Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice

Biological Psychiatry

Volumn 73, Issue 5, 2013, Pages 454-463

  Hammerschmidt, Thea ^a,b   Kummer, Markus P ^a   Terwel, Dick ^a   Martinez, Ana ^d   Gorji, Ali ^b   Pape, Hans Christian ^b   Rommelfanger, Karen S ^c   Schroeder, Jason P ^c   Stoll, Monika ^e   Schultze, Joachim ^a   Weinshenker, David ^c   Heneka, Michael T ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e Leibniz Institut für Arterioskleroseforschung   (Germany)

Author keywords

Alzheimer's disease; CaMKII; degeneration; locus coeruleus; memory; noradrenaline; norepinephrine; pathogenesis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DOPAMINE BETA MONOOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NORADRENALIN; PRESENILIN 1; THREO 3,4 DIHYDROXYPHENYLSERINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME PHOSPHORYLATION; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS POTENTIAL; LEARNING; LOCUS CERULEUS; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NORADRENERGIC SYSTEM; PHENOTYPE; PRIORITY JOURNAL; SPATIAL MEMORY; UPREGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COGNITION; DOPAMINE BETA-HYDROXYLASE; EXPLORATORY BEHAVIOR; LONG-TERM POTENTIATION; MAZE LEARNING; MICE; MICE, KNOCKOUT; NEURONS; NOREPINEPHRINE; PRESENILIN-1; SYNAPSES; TYROSINE 3-MONOOXYGENASE;

EID: 84873705412     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.06.013     Document Type: Article

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