BRCA1 expression in a large series of sporadic ovarian carcinomas: A Gynecologic Oncology Group study

International Journal of Gynecological Cancer

Volumn 16, Issue SUPPL. 1, 2006, Pages 166-171

  Thrall, M ^a   Gallion, H H ^a,d   Kryscio, R ^b   Kapali, M ^a   Armstrong, D K ^c   Deloia, Julie A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Precision Therapeutics Inc   (United States)

Author keywords

BRCA1; Ovarian carcinoma; Protein expression

Indexed keywords

BRCA1 PROTEIN; GENE PRODUCT;

ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE LOCATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEDICAL SOCIETY; OUTCOME ASSESSMENT; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE;

BRCA1 PROTEIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM STAGING; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; SURVIVAL ANALYSIS;

EID: 33645359491     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2006.00504.x     Document Type: Article

References (22)

1. Jemal A Murray T Ward E et al. Cancer Statistics, 2005. CA Cancer J Clin 2005 55 10 30.
2. Takahashi H Behbakht K McGovern PE et al. Mutation analysis of the BRCA1 gene in ovarian cancers. Cancer Res 1995 55 2998 3002.
3. Boyd J Rubin SC. Hereditary ovarian cancer: molecular genetics and clinical implications. Gynecol Oncol 1997 64 196 206.
4. Li AJ Karlan BY. Genetic factors in ovarian carcinoma. Curr Oncol Rep 2001 3 27 32.
5. Smith SA Richards WE Caito K et al. BRCA1 germline mutations and polymorphisms in a clinic-based series of ovarian cancer cases: a Gynecologic Oncology Group study. Gynecol Oncol 2001 83 586 92.
6. Berchuck A Heron KA Carney ME et al. Frequency of germline and somatic BRCA1 mutations in ovarian cancer. Clin Cancer Res 1998 4 2433 7.
7. Merajver SD Pham TM Caduff RF et al. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. Nat Genet 1995 9 439 43.
8. Baldwin RL Nemeth E Tran H et al. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 2000 60 5329 33.
9. Geisler JP Hatterman-Zogg MA Rathe JA Buller RE. Frequency of BRCA1 dysfunction in ovarian cancer. J Natl Cancer Inst 2002 94 61 7.
10. Wilson CA Ramos L Villasenor MR et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999 21 236 40.
11. Zheng W Luo F Lu JJ et al. Reduction of BRCA1 expression in sporadic ovarian cancer. Gynecol Oncol 2000 76 294 300.
12. Russell PA Pharoah PD De Foy K et al. Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers. Int J Cancer 2000 87 317 21.
13. Wang C. Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene. J Pathol 2004 202 215 23.
14. Jazaeri AA Yee CJ Sotiriou C Brantley KR Boyd J Liu ET. Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers. J Natl Cancer Inst 2002 94 990 1000.
15. Majdak EJ Debniak J Milscak T et al. Prognostic impact of BRCA1 pathogenic and BRCA1/2 unclassified variant mutations in patients with ovarian cancer. Cancer 2005 104 1004 12.
16. De Potter CR Coene ED Schelfhout VR. Localization of BRCA1 protein at the cellular level. J Mammary Gland Biol Neoplasia 1998 3 423 9.
17. Chen Y. Aberrant subcellular localization of BRCA1 in breast cancer. Science 1995 270 789 91.
18. Khoo US Ozcelik H Cheung AN et al. Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer. Oncogene 1999 18 4643 6.
19. Russell SE Hickey GI Lowry WS White P Atkinson RJ. Allele loss from chromosome 17 in ovarian cancer. Oncogene 1990 5 1581 3.
20. Tangir J Muto MG Berkowitz RS Welch WR Bell DA Mok SC. A 400 kb novel deletion unit centromeric to the BRCA1 gene in sporadic epithelial ovarian cancer. Oncogene 1996 12 735 40.
21. Catteau A Morris JR. BRCA1 methylation: a significant role in tumour development?. Semin Cancer Biol 2002 12 359 71.
22. Wilcox CS Baysal BE Gallion HH Strange MA DeLoia JA. High-resolution methylation analysis of the BRCA1 promoter in ovarian tumors. Cancer Genet Cytogenet 2005 159 114 22.