Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1159-1165

  Tanaka, Minoru ^a   Li, Xin ^a   Hikawa, Hidemasa ^a   Suzuki, Takafumi ^a   Tsutsumi, Katsuhiko ^a   Sato, Masashi ^a   Takikawa, Osamu ^b   Suzuki, Hideharu ^a   Yokoyama, Yuusaku ^a  

^a TOHO UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Biomimetic synthesis; IDO; Indoleamine 2,3 dioxygenase; Tryptoline derivatives; Tryptophan

Indexed keywords

10 BROMO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 10 CHLORO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 10 PHENYL 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1'5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 7 BROMO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 7 CHLORO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 7 PHENYL 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1'5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 8 BROMO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 8 CHLORO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 8 PHENYL 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1'5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 9 CHLORO 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 9 PHENYL 2,5 DIMETHYL 1 OXO 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1'5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 9,11 DIMETHYL 10 THIOXO 7,7A,9,10,11,12 HEXAHYDRO 9,10A 12 TRIAZA BENZO[A]CYCLOPENTA[H]FLUOREN 8 ONE; 9,11 DIMETHYL 10 THIOXO 7,7A,9,10,11,12 HEXAHYDRO 9,10A 12 TRIAZA BENZO[B]CYCLOPENTA[H]FLUOREN 8 ONE; 9,11 DIMETHYL 10 THIOXO 7,7A,9,10,11,12 HEXAHYDRO 9,10A 12 TRIAZA BENZO[C]CYCLOPENTA[H]FLUOREN 8 ONE; BENZENEBORONIC ACID; ENZYME INHIBITOR; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; METHYLTHIOHYDANTOIN TRYPTOPHAN; TRYPTOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ENZYME ASSAY; ENZYME INHIBITION; IC 50; SUBSTITUTION REACTION; SUZUKI REACTION;

CARBOLINES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; PROTEIN BINDING; STEREOISOMERISM; TRYPTOPHAN;

EID: 84873716461     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.028     Document Type: Article

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