A high density linkage disequilibrium mapping in 14 noradrenergic genes: Evidence of association between SLC6A2, ADRA1B and ADHD

Psychopharmacology

Volumn 225, Issue 4, 2013, Pages 895-902

  Hawi, Ziarih ^a,f   Matthews, Natasha ^a   Barry, Edwina ^b   Kirley, Aiveen ^c   Wagner, Joseph ^a   Wallace, Robyn H ^a   Heussler, Helen S ^d   Vance, Alasdair ^e   Gill, Michael ^b   Bellgrove, Mark A ^a,f  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c St John of God Hospitaller Services Ireland   (Ireland)

^d MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f MONASH UNIVERSITY   (Australia)

Author keywords

ADHD; Association; Haplotype; Noradrenergic genes; SNP

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR;

ADRA1A GENE; ADRA1B GENE; ADRA2B GENE; ARTICLE; ATTENTION DEFICIT DISORDER; AUSTRALIA; CHILD; CONTROLLED STUDY; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; IRELAND; MAJOR CLINICAL STUDY; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SLC6A2 GENE;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHROMOSOME MAPPING; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 84873721640     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2875-x     Document Type: Article

References (32)

1. Albayrak O, Friedel S, Schimmelmann BG, Hinney A, Hebebrand J, J Neural Transm (2008) Genetic aspects in attention-deficit hyperactivity disorder. J Neural Transm 15(2):305-315, Review
2. Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M (1995) The child and adolescent psychiatric assessment (CAPA). Psychol Med 25(4):739-753
3. Amara S, Kuhar M (1993) Neurotransmitter transporters: recent progress. Ann Rev Neurosci 16:73-93
4. Aston-Jones G, Rajkowski J, Cohen J (1999) Role of locus coeruleus in attention and behavioral flexibility. Biol Psychiatry 46(9):1309-1320
5. Barr CL, Kroft J, Feng Y, Wigg K, Roberts W, Malone M, Ickowicz A, Schachar R, Tannock R, Kennedy JL (2002) The norepinephrine transporter gene and attention-deficit hyperactivity disorder. Am J Med Genet (Neuropsychiatr Genet) 114(3):255-259
6. Biederman J, Heiligenstein JH, Faries DE, Galil N, Dittmann R, Emslie GJ, Kratochvil CJ, Laws HF, Schuh KJ, Atomoxetine ADHD Study Group (2002) Efficacy of atomoxetine versus placebo in school-age girls with attention-deficit/ hyperactivity disorder. Pediatrics 110(6):75
7. Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK, Clasen LS, Sharp WS, Inoff-Germain G, Wavrant-De Vrièze F, Arcos-Burgos M, Straub RE, Hardy JA, Castellanos X, Rapoport JL (2005) Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet B (Neuropsychiatr Genet) 134B(1):67-72
8. Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Aneey R, Franke B, Gill M, Ebstein R et al (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934-953
9. Caballero J, Nahata MC (2003) Atomoxetine hydrochloride for the treatment of attention-deficit/hyperactivity disorder. Clin Ther 25(12):3065-3083
10. Comings DE, Gade-Andavolu R, Gonzalez N, Blake H, Wu S, MacMurray JP (1999) Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 55(3):160-172
11. Daly G, Hawi Z, Fitzgerald M, Gill M (1999) Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry M 4(2):192-196
12. Davids E, Zhang K, Kula NS, Tarazi FI, Baldessarini RJ (2002) Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats. J Pharmacol Exp Ther 301(3):1097-1102
13. De Luca V, Muglia P, Jain U, Kennedy JL (2004) No evidence of linkage or association between the norepinephrine transporter (NET) gene MnlI polymorphism and adult ADHD. Am J Med Genet (Neuropsychiatr Genet) 124B(1):38-40
14. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (2002) Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. J Neurosci 22(7):2873-2884
15. Eisenberg J, Mei-Tal G, Steinberg A, Tartakovsky E, Zohar A, Gritsenko I, Nemanov L, Ebstein RP (1999) Haplotype relative risk study of COMT and attention deficit hyperactivity disorder (ADHD), association of the high-enzyme activity Val allele with ADHD impulsive hyperactive phenotype. Am J Med Genet 88(5):497-502
16. Faraone SV, Biederman J (2002) Pathophysiology of attention deficit hyperactivity disorder. In: Davis K, Charney D, Coyle JT, Nemeroff C (eds) ACNP's fifth generation of progress - version 2. Lippincott Williams and Wilkins, New York
17. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296(5576):2225-2229
18. Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG (1999) Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 83(5400):397-401
19. Giros B, Jaber M, Jones S, Wightman RM, Caron M (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612
20. Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51-90
21. Lasky-Su J, Neale BM, Franke B, Anney RJ, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J et al (2008) Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B (Neuropsychiatr Genet) 147B(8):1345-1354
22. Manor I, Tyano S, Mel E, Eisenberg J, Bachner-Melman R, Kotler M, Ebstein RP (2002) Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA). Mol Psychiatry 7(6):626-632
23. McEvoy B, Hawi Z, Fitzgerald M, Gill M (2002) No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population. Am J Med Genet (Neuropsychiatr Genet) 114(6):665-666
24. Mick E, Todorov A, Smalley S, Hu X, Loo S, Todd RD, Biederman J, Byrne D, Dechairo B, Guiney A, McCracken J, McGough J, Nelson SF, Reiersen AM, Wilens TE, Wozniak J, Neale BM, Faraone SV (2010) Family-based genome-wide association scan of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49(9):898-905
25. Popper CW (2000) Pharmacologic alternatives to psychostimulants for the treatment of ADHD. Child Adolesc Psychiatr Clin N Am 9(3):605-646, Viii
26. Ramoz N, Boni C, Downing AM, Close SL, Peters SL, Prokop AM, Allen AJ, Hamon M, Purper-Ouakil D, Gorwood P (2009) A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology 34(9):2135-2142
27. Russell VA (2000) The nucleus accumbens motor-limbic interface of the spontaneously hypertensive rat as studied in vitro by the superfusion slice technique. Neurosci Biobehav Rev 24(1):133-136
28. Silverman WK, Albano AM (1996) The anxiety disorders interview schedule for children for DSM-IV (child and parent version). TX Psychological Corporation, San Antonio
29. Smith A, Nutt D (1996) Noradrenaline and attention lapses. Nature 380(6572):291
30. Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N, Taylor E, Casey BJ, Castellanos FX, Wadhwa PD (2007) Etiologic subtypes of ADHD: brain imaging, molecular genetics and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39-59
31. Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, Taylor E, Asherson P (2005) DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet 134B(1):115-118
32. Yang L, Wang YF, Li J, Faraone SV (2004) Association of norepinephrine transporter gene with methylphenidate response. J Am Acad Child Adolesc Psychiatry 43:1154-1158