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Volumn 21, Issue 5, 2013, Pages 1284-1304

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

(10) Niculescu Duvaz, Dan a Niculescu Duvaz, Ion a Suijkerbuijk, Bart M J M a Ménard, Delphine a Zambon, Alfonso a Davies, Lawrence a Pons, Jean Francois b Whittaker, Steven a Marais, Richard c Springer, Caroline J a

a INSTITUTE OF CANCER RESEARCH (United Kingdom)

b EVOTEC UK LTD (United Kingdom)

c UNIVERSITY OF MANCHESTER (United Kingdom)

Author keywords

Anticancer; BRAF; Kinase inhibitors; Melanoma; Triarylimidazole

Indexed keywords

(6 BROMO 3,4 DIHYDRO NAPHTHALEN 1 YLOXY)TRIISOPROPYL SILANE; (6 BROMO BENZOFURAN 3 YL)METHANOL; (6 BROMO NAPHTHALEN 1 YLOXY)TRIISOPROPYL SILANE; 1 (4 BROMO PHENYL) 2,2,2 TRIFLUORO ETHANOL; 1 (5 BROMO BENZO[B]THIOPHEN 2 YL) 2,2,2 TRIFLUORO ETHANOL; 1 (5 BROMO BENZO[B]THIOPHEN 2 YL) 2,2,2 TRIFLUORO ETHANONE; 1 (6 BROMO BENZO[B]THIOPHEN 3 YL) 2,2,2 TRIFLUORO ETHANOL; 1 (6 BROMO BENZO[B]THIOPHEN 3 YL) 2,2,2 TRIFLUORO ETHANONE; 1 (6 BROMO BENZO[B]THIOPHEN 3 YL) 2,2,3,3,3 PENTAFLUORO PROPAN 1 OL; 1 (6 BROMO BENZO[B]THIOPHEN 3 YL) 2,2,3,3,3 PENTAFLUORO PROPAN 1 ONE; 1 [6 (4,4,5,5 TETRAMETHYL [1,3,2]DIOXABOROLAN 2 YL)BENZO[B]THIOPHEN 3 YL]PROPAN 1 OL; 1 [6 [2 [4 (2 DIMETHYLAMINO ETHOXY)PHENYL] 5 (PYRIDIN 4 YL) 1H IMIDAZOL 4 YL] BENZO[B]THIOPHEN 3 YL] 2,2,2 TRIFLUOROETHANOL; 2,2,3,3,3 PENTAFLUORO N,N DIMETHYL PROPIONAMIDE; 3,6 DIBROMOBENZO[B]THIOPHENE; 6 [2 [4 (2 DIMETHYLAMINO ETHOXY)PHENYL] 5 PYRIDIN 4 YL 3H IMIDAZOL 4 YL]NAPHTHALEN 1 OL; 6 BROMO 3 METHYLSULFANYL BENZO[B]THIOPHENE; 6 BROMO 3 PROPYLSULFANYL BENZO[B]THIOPHENE; 6 BROMO 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 6 BROMO BENZO[B]THIOPHENE 3 CARBALDEHYDE; 6 BROMOBENZOFURAN 3 CARBOXYLIC ACID; 6 BROMOBENZOFURAN 3 CARBOXYLIC ACID AMIDE; 6 BROMOBENZOTHIOPHENE; 6 BROMOBENZOTHIOPHENE 2 CARBOXYLIC ACID; 6 BROMONAPHTHALEN 1 OL; 7 BROMO NAPHTHALEN 2 OL; B RAF KINASE INHIBITOR; ETHYL 6 BROMOBENZOFURAN 3 CARBOXYLIC ACID; ETHYL 6 BROMOBENZOTHIOPHENE 2 CARBOXYLIC ACID; HYDROXY 4 BROMOBENZALDEHYDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

BENZOFURANS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; IMIDAZOLES; MELANOMA; NAPHTHOLS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84873732705 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.035 Document Type: Article

Times cited : (37)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.