, Galardy PJ (2011) Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. PLoS ONE 6:e23389
36. Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M (2010) BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol 17:1461-1469
37. Laget S, Joulie M, Le Masson F, Sasai N, Christians E, Pradhan S, Roberts RJ, Defossez PA (2010) The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA. PLoS ONE 5:e11982