Decreased topoisomerase IIα expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells

Cancer Letters

Volumn 166, Issue 1, 2001, Pages 71-77

  Kobayashi, Masao ^a   Adachi, Noritaka ^a   Aratani, Yasuaki ^a   Kikuchi, Akihiko ^b   Koyama, Hideki ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Drug resistance; Embryonic stem cell; Gene targeting; Topoisomerase II; Topoisomerase II inhibitor

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; DNA TOPOISOMERASE; DNA TOPOISOMERASE 2ALPHA; DNA TOPOISOMERASE 2BETA; ETOPOSIDE; POISON; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; ENZYME INHIBITOR; ISOENZYME; MESSENGER RNA; PIPERAZINE DERIVATIVE; TUMOR ANTIGEN;

ANIMAL CELL; ARTICLE; CARCINOMA; CELL MUTANT; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; EMBRYO CELL; GENE TARGETING; HETEROZYGOSITY; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; ANIMAL; BIOSYNTHESIS; CELL LINE; CLONOGENIC ASSAY; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; EMBRYO; GENETICS; HETEROZYGOTE;

MAMMALIA;

ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CELL LINE; COLONY-FORMING UNITS ASSAY; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DOWN-REGULATION; DRUG RESISTANCE; EMBRYO; ENZYME INHIBITORS; ETOPOSIDE; GENE TARGETING; HETEROZYGOTE; ISOENZYMES; MICE; PIPERAZINES; RNA, MESSENGER; STEM CELLS;

EID: 0035837039     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00447-5     Document Type: Article

References (21)

1. Antitopoisomerase drug action and resistance
2. DNA topoisomerase poisons as antitumor drugs
3. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
4. Catalytic inhibitors of DNA topoisomerase II
5. Expression of a multidrug-resistance gene in human tumors and tissues
6. Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance
7. Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line
8. Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines
9. DNA topoisomerase IIα gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells
10. Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors
11. Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II
12. DNA topoisomerase II is the molecular target of bisdioxopiperazeine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae
13. Yeast cells expressing differential levels of human or yeast DNA topoisomerase II: A potent tool for identification and characterization of topoisomerase II-targeting antitumour agents
14. Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation
15. Structural organization of the human TOP2A and TOP2B genes
16. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase
17. Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells
18. Characterization of the 3′ untranslated region of mouse DNA topoisomerase IIα mRNA
19. Mutant isolation of mouse DNA topoisomerase IIα in yeast
20. Production of homozygous mutant ES cells with a single targeting construct
21. A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines