메뉴 건너뛰기




Volumn 14, Issue 1, 2013, Pages 109-126

Novel therapies for the treatment of advanced prostate cancer

Author keywords

Androgen receptor; Androgen synthesis inhibitors; Castration resistant; Epigenetic; Epithelial mesenchymal transition; Immunotherapies; Metastatic; Novel; PI3 kinase inhibitors; Prostate cancer; Treatments

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ABIRATERONE; AFLIBERCEPT; AZACITIDINE; BEVACIZUMAB; BICALUTAMIDE; BUPARLISIB; CABAZITAXEL; CABOZANTINIB; CIXUTUMUMAB; CUSTIRSEN; DASATINIB; DOCETAXEL; ENZALUTAMIDE; GALETERONE; IPILIMUMAB; MITOXANTRONE; NIVOLUMAB; OLAPARIB; ORTERONEL; PANOBINOSTAT; PLACEBO; PREDNISONE; RILIMOGENE GALVACIREPVEC; SIPULEUCEL T; TASQUINIMOD; TIVANTINIB; UNINDEXED DRUG; VISMODEGIB; VORINOSTAT;

EID: 84873713208     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-012-0222-4     Document Type: Article
Times cited : (19)

References (94)
  • 1
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • 22722839 10.1038/nature11125 1:CAS:528:DC%2BC38XhtVWisLfP Characterizes common mutations found in exomes of prostate cancer
    • Grasso CS, Wu YM, Robinson DR, et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012;487:239-43. Characterizes common mutations found in exomes of prostate cancer.
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1    Wu, Y.M.2    Robinson, D.R.3
  • 2
    • 84856530618 scopus 로고    scopus 로고
    • Common structural and epigenetic changes in the genome of castration-resistant prostate cancer
    • 22158653 10.1158/0008-5472.CAN-11-2079 1:CAS:528:DC%2BC38XhslCjsbo%3D Describes comprehensive gene methylation and copy number alterations in prostate cancer
    • Friedlander TW, Roy R, Tomlins SA, et al. Common structural and epigenetic changes in the genome of castration-resistant prostate cancer. Cancer Res. 2012;72:616-25. Describes comprehensive gene methylation and copy number alterations in prostate cancer.
    • (2012) Cancer Res , vol.72 , pp. 616-625
    • Friedlander, T.W.1    Roy, R.2    Tomlins, S.A.3
  • 3
    • 77954255681 scopus 로고    scopus 로고
    • Integrative genomic profiling of human prostate cancer
    • 20579941 10.1016/j.ccr.2010.05.026 1:CAS:528:DC%2BC3cXpslSjt7s%3D Defines the prostate cancer transcriptome and profile copy number alteration involved in many oncogenic pathways
    • Taylor BS, Schultz N, Hieronymus H, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell. 2010;18:11-22. Defines the prostate cancer transcriptome and profile copy number alteration involved in many oncogenic pathways.
    • (2010) Cancer Cell , vol.18 , pp. 11-22
    • Taylor, B.S.1    Schultz, N.2    Hieronymus, H.3
  • 4
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • 20818862 10.1056/NEJMoa1001294 1:CAS:528:DC%2BC3cXhtVGlurrN
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-22.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 5
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
    • 20888992 10.1016/S0140-6736(10)61389-X
    • de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376:1147-54.
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 6
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • 21612468 10.1056/NEJMoa1014618
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005.
    • (2011) N Engl J Med , vol.364 , pp. 1995-2005
    • De Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 7
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • 21353695 10.1016/S0140-6736(10)62344-6 1:CAS:528:DC%2BC3MXjsVyrt70%3D
    • Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet. 2011;377:813-22.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 8
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapys
    • Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012.
    • (2012) N Engl J Med
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 10
    • 70349140531 scopus 로고    scopus 로고
    • Outcomes of localized prostate cancer following conservative management
    • 19755699 10.1001/jama.2009.1348 1:CAS:528:DC%2BD1MXhtFeltb7E
    • Lu-Yao GL, Albertsen PC, Moore DF, et al. Outcomes of localized prostate cancer following conservative management. JAMA. 2009;302:1202-9.
    • (2009) JAMA , vol.302 , pp. 1202-1209
    • Lu-Yao, G.L.1    Albertsen, P.C.2    Moore, D.F.3
  • 11
    • 0034603826 scopus 로고    scopus 로고
    • Single-therapy androgen suppression in men with advanced prostate cancer: A systematic review and meta-analysis
    • 10744594 1:CAS:528:DC%2BD3cXis1Sjsrs%3D
    • Seidenfeld J, Samson DJ, Hasselblad V, et al. Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. Ann Intern Med. 2000;132:566-77.
    • (2000) Ann Intern Med , vol.132 , pp. 566-577
    • Seidenfeld, J.1    Samson, D.J.2    Hasselblad, V.3
  • 12
    • 80053078529 scopus 로고    scopus 로고
    • Common gene rearrangements in prostate cancer
    • 21859993 10.1200/JCO.2011.35.1916 1:CAS:528:DC%2BC3MXhtlGrsLjP
    • Rubin MA, Maher CA, Chinnaiyan AM. Common gene rearrangements in prostate cancer. J Clin Oncol. 2011;29:3659-68.
    • (2011) J Clin Oncol , vol.29 , pp. 3659-3668
    • Rubin, M.A.1    Maher, C.A.2    Chinnaiyan, A.M.3
  • 13
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • 16254181 10.1126/science.1117679 1:CAS:528:DC%2BD2MXhtFChsLjJ
    • Tomlins SA, Rhodes DR, Perner S, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005;310:644-8.
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3
  • 14
    • 41149097040 scopus 로고    scopus 로고
    • A causal role for ERG in neoplastic transformation of prostate epithelium
    • 18245377 10.1073/pnas.0711711105
    • Klezovitch O, Risk M, Coleman I, et al. A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci USA. 2008;105:2105-10.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2105-2110
    • Klezovitch, O.1    Risk, M.2    Coleman, I.3
  • 15
    • 68049131467 scopus 로고    scopus 로고
    • Reactivation of androgen receptor-regulated TMPRSS2: ERG gene expression in castration-resistant prostate cancer
    • 19584279 10.1158/0008-5472.CAN-09-0395 1:CAS:528:DC%2BD1MXpt1Cgt7w%3D
    • Cai C, Wang H, Xu Y, Chen S, Balk SP. Reactivation of androgen receptor-regulated TMPRSS2: ERG gene expression in castration-resistant prostate cancer. Cancer Res. 2009;69:6027-32.
    • (2009) Cancer Res , vol.69 , pp. 6027-6032
    • Cai, C.1    Wang, H.2    Xu, Y.3    Chen, S.4    Balk, S.P.5
  • 16
    • 33749029695 scopus 로고    scopus 로고
    • TMPRSS2: ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer
    • 16951139 10.1158/0008-5472.CAN-06-1482 1:CAS:528:DC%2BD28XovF2jtbY%3D
    • Perner S, Demichelis F, Beroukhim R, et al. TMPRSS2: ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res. 2006;66:8337-41.
    • (2006) Cancer Res , vol.66 , pp. 8337-8341
    • Perner, S.1    Demichelis, F.2    Beroukhim, R.3
  • 17
    • 0842311632 scopus 로고    scopus 로고
    • The androgen axis in recurrent prostate cancer
    • 14760063 10.1158/1078-0432.CCR-1146-03 1:CAS:528:DC%2BD2cXovVGktA%3D%3D
    • Mohler JL, Gregory CW, Ford 3rd OH, et al. The androgen axis in recurrent prostate cancer. Clin Cancer Res. 2004;10:440-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 440-448
    • Mohler, J.L.1    Gregory, C.W.2    Ford III, O.H.3
  • 18
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • 14702632 10.1038/nm972
    • Chen CD, Welsbie DS, Tran C, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004;10:33-9.
    • (2004) Nat Med , vol.10 , pp. 33-39
    • Chen, C.D.1    Welsbie, D.S.2    Tran, C.3
  • 19
    • 68049137909 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT pathway for the treatment of prostate cancer
    • 19638457 10.1158/1078-0432.CCR-08-0125 1:CAS:528:DC%2BD1MXptl2gsLo%3D
    • Sarker D, Reid AH, Yap TA, de Bono JS. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res. 2009;15:4799-805.
    • (2009) Clin Cancer Res , vol.15 , pp. 4799-4805
    • Sarker, D.1    Reid, A.H.2    Yap, T.A.3    De Bono, J.S.4
  • 20
    • 84873731848 scopus 로고    scopus 로고
    • New and emerging therapies for bone metastases in genitourinary cancers
    • Saylor PJ, Armstrong AJ, Fizazi K, et al. New and emerging therapies for bone metastases in genitourinary cancers. Eur Urol 2012.
    • (2012) Eur Urol
    • Saylor, P.J.1    Armstrong, A.J.2    Fizazi, K.3
  • 21
    • 84866758890 scopus 로고    scopus 로고
    • Interim analysis (IA) results of COU-AA-302, a randomized, phase III study of abiraterone acetate (AA) in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
    • Ryan CJ, Smith MR, De Bono JS, et al. Interim analysis (IA) results of COU-AA-302, a randomized, phase III study of abiraterone acetate (AA) in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). ASCO Meeting Abstracts 2012;30:LBA4518.
    • (2012) ASCO Meeting Abstracts , vol.30
    • Ryan, C.J.1    Smith, M.R.2    De Bono, J.S.3
  • 22
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • 19359544 10.1126/science.1168175 1:CAS:528:DC%2BD1MXlsVeksro%3D
    • Tran C, Ouk S, Clegg NJ, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009;324:787-90.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3
  • 23
    • 84863230424 scopus 로고    scopus 로고
    • ARN-509: A novel antiandrogen for prostate cancer treatment
    • 22266222 10.1158/0008-5472.CAN-11-3948 1:CAS:528:DC%2BC38XktVanu74%3D
    • Clegg NJ, Wongvipat J, Joseph JD, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012;72:1494-503.
    • (2012) Cancer Res , vol.72 , pp. 1494-1503
    • Clegg, N.J.1    Wongvipat, J.2    Joseph, J.D.3
  • 24
    • 84873733677 scopus 로고    scopus 로고
    • Phase I/II safety and pharmacokinetic (PK) study of ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC): Phase i results of a Prostate Cancer Clinical Trials Consortium study
    • Rathkopf DE DD, Morris MJ, Slovin SF, Steinbrecher JE, Arauz G, Rix PJ, Maneval EC, Chen I, Fox JJ, Fleisher M, Larson SM, Scher HI. Phase I/II safety and pharmacokinetic (PK) study of ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC): Phase I results of a Prostate Cancer Clinical Trials Consortium study. J Clin Oncol 2012.
    • (2012) J Clin Oncol
    • De Dd, R.1    Morris, M.J.2    Slovin, S.F.3    Steinbrecher, J.E.4    Arauz, G.5    Rix, P.J.6    Maneval, E.C.7    Chen, I.8    Fox, J.J.9    Fleisher, M.10    Larson, S.M.11    Scher, H.I.12
  • 25
    • 84873712416 scopus 로고    scopus 로고
    • Abstract LBA25 September 30, 2012; 2012 European Society for Medical Oncology (ESMO) Congress
    • Abstract LBA25. In: 2012 European Society for Medical Oncology (ESMO) Congress Presented September 30, 2012; 2012 European Society for Medical Oncology (ESMO) Congress.
    • 2012 European Society for Medical Oncology (ESMO) Congress
  • 26
    • 77953280591 scopus 로고    scopus 로고
    • Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
    • 20541699 10.1016/j.ccr.2010.04.027 1:CAS:528:DC%2BC3cXot1Cgsb8%3D Novel mechanism of action in targeting the N-termainal domain of the AR
    • Andersen RJ, Mawji NR, Wang J, et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell. 2010;17:535-46. Novel mechanism of action in targeting the N-termainal domain of the AR.
    • (2010) Cancer Cell , vol.17 , pp. 535-546
    • Andersen, R.J.1    Mawji, N.R.2    Wang, J.3
  • 27
    • 79951825699 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity
    • 21285252 10.1158/0008-5472.CAN-10-3398 1:CAS:528:DC%2BC3MXhvFSjs7s%3D
    • Sadar MD. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res. 2011;71:1208-13.
    • (2011) Cancer Res , vol.71 , pp. 1208-1213
    • Sadar, M.D.1
  • 28
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • 22710436 10.1158/0008-5472.CAN-11-3892 1:CAS:528:DC%2BC38XhtVeltbzM
    • Hu R, Lu C, Mostaghel EA, et al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res. 2012;72:3457-62.
    • (2012) Cancer Res , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3
  • 29
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • 21807635 10.1158/1078-0432.CCR-11-0728 1:CAS:528:DC%2BC3MXhtFOitLfM
    • Mostaghel EA, Marck BT, Plymate SR, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res. 2011;17:5913-25.
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3
  • 30
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • 16510604 10.1158/0008-5472.CAN-05-4000 1:CAS:528:DC%2BD28XhvV2gt7Y%3D
    • Stanbrough M, Bubley GJ, Ross K, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 2006;66:2815-25.
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3
  • 31
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • 18519708 10.1158/0008-5472.CAN-08-0249 1:CAS:528:DC%2BD1cXmsFKlsr8%3D
    • Montgomery RB, Mostaghel EA, Vessella R, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008;68:4447-54.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3
  • 32
    • 84856780403 scopus 로고    scopus 로고
    • Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
    • 21978946 10.1016/j.bmc.2011.08.066 1:CAS:528:DC%2BC3MXhtlejsLrI
    • Kaku T, Hitaka T, Ojida A, et al. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorg Med Chem. 2011;19:6383-99.
    • (2011) Bioorg Med Chem , vol.19 , pp. 6383-6399
    • Kaku, T.1    Hitaka, T.2    Ojida, A.3
  • 33
    • 80054749674 scopus 로고    scopus 로고
    • Emerging therapeutic approaches in the management of metastatic castration-resistant prostate cancer
    • 21577233 10.1038/pcan.2011.24 1:CAS:528:DC%2BC3MXhtVWrt77M
    • Antonarakis ES, Armstrong AJ. Emerging therapeutic approaches in the management of metastatic castration-resistant prostate cancer. Prostate Cancer Prostatic Dis. 2011;14:206-18.
    • (2011) Prostate Cancer Prostatic Dis , vol.14 , pp. 206-218
    • Antonarakis, E.S.1    Armstrong, A.J.2
  • 34
    • 84871554943 scopus 로고    scopus 로고
    • Baseline serum adrenal androgens are prognostic and predictive of overall survival (OS) in patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC): Results of the COU-AA-301 phase 3 randomized trial
    • Abstract LB-434
    • Ryan C, Li J, Kheoh T, Scher HI, Molina A. Abstract LB-434: Baseline serum adrenal androgens are prognostic and predictive of overall survival (OS) in patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC): Results of the COU-AA-301 phase 3 randomized trial. Cancer Res 2012;72:LB-434.
    • (2012) Cancer Res , vol.2
    • Ryan, C.1    Li, J.2    Kheoh, T.3    Scher, H.I.4    Molina, A.5
  • 35
    • 80052705344 scopus 로고    scopus 로고
    • Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
    • 21729712 10.1016/j.steroids.2011.06.002 1:CAS:528:DC%2BC3MXhtFGgurbM
    • Bruno RD, Vasaitis TS, Gediya LK, et al. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model. Steroids. 2011;76:1268-79.
    • (2011) Steroids , vol.76 , pp. 1268-1279
    • Bruno, R.D.1    Vasaitis, T.S.2    Gediya, L.K.3
  • 37
    • 35948950583 scopus 로고    scopus 로고
    • Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity
    • 17974989 10.1158/0008-5472.CAN-07-2057 1:CAS:528:DC%2BD2sXht1erurrN
    • Zoubeidi A, Zardan A, Beraldi E, et al. Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Res. 2007;67:10455-65.
    • (2007) Cancer Res , vol.67 , pp. 10455-10465
    • Zoubeidi, A.1    Zardan, A.2    Beraldi, E.3
  • 38
    • 84873742677 scopus 로고    scopus 로고
    • A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC)
    • Chi KN, Hotte SJ, Ellard S, et al. A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC). ASCO Meeting Abstracts 2012;30:4514.
    • (2012) ASCO Meeting Abstracts , Issue.30 , pp. 4514
    • Chi, K.N.1    Hotte, S.J.2    Ellard, S.3
  • 39
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • 21926191 10.1158/1535-7163.MCT-11-0264 1:CAS:528:DC%2BC3MXhsFylurnF
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011;10:2298-308.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 40
    • 77950552463 scopus 로고    scopus 로고
    • Targeting the HGF/Met signalling pathway in cancer
    • 20303741 10.1016/j.ejca.2010.02.028 1:CAS:528:DC%2BC3cXkvFKqtrc%3D
    • Cecchi F, Rabe DC, Bottaro DP. Targeting the HGF/Met signalling pathway in cancer. Eur J Cancer. 2010;46:1260-70.
    • (2010) Eur J Cancer , vol.46 , pp. 1260-1270
    • Cecchi, F.1    Rabe, D.C.2    Bottaro, D.P.3
  • 41
    • 0031037754 scopus 로고    scopus 로고
    • Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
    • 9012848 10.1073/pnas.94.2.701 1:CAS:528:DyaK2sXnvVCntQ%3D%3D
    • Takayama H, LaRochelle WJ, Sharp R, et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci USA. 1997;94:701-6.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 701-706
    • Takayama, H.1    Larochelle, W.J.2    Sharp, R.3
  • 42
    • 80053571555 scopus 로고    scopus 로고
    • Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial
    • Highlights the clinical efficacy of targeting MET in prostate cancer
    • Hussain M, Smith MR, Sweeney C, et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial. ASCO Meeting Abstracts 2011;29:4516. Highlights the clinical efficacy of targeting MET in prostate cancer.
    • (2011) ASCO Meeting Abstracts , vol.29 , pp. 4516
    • Hussain, M.1    Smith, M.R.2    Sweeney, C.3
  • 43
    • 84867603148 scopus 로고    scopus 로고
    • Cabozantinib (XL184) in chemotherapy-pretreated metastatic castration resistant prostate cancer (mCRPC): Results from a phase II nonrandomized expansion cohort (NRE)
    • Smith MR, Sweeney C, Rathkopf DE, et al. Cabozantinib (XL184) in chemotherapy-pretreated metastatic castration resistant prostate cancer (mCRPC): Results from a phase II nonrandomized expansion cohort (NRE). ASCO Meeting Abstracts 2012;30:4513.
    • (2012) ASCO Meeting Abstracts , vol.30 , pp. 4513
    • Smith, M.R.1    Sweeney, C.2    Rathkopf, D.E.3
  • 44
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • 21575859 10.1016/j.ccr.2011.04.008 1:CAS:528:DC%2BC3MXmtFGls70%3D Describes the interplay between PI3K and AR
    • Carver BS, Chapinski C, Wongvipat J, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell. 2011;19:575-86. Describes the interplay between PI3K and AR.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3
  • 45
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • 21620777 10.1016/j.ccr.2011.05.006 1:CAS:528:DC%2BC3MXnsVClu7c%3D
    • Mulholland DJ, Tran LM, Li Y, et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell. 2011;19:792-804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3
  • 46
    • 77954690732 scopus 로고    scopus 로고
    • Advances in targeting SRC in the treatment of breast cancer and other solid malignancies
    • 20634194 10.1158/1078-0432.CCR-09-1834 1:CAS:528:DC%2BC3cXovVansLg%3D
    • Mayer EL, Krop IE. Advances in targeting SRC in the treatment of breast cancer and other solid malignancies. Clin Cancer Res. 2010;16:3526-32.
    • (2010) Clin Cancer Res , vol.16 , pp. 3526-3532
    • Mayer, E.L.1    Krop, I.E.2
  • 47
    • 66149164441 scopus 로고    scopus 로고
    • SRC family kinase activity is up-regulated in hormone-refractory prostate cancer
    • 19447874 10.1158/1078-0432.CCR-08-1857 1:CAS:528:DC%2BD1MXmtVKlsrc%3D
    • Tatarov O, Mitchell TJ, Seywright M, Leung HY, Brunton VG, Edwards J. SRC family kinase activity is up-regulated in hormone-refractory prostate cancer. Clin Cancer Res. 2009;15:3540-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 3540-3549
    • Tatarov, O.1    Mitchell, T.J.2    Seywright, M.3    Leung, H.Y.4    Brunton, V.G.5    Edwards, J.6
  • 48
    • 79955610443 scopus 로고    scopus 로고
    • Once-daily dasatinib: Expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer
    • 21539969 10.1016/j.urology.2011.01.006
    • Yu EY, Massard C, Gross ME, et al. Once-daily dasatinib: expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer. Urology. 2011;77:1166-71.
    • (2011) Urology , vol.77 , pp. 1166-1171
    • Yu, E.Y.1    Massard, C.2    Gross, M.E.3
  • 49
    • 83855162892 scopus 로고    scopus 로고
    • Dasatinib combined with docetaxel for castration-resistant prostate cancer: Results from a phase 1-2 study
    • 21976132 10.1002/cncr.26204 1:CAS:528:DC%2BC3MXhs1ajsbnN
    • Araujo JC, Mathew P, Armstrong AJ, et al. Dasatinib combined with docetaxel for castration-resistant prostate cancer: results from a phase 1-2 study. Cancer. 2012;118:63-71.
    • (2012) Cancer , vol.118 , pp. 63-71
    • Araujo, J.C.1    Mathew, P.2    Armstrong, A.J.3
  • 50
    • 76749144766 scopus 로고    scopus 로고
    • Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer
    • 20145158 10.1158/1078-0432.CCR-09-2917 1:CAS:528:DC%2BC3cXhvFGitb0%3D
    • Zoubeidi A, Chi K, Gleave M. Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer. Clin Cancer Res. 2010;16:1088-93.
    • (2010) Clin Cancer Res , vol.16 , pp. 1088-1093
    • Zoubeidi, A.1    Chi, K.2    Gleave, M.3
  • 51
    • 77957957234 scopus 로고    scopus 로고
    • Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
    • 20733135 10.1200/JCO.2009.26.8771 1:CAS:528:DC%2BC3cXhsVSksr7J
    • Chi KN, Hotte SJ, Yu EY, et al. Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:4247-54.
    • (2010) J Clin Oncol , vol.28 , pp. 4247-4254
    • Chi, K.N.1    Hotte, S.J.2    Yu, E.Y.3
  • 52
    • 80052468423 scopus 로고    scopus 로고
    • Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG trial P-06c
    • 21788353 10.1158/1078-0432.CCR-11-0859 1:CAS:528:DC%2BC3MXhtFSmtb%2FF
    • Saad F, Hotte S, North S, et al. Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG trial P-06c. Clin Cancer Res. 2011;17:5765-73.
    • (2011) Clin Cancer Res , vol.17 , pp. 5765-5773
    • Saad, F.1    Hotte, S.2    North, S.3
  • 53
    • 79955968629 scopus 로고    scopus 로고
    • Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
    • 21575865 10.1016/j.ccr.2011.04.010 1:CAS:528:DC%2BC3MXmtFGlsL4%3D
    • Brenner JC, Ateeq B, Li Y, et al. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell. 2011;19:664-78.
    • (2011) Cancer Cell , vol.19 , pp. 664-678
    • Brenner, J.C.1    Ateeq, B.2    Li, Y.3
  • 54
    • 79959196581 scopus 로고    scopus 로고
    • Immunotherapy for prostate cancer: Recent advances, lessons learned, and areas for further research
    • 21680544 10.1158/1078-0432.CCR-10-2656 1:CAS:528:DC%2BC3MXnsFKgsLw%3D
    • Gulley JL, Drake CG. Immunotherapy for prostate cancer: recent advances, lessons learned, and areas for further research. Clin Cancer Res. 2011;17:3884-91.
    • (2011) Clin Cancer Res , vol.17 , pp. 3884-3891
    • Gulley, J.L.1    Drake, C.G.2
  • 55
    • 30544449854 scopus 로고    scopus 로고
    • A phase i trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer
    • 16390546 10.1186/1479-5876-4-1 1:STN:280:DC%2BD28%2FmvVSksA%3D%3D
    • DiPaola RS, Plante M, Kaufman H, et al. A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer. J Transl Med. 2006;4:1.
    • (2006) J Transl Med , vol.4 , pp. 1
    • Dipaola, R.S.1    Plante, M.2    Kaufman, H.3
  • 56
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • 20100959 10.1200/JCO.2009.25.0597 1:CAS:528:DC%2BC3cXktF2ltLw%3D
    • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:1099-105.
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 58
    • 84872195017 scopus 로고    scopus 로고
    • Ipilimumab (IPI) in metastatic castrate-resistant prostate cancer (mCRPC): Results from an open-label, multicenter phase I/II study
    • Slovin SF, Hamid O, Tejwani S, et al. Ipilimumab (IPI) in metastatic castrate-resistant prostate cancer (mCRPC): Results from an open-label, multicenter phase I/II study. ASCO Meeting Abstracts 2012;30:25.
    • (2012) ASCO Meeting Abstracts , vol.30 , pp. 25
    • Slovin, S.F.1    Hamid, O.2    Tejwani, S.3
  • 59
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • 19706802 10.1158/1078-0432.CCR-09-0265 1:CAS:528:DC%2BD1MXhtVOntrjP Demonstrates the efficacy of PD-1 inhibition as an effective anti-tumor agent
    • Dewan MZ, Galloway AE, Kawashima N. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15:5379-88. Demonstrates the efficacy of PD-1 inhibition as an effective anti-tumor agent.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 60
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • 20516446 10.1200/JCO.2009.26.7609 1:CAS:528:DC%2BC3cXpslajtLw%3D
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28:3167-75.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 61
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • 22658127 10.1056/NEJMoa1200690 1:CAS:528:DC%2BC38XhtV2rs7fN
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 62
    • 84859044056 scopus 로고    scopus 로고
    • S100A9 interaction with TLR4 promotes tumor growth
    • 22470535 10.1371/journal.pone.0034207
    • Kallberg E, Vogl T, Liberg D, et al. S100A9 interaction with TLR4 promotes tumor growth. PLoS One. 2012;7:e34207.
    • (2012) PLoS One , vol.7 , pp. 34207
    • Kallberg, E.1    Vogl, T.2    Liberg, D.3
  • 63
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • 18633355 10.1038/nrc2444 1:CAS:528:DC%2BD1cXovV2lsrY%3D
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008;8:618-31.
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 64
    • 77952223624 scopus 로고    scopus 로고
    • Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors
    • 20470445 10.1186/1476-4598-9-107
    • Olsson A, Bjork A, Vallon-Christersson J, Isaacs JT, Leanderson T. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010;9:107.
    • (2010) Mol Cancer , vol.9 , pp. 107
    • Olsson, A.1    Bjork, A.2    Vallon-Christersson, J.3    Isaacs, J.T.4    Leanderson, T.5
  • 65
    • 80054761310 scopus 로고    scopus 로고
    • Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer
    • 21931019 10.1200/JCO.2011.35.6295 1:CAS:528:DC%2BC3MXhsFams7bK Illustrates importance of manipulating tumor microenvironment
    • Pili R, Haggman M, Stadler WM, et al. Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer. J Clin Oncol. 2011;29:4022-8. Illustrates importance of manipulating tumor microenvironment.
    • (2011) J Clin Oncol , vol.29 , pp. 4022-4028
    • Pili, R.1    Haggman, M.2    Stadler, W.M.3
  • 66
    • 78650177028 scopus 로고    scopus 로고
    • The epigenome as a therapeutic target in prostate cancer
    • 21060342 10.1038/nrurol.2010.185 1:CAS:528:DC%2BC3cXhsFaqsLbN
    • Perry AS, Watson RW, Lawler M, Hollywood D. The epigenome as a therapeutic target in prostate cancer. Nat Rev Urol. 2010;7:668-80.
    • (2010) Nat Rev Urol , vol.7 , pp. 668-680
    • Perry, A.S.1    Watson, R.W.2    Lawler, M.3    Hollywood, D.4
  • 67
    • 79951497419 scopus 로고    scopus 로고
    • The genomic complexity of primary human prostate cancer
    • 21307934 10.1038/nature09744 1:CAS:528:DC%2BC3MXhslWrsrs%3D
    • Berger MF, Lawrence MS, Demichelis F, et al. The genomic complexity of primary human prostate cancer. Nature. 2011;470:214-20.
    • (2011) Nature , vol.470 , pp. 214-220
    • Berger, M.F.1    Lawrence, M.S.2    Demichelis, F.3
  • 68
    • 34247506661 scopus 로고    scopus 로고
    • 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer
    • 17404097 10.1158/1078-0432.CCR-06-2381 1:CAS:528:DC%2BD2sXjs12rt7Y%3D
    • Zorn CS, Wojno KJ, McCabe MT, Kuefer R, Gschwend JE, Day ML. 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer. Clin Cancer Res. 2007;13:2136-43.
    • (2007) Clin Cancer Res , vol.13 , pp. 2136-2143
    • Zorn, C.S.1    Wojno, K.J.2    McCabe, M.T.3    Kuefer, R.4    Gschwend, J.E.5    Day, M.L.6
  • 69
    • 59149089556 scopus 로고    scopus 로고
    • Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer
    • 19176386 10.1158/0008-5472.CAN-08-2216 1:CAS:528:DC%2BD1MXhtFOkur0%3D
    • Welsbie DS, Xu J, Chen Y, et al. Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res. 2009;69:958-66.
    • (2009) Cancer Res , vol.69 , pp. 958-966
    • Welsbie, D.S.1    Xu, J.2    Chen, Y.3
  • 70
    • 72249110437 scopus 로고    scopus 로고
    • Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium
    • 19711464 10.1002/cncr.24597 1:CAS:528:DC%2BD1MXhsFOmsbzN
    • Bradley D, Rathkopf D, Dunn R, et al. Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium. Cancer. 2009;115:5541-9.
    • (2009) Cancer , vol.115 , pp. 5541-5549
    • Bradley, D.1    Rathkopf, D.2    Dunn, R.3
  • 71
    • 84866544826 scopus 로고    scopus 로고
    • A phase I/II randomized study of panobinostat and bicalutamide in castration-resistant prostate cancer (CRPC) patients progressing on second-line hormone therapy
    • Ferrari AC, Stein MN, Alumkal JJ, et al. A phase I/II randomized study of panobinostat and bicalutamide in castration-resistant prostate cancer (CRPC) patients progressing on second-line hormone therapy. ASCO Meeting Abstracts 2011;29:156.
    • (2011) ASCO Meeting Abstracts , vol.29 , pp. 156
    • Ferrari, A.C.1    Stein, M.N.2    Alumkal, J.J.3
  • 72
    • 77951884767 scopus 로고    scopus 로고
    • A phase i study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer
    • 20217089 10.1007/s00280-010-1289-x 1:CAS:528:DC%2BC3cXkslaltLc%3D
    • Rathkopf D, Wong BY, Ross RW, et al. A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2010;66:181-9.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 181-189
    • Rathkopf, D.1    Wong, B.Y.2    Ross, R.W.3
  • 73
    • 52949136114 scopus 로고    scopus 로고
    • Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade
    • Sonpavde G, Aparicio AM, Delaune R, et al. Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade. ASCO Meeting Abstracts 2008;26:5172.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 5172
    • Sonpavde, G.1    Aparicio, A.M.2    Delaune, R.3
  • 74
    • 34250641175 scopus 로고    scopus 로고
    • Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs
    • 17256134 10.1007/s00280-006-0379-2 1:CAS:528:DC%2BD2sXmsVOjsrw%3D
    • Verheul HM, Qian DZ, Carducci MA, Pili R. Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs. Cancer Chemother Pharmacol. 2007;60:329-39.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 329-339
    • Verheul, H.M.1    Qian, D.Z.2    Carducci, M.A.3    Pili, R.4
  • 75
    • 80051988763 scopus 로고    scopus 로고
    • Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers
    • 21665936 10.1158/1541-7786.MCR-10-0490 1:CAS:528:DC%2BC3MXhtVajtbvL
    • Armstrong AJ, Marengo MS, Oltean S, et al. Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol Cancer Res. 2011;9:997-1007.
    • (2011) Mol Cancer Res , vol.9 , pp. 997-1007
    • Armstrong, A.J.1    Marengo, M.S.2    Oltean, S.3
  • 76
    • 84862908058 scopus 로고    scopus 로고
    • Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen-deprivation therapy
    • 22108827 10.1158/0008-5472.CAN-11-3004 1:CAS:528:DC%2BC38Xos1KktQ%3D%3D
    • Sun Y, Wang BE, Leong KG, et al. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. 2012;72:527-36.
    • (2012) Cancer Res , vol.72 , pp. 527-536
    • Sun, Y.1    Wang, B.E.2    Leong, K.G.3
  • 77
    • 79960125220 scopus 로고    scopus 로고
    • Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors
    • 21685898 10.1038/nm.2390 1:CAS:528:DC%2BC3MXnslSmt7w%3D
    • Kottke T, Errington F, Pulido J, et al. Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. Nat Med. 2011;17:854-9.
    • (2011) Nat Med , vol.17 , pp. 854-859
    • Kottke, T.1    Errington, F.2    Pulido, J.3
  • 78
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • 18485877 10.1016/j.cell.2008.03.027 1:CAS:528:DC%2BD1cXmsVOru7w%3D
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 79
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • 19682730 10.1016/j.cell.2009.06.034 1:CAS:528:DC%2BD1MXhsVCjs73E
    • Gupta PB, Onder TT, Jiang G, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009;138:645-59.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 80
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
    • Sun Y, Campisi J, Higano C, et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012.
    • (2012) Nat Med
    • Sun, Y.1    Campisi, J.2    Higano, C.3
  • 81
    • 84859416889 scopus 로고    scopus 로고
    • Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells
    • 22350410 10.1158/0008-5472.CAN-11-3132 1:CAS:528:DC%2BC38XkvVelt70%3D
    • Mulholland DJ, Kobayashi N, Ruscetti M, et al. Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res. 2012;72:1878-89.
    • (2012) Cancer Res , vol.72 , pp. 1878-1889
    • Mulholland, D.J.1    Kobayashi, N.2    Ruscetti, M.3
  • 82
    • 84867568900 scopus 로고    scopus 로고
    • Clusterin mediates TGF-beta-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells
    • Shiota M, Zardan A, Takeuchi A, et al. Clusterin mediates TGF-beta-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells. Cancer Res 2012.
    • (2012) Cancer Res
    • Shiota, M.1    Zardan, A.2    Takeuchi, A.3
  • 83
    • 77951742472 scopus 로고    scopus 로고
    • Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors
    • 20428808 10.3892/or-00000797 1:CAS:528:DC%2BC3cXmvFyqsbk%3D
    • Wu K, Zeng J, Li L, et al. Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors. Oncol Rep. 2010;23:1545-52.
    • (2010) Oncol Rep , vol.23 , pp. 1545-1552
    • Wu, K.1    Zeng, J.2    Li, L.3
  • 84
    • 78650016651 scopus 로고    scopus 로고
    • Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
    • 21057494 10.1038/nm.2236 1:CAS:528:DC%2BC3cXhtl2jtrfK
    • Tanaka H, Kono E, Tran CP, et al. Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. Nat Med. 2010;16:1414-20.
    • (2010) Nat Med , vol.16 , pp. 1414-1420
    • Tanaka, H.1    Kono, E.2    Tran, C.P.3
  • 85
    • 59449085306 scopus 로고    scopus 로고
    • Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
    • 19047104 10.1158/1078-0432.CCR-08-1309 1:CAS:528:DC%2BD1cXhsVegtrfO
    • Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res. 2008;14:7773-80.
    • (2008) Clin Cancer Res , vol.14 , pp. 7773-7780
    • Singh, R.P.1    Raina, K.2    Sharma, G.3    Agarwal, R.4
  • 86
    • 79954611501 scopus 로고    scopus 로고
    • Phase i trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
    • 21300762 10.1158/1078-0432.CCR-10-2745 1:CAS:528:DC%2BC3MXkslCgt7Y%3D
    • LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res. 2011;17:2502-11.
    • (2011) Clin Cancer Res , vol.17 , pp. 2502-2511
    • Lorusso, P.M.1    Rudin, C.M.2    Reddy, J.C.3
  • 87
    • 84861856844 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib in advanced basal-cell carcinoma
    • 22670903 10.1056/NEJMoa1113713 1:CAS:528:DC%2BC38XovVehsb8%3D
    • Sekulic A, Migden MR, Oro AE, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012;366:2171-9.
    • (2012) N Engl J Med , vol.366 , pp. 2171-2179
    • Sekulic, A.1    Migden, M.R.2    Oro, A.E.3
  • 88
    • 84866021276 scopus 로고    scopus 로고
    • Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells
    • 22975379 10.1016/j.ccr.2012.07.016 1:CAS:528:DC%2BC38XhtlCjtb%2FO
    • Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V, et al. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Cancer Cell. 2012;22:373-88.
    • (2012) Cancer Cell , vol.22 , pp. 373-388
    • Domingo-Domenech, J.1    Vidal, S.J.2    Rodriguez-Bravo, V.3
  • 89
    • 84861690508 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401
    • 22454414 10.1200/JCO.2011.39.4767 1:CAS:528:DC%2BC38XptlyrtL0%3D
    • Kelly WK, Halabi S, Carducci M, et al. Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401. J Clin Oncol. 2012;30:1534-40.
    • (2012) J Clin Oncol , vol.30 , pp. 1534-1540
    • Kelly, W.K.1    Halabi, S.2    Carducci, M.3
  • 90
    • 81255175385 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III trial of sunitinib in combination with prednisone (SU + P) versus prednisone (P) alone in men with progressive metastatic castration-resistant prostate cancer (mCRPC)
    • Ou Y, Michaelson MD, Sengelov L, et al. Randomized, placebo-controlled, phase III trial of sunitinib in combination with prednisone (SU + P) versus prednisone (P) alone in men with progressive metastatic castration-resistant prostate cancer (mCRPC). ASCO Meeting Abstracts 2011;29:4515.
    • (2011) ASCO Meeting Abstracts , vol.29 , pp. 4515
    • Ou, Y.1    Michaelson, M.D.2    Sengelov, L.3
  • 91
    • 84859425018 scopus 로고    scopus 로고
    • Novel molecular targets for the therapy of castration-resistant prostate cancer
    • 22209376 10.1016/j.eururo.2011.12.028 1:CAS:528:DC%2BC38XltVyru78%3D
    • Agarwal N, Sonpavde G, Sternberg CN. Novel molecular targets for the therapy of castration-resistant prostate cancer. Eur Urol. 2012;61:950-60.
    • (2012) Eur Urol , vol.61 , pp. 950-960
    • Agarwal, N.1    Sonpavde, G.2    Sternberg, C.N.3
  • 92
    • 84856406031 scopus 로고    scopus 로고
    • Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer
    • 22099611 10.1016/j.eururo.2011.11.009 1:CAS:528:DC%2BC38XhsVait70%3D
    • Armstrong AJ, Eisenberger MA, Halabi S, et al. Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer. Eur Urol. 2012;61:549-59.
    • (2012) Eur Urol , vol.61 , pp. 549-559
    • Armstrong, A.J.1    Eisenberger, M.A.2    Halabi, S.3
  • 93
    • 84856812332 scopus 로고    scopus 로고
    • Changes in circulating microRNA levels associated with prostate cancer
    • 22240788 10.1038/bjc.2011.595 1:CAS:528:DC%2BC38XisVGqtbo%3D
    • Bryant RJ, Pawlowski T, Catto JW, et al. Changes in circulating microRNA levels associated with prostate cancer. Br J Cancer. 2012;106:768-74.
    • (2012) Br J Cancer , vol.106 , pp. 768-774
    • Bryant, R.J.1    Pawlowski, T.2    Catto, J.W.3
  • 94
    • 84866761624 scopus 로고    scopus 로고
    • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of Mammalian target of rapamycin
    • 22891270 10.1200/JCO.2011.40.9631 1:CAS:528:DC%2BC38Xhs1Glt73N First predictive biomarker in GU oncology
    • Armstrong AJ, George DJ, Halabi S. Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of Mammalian target of rapamycin. J Clin Oncol. 2012;30:3402-7. First predictive biomarker in GU oncology.
    • (2012) J Clin Oncol , vol.30 , pp. 3402-3407
    • Armstrong, A.J.1    George, D.J.2    Halabi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.