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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1177-1181

Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening

(11) Nettekoven, Matthias a Fingerle, Jürgen a Grether, Uwe a Grüner, Sabine a Kimbara, Atsushi a Püllmann, Bernd a Rogers Evans, Mark a Röver, Stephan a Schuler, Franz a Schulz Gasch, Tanja a Ullmer, Christoph a

a F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

Arrestin; Adamantane; Cannabinoid receptor; Hit optimization

Indexed keywords

BETA ARRESTIN; CANNABINOID 2 RECEPTOR AGONIST;

ARTICLE; BINDING SITE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADAMANTANE; CANNABINOID RECEPTOR AGONISTS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873732129 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.01.044 Document Type: Article

Times cited : (13)

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