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Volumn 104, Issue 2, 2013, Pages 178-184

Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ATM PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; ETOPOSIDE; GYRASE INHIBITOR; MIXED LINEAGE LEUKEMIA PROTEIN; SERINE;

EID: 84873721257     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12067     Document Type: Article
Times cited : (15)

References (54)
  • 1
    • 0030482567 scopus 로고    scopus 로고
    • Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer
    • Athma P, Rappaport R, Swift M. Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer. Cancer Genet Cytogenet 1996; 92: 130-4.
    • (1996) Cancer Genet Cytogenet , vol.92 , pp. 130-134
    • Athma, P.1    Rappaport, R.2    Swift, M.3
  • 2
    • 0033911566 scopus 로고    scopus 로고
    • ATM-heterozygous germline mutations contribute to breast cancer-susceptibility
    • Broeks A, Urbanus JH, Floore AN et al. ATM-heterozygous germline mutations contribute to breast cancer-susceptibility. Am J Hum Genet 2000; 66: 494-500.
    • (2000) Am J Hum Genet , vol.66 , pp. 494-500
    • Broeks, A.1    Urbanus, J.H.2    Floore, A.N.3
  • 3
    • 0035253615 scopus 로고    scopus 로고
    • ATM and ATR: networking cellular responses to DNA damage
    • Shiloh Y. ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev 2001; 11: 71-7.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 71-77
    • Shiloh, Y.1
  • 4
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000; 1: 179-86.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 6
    • 0035866811 scopus 로고    scopus 로고
    • Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion
    • Alexander FE, Patheal SL, Biondi A et al. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res 2001; 61: 2542-6.
    • (2001) Cancer Res , vol.61 , pp. 2542-2546
    • Alexander, F.E.1    Patheal, S.L.2    Biondi, A.3
  • 8
    • 0028775357 scopus 로고
    • Infant leukemia, topoisomerase II inhibitors, and the MLL gene
    • Ross JA, Potter JD, Robison LL. Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 1994; 86: 1678-80.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1678-1680
    • Ross, J.A.1    Potter, J.D.2    Robison, L.L.3
  • 9
    • 0029910797 scopus 로고    scopus 로고
    • Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group
    • Ross JA, Potter JD, Reaman GH, Pendergrass TW, Robison LL. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. Cancer Causes Control 1996; 7: 581-90.
    • (1996) Cancer Causes Control , vol.7 , pp. 581-590
    • Ross, J.A.1    Potter, J.D.2    Reaman, G.H.3    Pendergrass, T.W.4    Robison, L.L.5
  • 10
    • 0030041634 scopus 로고    scopus 로고
    • Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites
    • Broeker PL, Super HG, Thirman MJ et al. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 1996; 87: 1912-22.
    • (1996) Blood , vol.87 , pp. 1912-1922
    • Broeker, P.L.1    Super, H.G.2    Thirman, M.J.3
  • 11
    • 0037528708 scopus 로고    scopus 로고
    • Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement
    • Oguchi K, Takagi M, Tsuchida R et al. Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement. Blood 2003; 101: 3622-7.
    • (2003) Blood , vol.101 , pp. 3622-3627
    • Oguchi, K.1    Takagi, M.2    Tsuchida, R.3
  • 12
    • 0030797708 scopus 로고    scopus 로고
    • Recombinant ATM protein complements the cellular A-T phenotype
    • Ziv Y, Bar-Shira A, Pecker I et al. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 1997; 15: 159-67.
    • (1997) Oncogene , vol.15 , pp. 159-167
    • Ziv, Y.1    Bar-Shira, A.2    Pecker, I.3
  • 13
    • 9444229370 scopus 로고    scopus 로고
    • Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line
    • Carpenter AJ, Porter AC. Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line. Mol Biol Cell 2004; 15: 5700-11.
    • (2004) Mol Biol Cell , vol.15 , pp. 5700-5711
    • Carpenter, A.J.1    Porter, A.C.2
  • 14
    • 19944427410 scopus 로고    scopus 로고
    • Diagnostic tool for the identification of MLL rearrangements including unknown partner genes
    • Meyer C, Schneider B, Reichel M et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005; 102: 449-54.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 449-454
    • Meyer, C.1    Schneider, B.2    Reichel, M.3
  • 15
    • 1342289580 scopus 로고    scopus 로고
    • Etoposide induces chimeric Mll gene fusions
    • Blanco JG, Edick MJ, Relling MV. Etoposide induces chimeric Mll gene fusions. FASEB J 2004; 18: 173-5.
    • (2004) FASEB J , vol.18 , pp. 173-175
    • Blanco, J.G.1    Edick, M.J.2    Relling, M.V.3
  • 16
    • 0035837039 scopus 로고    scopus 로고
    • Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells
    • Kobayashi M, Adachi N, Aratani Y, Kikuchi A, Koyama H. Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells. Cancer Lett 2001; 166: 71-7.
    • (2001) Cancer Lett , vol.166 , pp. 71-77
    • Kobayashi, M.1    Adachi, N.2    Aratani, Y.3    Kikuchi, A.4    Koyama, H.5
  • 17
    • 0029982520 scopus 로고    scopus 로고
    • Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide
    • Asano T, An T, Zwelling LA, Takano H, Fojo AT, Kleinerman ES. Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide. Oncol Res 1996; 8: 101-10.
    • (1996) Oncol Res , vol.8 , pp. 101-110
    • Asano, T.1    An, T.2    Zwelling, L.A.3    Takano, H.4    Fojo, A.T.5    Kleinerman, E.S.6
  • 18
    • 0033568541 scopus 로고    scopus 로고
    • Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells
    • Zhou Z, Zwelling LA, Kawakami Y et al. Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells. Cancer Res 1999; 59: 4618-24.
    • (1999) Cancer Res , vol.59 , pp. 4618-4624
    • Zhou, Z.1    Zwelling, L.A.2    Kawakami, Y.3
  • 19
    • 77953557271 scopus 로고    scopus 로고
    • Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM
    • Bower JJ, Zhou Y, Zhou T et al. Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM. Cell Cycle 2010; 9: 1617-28.
    • (2010) Cell Cycle , vol.9 , pp. 1617-1628
    • Bower, J.J.1    Zhou, Y.2    Zhou, T.3
  • 20
    • 0027496657 scopus 로고
    • Hypersensitivity of lymphoblastoid lines derived from ataxia telangiectasia patients to the induction of chromosomal aberrations by etoposide (VP-16)
    • Caporossi D, Porfirio B, Nicoletti B et al. Hypersensitivity of lymphoblastoid lines derived from ataxia telangiectasia patients to the induction of chromosomal aberrations by etoposide (VP-16). Mutat Res 1993; 290: 265-72.
    • (1993) Mutat Res , vol.290 , pp. 265-272
    • Caporossi, D.1    Porfirio, B.2    Nicoletti, B.3
  • 21
    • 0029878426 scopus 로고    scopus 로고
    • VP16 hypersensitivity and increased faulty recombination in ataxia telangiectasia lymphocytes characterized by the tandem translocation t(14;14)(q11;q32)
    • Petrinelli P, Elli R, Marcucci L, Barbieri C, Ambra R, Antonelli A. VP16 hypersensitivity and increased faulty recombination in ataxia telangiectasia lymphocytes characterized by the tandem translocation t(14;14)(q11;q32). Carcinogenesis 1996; 17: 203-7.
    • (1996) Carcinogenesis , vol.17 , pp. 203-207
    • Petrinelli, P.1    Elli, R.2    Marcucci, L.3    Barbieri, C.4    Ambra, R.5    Antonelli, A.6
  • 22
    • 0024592308 scopus 로고
    • Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line
    • Smith PJ, Makinson TA. Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line. Cancer Res 1989; 49: 1118-24.
    • (1989) Cancer Res , vol.49 , pp. 1118-1124
    • Smith, P.J.1    Makinson, T.A.2
  • 23
    • 0025817295 scopus 로고
    • Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes
    • Kaufmann WK, Boyer JC, Estabrooks LL, Wilson SJ. Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes. Mol Cell Biol 1991; 11: 3711-8.
    • (1991) Mol Cell Biol , vol.11 , pp. 3711-3718
    • Kaufmann, W.K.1    Boyer, J.C.2    Estabrooks, L.L.3    Wilson, S.J.4
  • 24
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 25
  • 26
    • 0024410960 scopus 로고
    • Study of DNA topoisomerase II in ataxia-telangiectasia cells
    • Singh SP, Lavin MF. Study of DNA topoisomerase II in ataxia-telangiectasia cells. Carcinogenesis 1989; 10: 1215-8.
    • (1989) Carcinogenesis , vol.10 , pp. 1215-1218
    • Singh, S.P.1    Lavin, M.F.2
  • 27
    • 0025655911 scopus 로고
    • Defective DNA topoisomerase II in ataxia-telangiectasia cells
    • Lavin MF, Singh SP. Defective DNA topoisomerase II in ataxia-telangiectasia cells. Acta Biol Hung 1990; 41: 125-35.
    • (1990) Acta Biol Hung , vol.41 , pp. 125-135
    • Lavin, M.F.1    Singh, S.P.2
  • 28
    • 0024536961 scopus 로고
    • Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant
    • Davies SM, Harris AL, Hickson ID. Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant. Nucleic Acids Res 1989; 17: 1337-51.
    • (1989) Nucleic Acids Res , vol.17 , pp. 1337-1351
    • Davies, S.M.1    Harris, A.L.2    Hickson, I.D.3
  • 30
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000; 14: 927-39.
    • (2000) Genes Dev , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 31
    • 0033575865 scopus 로고    scopus 로고
    • Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA
    • Yamane K, Tsuruo T. Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene 1999; 18: 5194-203.
    • (1999) Oncogene , vol.18 , pp. 5194-5203
    • Yamane, K.1    Tsuruo, T.2
  • 32
    • 0036134979 scopus 로고    scopus 로고
    • A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
    • Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 2002; 22: 555-66.
    • (2002) Mol Cell Biol , vol.22 , pp. 555-566
    • Yamane, K.1    Wu, X.2    Chen, J.3
  • 33
    • 0034711877 scopus 로고    scopus 로고
    • Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53
    • Cowell IG, Okorokov AL, Cutts SA et al. Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53. Exp Cell Res 2000; 255: 86-94.
    • (2000) Exp Cell Res , vol.255 , pp. 86-94
    • Cowell, I.G.1    Okorokov, A.L.2    Cutts, S.A.3
  • 34
    • 0028114974 scopus 로고
    • Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro
    • Wells NJ, Addison CM, Fry AM, Ganapathi R, Hickson ID. Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro. J Biol Chem 1994; 269: 29746-51.
    • (1994) J Biol Chem , vol.269 , pp. 29746-29751
    • Wells, N.J.1    Addison, C.M.2    Fry, A.M.3    Ganapathi, R.4    Hickson, I.D.5
  • 35
    • 0028784314 scopus 로고
    • Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C
    • Wells NJ, Fry AM, Guano F, Norbury C, Hickson ID. Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C. J Biol Chem 1995; 270: 28357-63.
    • (1995) J Biol Chem , vol.270 , pp. 28357-28363
    • Wells, N.J.1    Fry, A.M.2    Guano, F.3    Norbury, C.4    Hickson, I.D.5
  • 36
    • 0029973553 scopus 로고    scopus 로고
    • Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle
    • Ishida R, Iwai M, Marsh KL et al. Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle. J Biol Chem 1996; 271: 30077-82.
    • (1996) J Biol Chem , vol.271 , pp. 30077-30082
    • Ishida, R.1    Iwai, M.2    Marsh, K.L.3
  • 37
    • 0034602177 scopus 로고    scopus 로고
    • Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469
    • Escargueil AE, Plisov SY, Filhol O, Cochet C, Larsen AK. Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469. J Biol Chem 2000; 275: 34710-8.
    • (2000) J Biol Chem , vol.275 , pp. 34710-34718
    • Escargueil, A.E.1    Plisov, S.Y.2    Filhol, O.3    Cochet, C.4    Larsen, A.K.5
  • 38
    • 0028980932 scopus 로고
    • Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase
    • Wells NJ, Hickson ID. Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase. Eur J Biochem 1995; 231: 491-7.
    • (1995) Eur J Biochem , vol.231 , pp. 491-497
    • Wells, N.J.1    Hickson, I.D.2
  • 39
    • 0032961902 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation
    • Shapiro PS, Whalen AM, Tolwinski NS et al. Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Mol Cell Biol 1999; 19: 3551-60.
    • (1999) Mol Cell Biol , vol.19 , pp. 3551-3560
    • Shapiro, P.S.1    Whalen, A.M.2    Tolwinski, N.S.3
  • 40
    • 78649938817 scopus 로고    scopus 로고
    • ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
    • Bensimon A, Schmidt A, Ziv Y et al. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal 2010; 3: rs3.
    • (2010) Sci Signal , vol.3
    • Bensimon, A.1    Schmidt, A.2    Ziv, Y.3
  • 41
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim ST, Lim DS, Canman CE, Kastan MB. Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 1999; 274: 37538-43.
    • (1999) J Biol Chem , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 42
    • 0028060322 scopus 로고
    • Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells
    • Watanabe F, Teraoka H, Iijima S, Mimori T, Tsukada K. Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells. Biochim Biophys Acta 1994; 1223: 255-60.
    • (1994) Biochim Biophys Acta , vol.1223 , pp. 255-260
    • Watanabe, F.1    Teraoka, H.2    Iijima, S.3    Mimori, T.4    Tsukada, K.5
  • 43
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999; 286: 1162-6.
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 44
    • 0034753633 scopus 로고    scopus 로고
    • Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines
    • Matsumoto Y, Takano H, Kunishio K, Nagao S, Fojo T. Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res 2001; 92: 1133-7.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 1133-1137
    • Matsumoto, Y.1    Takano, H.2    Kunishio, K.3    Nagao, S.4    Fojo, T.5
  • 45
    • 0028091270 scopus 로고
    • Altered subcellular distribution of topoisomerase II alpha in a drug-resistant human small cell lung cancer cell line
    • Feldhoff PW, Mirski SE, Cole SP, Sullivan DM. Altered subcellular distribution of topoisomerase II alpha in a drug-resistant human small cell lung cancer cell line. Cancer Res 1994; 54: 756-62.
    • (1994) Cancer Res , vol.54 , pp. 756-762
    • Feldhoff, P.W.1    Mirski, S.E.2    Cole, S.P.3    Sullivan, D.M.4
  • 46
    • 0030774826 scopus 로고    scopus 로고
    • Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization
    • Wessel I, Jensen PB, Falck J, Mirski SE, Cole SP, Sehested M. Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization. Cancer Res 1997; 57: 4451-4.
    • (1997) Cancer Res , vol.57 , pp. 4451-4454
    • Wessel, I.1    Jensen, P.B.2    Falck, J.3    Mirski, S.E.4    Cole, S.P.5    Sehested, M.6
  • 47
    • 0034667463 scopus 로고    scopus 로고
    • Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors
    • Oloumi A, MacPhail SH, Johnston PJ, Banath JP, Olive PL. Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors. Cancer Res 2000; 60: 5747-53.
    • (2000) Cancer Res , vol.60 , pp. 5747-5753
    • Oloumi, A.1    MacPhail, S.H.2    Johnston, P.J.3    Banath, J.P.4    Olive, P.L.5
  • 48
    • 0027444178 scopus 로고
    • Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line
    • Chan VT, Ng SW, Eder JP, Schnipper LE. Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line. J Biol Chem 1993; 268: 2160-5.
    • (1993) J Biol Chem , vol.268 , pp. 2160-2165
    • Chan, V.T.1    Ng, S.W.2    Eder, J.P.3    Schnipper, L.E.4
  • 49
    • 0034079789 scopus 로고    scopus 로고
    • Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells
    • Patel S, Keller BA, Fisher LM. Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells. Mol Pharmacol 2000; 57: 784-91.
    • (2000) Mol Pharmacol , vol.57 , pp. 784-791
    • Patel, S.1    Keller, B.A.2    Fisher, L.M.3
  • 50
    • 0026526176 scopus 로고
    • Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II
    • Lee MS, Wang JC, Beran M. Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II. J Mol Biol 1992; 223: 837-43.
    • (1992) J Mol Biol , vol.223 , pp. 837-843
    • Lee, M.S.1    Wang, J.C.2    Beran, M.3
  • 51
    • 0033578339 scopus 로고    scopus 로고
    • Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity
    • Mao Y, Yu C, Hsieh TS et al. Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. Biochemistry 1999; 38: 10793-800.
    • (1999) Biochemistry , vol.38 , pp. 10793-10800
    • Mao, Y.1    Yu, C.2    Hsieh, T.S.3
  • 52
    • 0025997529 scopus 로고
    • Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines
    • Long BH, Wang L, Lorico A, Wang RC, Brattain MG, Casazza AM. Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines. Cancer Res 1991; 51: 5275-83.
    • (1991) Cancer Res , vol.51 , pp. 5275-5283
    • Long, B.H.1    Wang, L.2    Lorico, A.3    Wang, R.C.4    Brattain, M.G.5    Casazza, A.M.6
  • 53
    • 0029006931 scopus 로고
    • Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line
    • Mirski SE, Cole SP. Cytoplasmic localization of a mutant M(r) 160, 000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line. Cancer Res 1995; 55: 2129-34.
    • (1995) Cancer Res , vol.55 , pp. 2129-2134
    • Mirski, S.E.1    Cole, S.P.2
  • 54
    • 31044441712 scopus 로고    scopus 로고
    • Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
    • Nakada S, Katsuki Y, Imoto I et al. Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. J Clin Invest 2006; 116: 80-9.
    • (2006) J Clin Invest , vol.116 , pp. 80-89
    • Nakada, S.1    Katsuki, Y.2    Imoto, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.