Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Tamokou, Jean de Dieu ^a,e   Chouna, Jean Rodolphe ^a,e   Fischer Fodor, Eva ^b   Chereches, Gabriela ^b   Barbos, Otilia ^b   Damian, Grigore ^a   Benedec, Daniela ^c   Duma, Mihaela ^d   Efouet, Alango Pépin Nkeng ^e   Wabo, Hippolyte Kamdem ^e   Kuiate, Jules Roger ^e   Mot, Augustin ^a   Silaghi Dumitrescu, Radu ^a  

^a BABE BOLYAI UNIVERSITY   (Romania)

^b THE ONCOLOGY INSTITUTE PROF DR ION CHIRICUTA   (Romania)

^c IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d State Veterinary Laboratory for Animal Health and Safety   (Romania)

^e UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2 GERANYLEMODIN; 3 GERANYLOXYEMODIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; CISPLATIN; DICHROSTACHYS GLOMERATA EXTRACT; EMODIN; FICUS ASPERIFOLIA EXTRACT; GENTAMICIN; HIBISCUS ASPER EXTRACT; PAULLINIA PINNATA EXTRACT; PENTADESMA BUTYRACEA EXTRACT; PLANT EXTRACT; PSOROSPERMUM FEBRIFUGUM EXTRACT; RUMEX ABYSSINICUS EXTRACT; RUMEX BEQUAERTII EXTRACT; TECTONA GRANDIS EXTRACT; UNCLASSIFIED DRUG; VISMIA LAURENTII EXTRACT;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CAMEROON; COLORIMETRY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DICHROSTACHYS GLOMERATA; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ESCHERICHIA COLI; FEMALE; FICUS ASPERIFOLIA; HEMOGLOBULIN ASCORBATE PEROXIDASE ACTIVITY INHIBITION ASSAY; HIBISCUS ASPER; HUMAN; HUMAN CELL; IC 50; LISTERIA MONOCYTOGENES; MEDICAL PROCEDURES; MEDICINAL PLANT; NONHUMAN; PAULLINIA PINNATA; PENTADESMA BUTYRACEA; PSOROSPERMUM FEBRIFUGUM; RUMEX ABYSSINICUS; RUMEX BEQUAERTII; SALMONELLA TYPHIMURIUM; SPECTROPHOTOMETRY; STAPHYLOCOCCUS AUREUS; TECTONA GRANDIS; TROLOX EQUIVALENT ANTIOXIDANT CAPACITY; VISMIA LAURENTII;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; PHENOL; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANTS, MEDICINAL; SPECTRUM ANALYSIS;

EID: 84873735501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055880     Document Type: Article

References (76)

1. Hritcu L, Foyet HS, Stefan M, Mihasan M, Asongalem AE, et al. (2011) Neuroprotective effect of the methanolic extract of Hibiscus asper leaves in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. J Ethnopharmacol 137: 585-591.
2. Foyet HS, Hritcu L, Ciobica A, Stefan M, Kamtchouing P, et al. (2011) Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease. J Ethnopharmacol 133: 773-779.
3. Lacret R, Varela RM, Molinillo JM, Nogueiras C, Macías FA, (2011) Anthratectone and naphthotectone, two quinones from bioactive extracts of Tectona grandis. J Chem Ecol 37: 1341-1348.
4. Neamatallah A, Yan L, Dewar SJ, Austin B, (2005) An extract from teak (Tectona grandis) bark inhibited Listeria monocytogenes and methicillin resistant Staphylococcus aureus. Lett Appl Microbiol 41: 94-96.
5. Jagetia GC, Baliga MS, (2004) The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. J Med Food 7: 343-348.
6. Khan RM, Mlungwana SM, (1998) 5-Hydroxylapachol: a cytotoxic agent from Tectona grandis. Phytochemistry 50: 439-442.
7. Watcho P, Ngadjui E, Alango Nkeng-Efouet P, Benoît Nguelefack T, Kamanyi A, (2011) Evaluation of in vitro uterotonic activities of fruit extracts of Ficus asperifolia in rats. Evid Based Complement Alternat Med 2011: 783413 doi:10.1093/ecam/nep221.
8. Ayim JA, Bayor MT, Phillips RM, Shnyder SD, Wright CW, (2007) The evaluation of selected Ghanaian medicinal plants for cytotoxic activites. J Sci Technol (Ghana) 27: 16-22.
9. Annan K, Houghton PJ, (2008) Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana. J Ethnopharmacol 119: 141-144.
10. Cos P, Hermans N, De BT, Apers S, Sindambiwe JB, et al. (2002) Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1). Phytomedicine 9: 62-68.
11. Zelefack F, Guilet D, Fabre N, Bayet C, Chevalley S, et al, (2009) Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. J Nat Prod 72: 954-957.
12. Lenta BN, Kamdem LM, Ngouela S, Tantangmo F, Devkota KP, et al. (2011) Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea. Planta Med 77: 377-379.
13. Nguemeving JR, Azebaze AG, Kuete V, Eric Carly NN, Beng VP, et al. (2006) Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii. 67: 1341-1346.
14. Wabo HK, Kouam SF, Krohn K, Hussain H, Tala MF, et al. (2007) Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii. Chem Pharm Bull (Tokyo) 55: 1640-1642.
15. Noungoue DT, Antheaume C, Chaabi M, Lenta Ndjakou B, Ngouela S,et al. Anthraquinones from the fruits of Vismia laurentii. Phytochemistry 69: 1024-1028.
16. Kuete V, Wabo HK, Eyong KO, Feussi MT, Wiench B, et al, (2011) Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS One 6(8): e21762 doi:10.1371/journal.pone.0021762.
17. Kuete V, Nguemeving JR, Beng VP, Azebaze AG, Etoa FX, et al. (2007) Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae). J Ethnopharmacol 109: 372-379.
18. Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, et al. (2009) Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C 64: 210-214.
19. Annan K, Houghton PJ, (2010) Two novel lupane triterpenoids from Paullinia pinnata L. with fibroblast stimulatory activity. J Pharm Pharmacol 62: 663-668.
20. Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, et al. (2006) Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms. J Cardiovasc Pharmacol 47: 599-608.
21. Fankam AG, Kuete V, Voukeng IK, Kuiate JR, Pages JM, (2011) Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complement Altern Med 11: 104 doi:10.1186/1472-6882-11-104.
22. Permana PA, Ho DK, Cassady JM, Snapka RM, (1994) Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links. Cancer Res 54: 3191-3195.
23. Kisangau DP, Hosea KM, Joseph CC, Lyaruu HV, (2007) In vitro antimicrobial assay of plants used in traditional medicine in Bukoba Rural district, Tanzania. Afr J Tradit Complement Altern Med 4: 510-523.
24. Tsaffack M, Nguemeving JR, Kuete V, Ndejouong Tchize Ble S, Mkounga P, et al. (2009) Two new antimicrobial dimeric compounds: febrifuquinone, a vismione-anthraquinone coupled pigment and adamabianthrone, from two Psorospermum species. Chem Pharm Bull (Tokyo). 57: 1113-1118.
25. Wang XD, Gu LQ, Wu JY, (2007) Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells. Biol Pharm Bull 30: 1113-1116.
26. Suboj P, Babykutty S, Srinivas P, Gopala S, (2012) Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells. Pharmacology 89: 91-98.
27. Li J, Liu P, Mao H, Wanga A, Zhang X, (2009) Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro. Oncol Rep 21: 1605-1610.
28. Ok S, Kim SM, Kim C, Nam D, Shim BS, et al. (2012) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4. Immunopharmacol Immunotoxicol PMID: 22299827. doi:10.3109/08923973.2012.654494.
29. Su YJ, Tsai MS, Kuo YH, Chiu YF, Cheng CM, et al. (2010) Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. Mol Pharmacol 77: 633-643.
30. Liu DL, Bu H, Li H, Chen H, Guo HC, et al. (2012) Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. Int J Oncol 40: 1049-1057.
31. Kerharo JO (1974) Pharmacopée Sénégalaise Traditionnelle. Paris: Vigot Frères. 485 p.
32. Bamps P, (1966) Note sur les Guttiféracées d'Afrique Tropicale. Jard Bot Nat Bruxelles 36: 315-319.
33. Bamps P, (1970) Flore du Congo, du Rwanda et du Burundi. Jard Bot Nat Bruxelles X: 24-31.
34. Irvine FR (1961) Woody plants of Ghana. London: Oxford University Press. 194, 208, 548.
35. Abbiw D (1990) Useful Plants of Ghana. London: Intermediate Technology Publication Ltd. 182-205.
36. Sinsin B, Sinadouwirou TA, (2003) Socio-economic utilization of Pentadesma butyraceae sabine and its substainability in gallery forest of Benin. Cah Agric 12: 75-79.
37. Tchobo F, Natta A, Barea B, Barouh N, Piombo G, et al. (2007) Characterization of Pentadesma butyracea sabine butters of different production regions in Benin. J Am Oil Chem Soc 84: 755-760.
38. Kupcha SM, Streelman DR, Sneden AT, (1980) Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum. J Nat Prod 43: 296-301.
39. Uphof JC (1968) Dictionary of economic plants. New York: Strechert Hafner Service Agency Inc. 434 p.
40. Watt JM, Brayer-Brandwijk MG (1962) The medicinal and poisonous plants of Southern and Eastern Africa. Edinburgh: Livingstone Ltd. 494-500.
41. Rao KNV, Sunitha C, Banji D, Sandhya S, Mahesh V, (2011) A study on the nutraceuticals from the genus Rumex. Hygeia J D Med 3: 76-88.
42. Annan K, Gbedema SY, Adu F, (2009) Antibacterial and radical scavenging activity of fatty acids from Paullinia pinnata L. Phcog Mag. 4: 119-123.
43. Varier PS (1996) Indian medicinal plants: a compendium of 500 species. Hyderabad: Orient Longman. 245-248.
44. Khare CP (2007). Indian medicinal plants: an illustrated dictionary. Heidelberg: Springer Verlag. 649 p.
45. Cos P, Hermans N, De BT, Apers S, Sindambiwe JB, et al. (2002) Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1). Phytomedicine 9: 62-68.
46. Koudou J, Roblof G, Wylde R, Heitz A, (1994) Constituents of the hexane extract from Dichrostachys glomerata. Planta Medica 60: 96-97.
47. Agon AV, Kinnoudou C (2004) Antiviral, anti-infectious and cicatrising properties of extracts of Dichrostachys glomerata. Patent no. WO2004/052384 A1.
48. Botta B, Delle MF, Delle MG, Marini BGB, Msonthi JD, (1985) Prenylated bianthrones and vismione F from Psorospermum febrifugum. Phytochemistry 24: 827-830.
49. Botta B, Delle MF, Delle MG, Marini BGB, Oguakwa JU, (1983) 3-geranyloxy-6-methyl-1,8-dihydroxyantraquinone and vismiones C, D and E from Psorospermum febrifugum. Phytochemistry 22: 539-542.
50. Mahato BS, Kundu AP, (1994) 13C NMR spectra of pentacyclic triterpenoids; a compilation and some salient features. Phytochemistry 37: 1517-1575.
51. International Organization for Standardization (ISO) 14502-1 (2005) Determination of substances characteristic of green and black tea. Part 1: Content of total polyphenols in tea. Colorimetric method using Folin-Ciocalteu reagent.
52. Brand-Williams W, Cuvelier ME, Berset C, (1995) Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci Technol 28: 25-30.
53. Mot AC, Silaghi-Dumitrescu R, Sarbu C, (2011) Rapid and effective evaluation of the antioxidant capacity of propolis extracts using DPPH bleaching kinetic profiles, FT-IR and UV-vis spectroscopic data. J Food Comp Anal 24: 516-522.
54. Rice-Evans C, Miller NJ, (1994) Total antioxidant status in plasma and body fluids. Methods Enzymol 234: 279-293.
55. Mot AC, Parvu M, Damian G, Irimie FD, Darula Z, et al. (2012) A "yellow" laccase with "blue" spectroscopic features, from Sclerotinia sclerotiorum. Process Biochem 47: 968-975.
56. Antonini E, Brunori M (1971) Hemoglobin and myoglobin in their reaction with ligands. Amsterdam: North-Holland.
57. Cooper CE, Silaghi-Dumitrescu R, Rukengwa M, Alayash AI, Buehler PW, (2008) Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of hemoglobin-based oxygen carriers (HBOC). Biochim Biophys Acta 1784: 1415-1420.
58. Lad L, Mewies M, Basran J, Scrutton NS, Raven EL, (2002) Role of histidine 42 in ascorbate peroxidase. Kinetic analysis of the H42A and H42E variants. Eur J Biochem 269: 3182-3192.
59. Lázár-Molnár E, Hegyesi H, Pállinger E, Kovács P, Tóth S, et al. (2002) Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6. Eur J Clin Invest 32: 743-749.
60. Virag P, Brie I, Postescu ID, Perde-Schrepler M, Fischer-Fodor E, et al. (2009) Comparative study of two evaluation methods for the genotoxic effects of environmental heavy metals on normal cells. Toxicol Ind Health 25: 253-258.
61. Mosmann T, (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
62. Perde-Schrepler M, Chereches G, Brie L, Virag P, Barbos O, et al. (2011) Photoprotective effect of Calluna vulgaris extract against UVB-induced phototoxicity in human immortalized keratinocytes. J Environ Pathol Toxicol Oncol 30: 323-331.
63. Vorauer K, Steindl F, Jungbauer A, Hahn R, Katinger H, (1996) Cytokine activity assay by means of proliferation measured in plane convex microtiter wells. J Biochem Biophys Methods 32: 85-96.
64. Reeves DS, White LO (1983) Principles of methods of assaying antibiotics in pharmaceutical microbiology. Oxford: Blackwel. 140-162.
65. Singleton VL, Orthofer R, Lamuela-Raventos RM, (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Method Enzymol 299: 152-178.
66. Koyama J, Nisino Y, Morita I, Kobayashi N, Osakai T, et al. (2008) Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives. Bioorg Med Chem Lett 18: 4106-4109.
67. Mahesh SK, Jayakumaran NA, (2010) Antibacterial, cytotoxic and antioxidant potential of different extracts from leaf, bark and wood of Tectona grandis. Int J Pharma Sci Drug Res 2: 155-158.
68. Mot AC, Damian G, Sarbu C, Silaghi-Dumitrescu R, (2009) Redox reactivity in propolis: direct detection of free radicals in basic medium and interaction with haemoglobin. Redox Rep 14: 267-274.
69. Pietta P, Sionetti P, Mauri P, (1998) Antioxidant activity of selected medicinal plants. J Agric Food Chem 46: 4487-4490.
70. Jimoh FO, Sofidiya MO, Afolayan AJ, (2007) Antioxidant properties of the methanol extracts from the leaves of Paullinia pinnata. J Med Food 10: 707-711.
71. Getie M, Gebre-Mariam T, Rietz R, Höhne C, Huschka C, et al. (2003) Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus. Fitoterapia 74: 139-143.
72. Muscolini M, Montagni E, Caristi S, Nomura T, Kamada R, et al. (2009) Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain. Cell Cycle 8: 3396-3405.
73. Muscolini M, Montagni E, Palermo V, Di Agostino S, Gu W, et al. (2011) The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein. J Biol Chem 286: 39693-39702.
74. Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J, et al. (1987) Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 47: 414-418.
75. Yan X, Fraser M, Qiu Q, Tsang BK, (2006) Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. Gynecol Oncol 102: 348-355.
76. Karasic TB, Hei TK, Ivanov VN, (2010) Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Exp Cell Res 316: 1994-2007.