Non-oxime inhibitors of B-RafV600E kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1243-1247

  Ren, Li ^a   Wenglowsky, Steve ^a   Miknis, Greg ^a   Rast, Bryson ^a   Buckmelter, Alex J ^a   Ely, Robert J ^a   Schlachter, Stephen ^a   Laird, Ellen R ^a   Randolph, Nikole ^a   Callejo, Michele ^a   Martinson, Matthew ^a   Galbraith, Sarah ^a   Brandhuber, Barbara J ^a   Vigers, Guy ^a   Morales, Tony ^a   Voegtli, Walter C ^a   Lyssikatos, Joseph ^b  

^a ARRAY BIOPHARMA INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

B Raf; Furopyridine; Indazole

Indexed keywords

1 NAPHTHOL; AMIDINE; B RAF KINASE INHIBITOR; CHLOROINDAZOLE; HYDROXYAMIDINE; INDANONE DERIVATIVE; INDAZOLE DERIVATIVE; OXIME DERIVATIVE; PHENOL; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ENZYME INHIBITION; HYDROGEN BOND; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDAZOLES; MICE; MICROSOMES, LIVER; MUTATION; OXIMES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 79851511778     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.061     Document Type: Article

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