Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation

Cellular and Molecular Life Sciences

Volumn 70, Issue 5, 2013, Pages 909-922

  De Clercq, Sarah ^a,b   Zwaenepoel, Olivier ^a,b   Martens, Evelien ^a,b   Vandekerckhove, Joël ^a,b   Guillabert, Aude ^a,b   Gettemans, Jan ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Immune synapse; Integrin; L plastin; LFA 1; Nanobody

Indexed keywords

ACTIN BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 2; L PLASTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NANOBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; LYMPHOCYTE PROLIFERATION; MICROTUBULE ORGANIZING CENTER; MOLECULAR DOCKING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; T LYMPHOCYTE ACTIVATION;

ACTINS; ANIMALS; ANTIGEN-PRESENTING CELLS; CALMODULIN; CELL COMMUNICATION; CELL LINE; CELLS, CULTURED; EF HAND MOTIFS; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE GLYCOPROTEINS; MICROFILAMENT PROTEINS; MICROTUBULE-ORGANIZING CENTER; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; SINGLE-DOMAIN ANTIBODIES; T-LYMPHOCYTES;

CAMELIDAE;

EID: 84873714224     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1169-0     Document Type: Article

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