The Effects of Norepinephrine Transporter Inactivation on Locomotor Activity in Mice

Biological Psychiatry

Volumn 60, Issue 10, 2006, Pages 1046-1052

  Mitchell, Heather A ^a   Ahern, Todd H ^a   Liles, L Cameron ^a   Javors, Martin A ^b   Weinshenker, David ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

antidepressant; chronic; knockout; locomotor activity; mice; Norepinephrine transporter

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; DESIPRAMINE; DOPAMINE UPTAKE INHIBITOR; IMIPRAMINE; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; REBOXETINE; VANOXERINE; VENLAFAXINE;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENVIRONMENT; FEMALE; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOTOR ACTIVITY; MOUSE; NEUROBIOLOGY; NEUROMODULATION; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; REGULATORY MECHANISM; SEDATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CIRCADIAN RHYTHM; DOPAMINE BETA-HYDROXYLASE; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; ENZYME ACTIVATION; EXPLORATORY BEHAVIOR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33750484686     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.03.057     Document Type: Article

References (37)

1. Ahern T.H., Javors M.A., Eagles D.A., Martillottii J., Mitchell H.A., Liles L.C., and Weinshenker D. The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. Neuropsychopharmacology 31 (2006) 730-738
2. Benmansour S., Cecchi M., Morilak D.A., Gerhardt G.A., Javors M.A., Gould G.G., and Frazer A. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J Neurosci 19 (1999) 10494-10501
3. Bergstrom D.A., and Kellar K.J. Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment. J Pharmacol Exp Ther 209 (1979) 256-261
4. Brocco M., Dekeyne A., Veiga S., Girardon S., and Millan M.J. Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents. Pharmacol Biochem Behav 71 (2002) 667-680
5. Brown A.S., and Gershon S. Dopamine and depression. J Neural Transm Gen Sect 91 (1993) 75-109
6. Brunello N., Mendlewicz J., Kasper S., Leonard B., Montgomery S., Nelson J., et al. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol 12 (2002) 461-475
7. Caligiuri M.P., and Ellwanger J. Motor and cognitive aspects of motor retardation in depression. J Affect Disord 57 (2000) 83-93
8. Fishman R.H., Feigenbaum J.J., Yanai J., and Klawans H.L. The relative importance of dopamine and norepinephrine in mediating locomotor activity. Prog Neurobiol 20 (1983) 55-88
9. Frazer A. Pharmacology of antidepressants. J Clin Psychopharmacol 17 suppl 1 (1997) 2S-18S
10. Frazer A. Norepinephrine involvement in antidepressant action. J Clin Psychiatry 61 suppl 10 (2000) 25-30
11. Geyer M.A. Serotonergic functions in arousal and motor activity. Behav Brain Res 73 (1996) 31-35
12. Grant M.M., and Weiss J.M. Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity. Biol Psychiatry 49 (2001) 117-129
13. Harkin A., Kelly J.P., McNamara M., Connor T.J., Dredge K., Redmond A., and Leonard B.E. Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression. Eur J Pharmacol 364 (1999) 123-132
14. Harro J., Oreland L., Vasar E., and Bradwejn J. Impaired exploratory behaviour after DSP-4 treatment in rats: Implications for the increased anxiety after noradrenergic denervation. Eur Neuropsychopharmacol 5 (1995) 447-455
15. He M., and Shippenberg T.S. Strain differences in basal and cocaine-evoked dopamine dynamics in mouse striatum. J Pharmacol Exp Ther 293 (2000) 121-127
16. Invernizzi R.W., and Garattini S. Role of presynaptic alpha2-adrenoceptors in antidepressant action: Recent findings from microdialysis studies. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 819-827
17. Kuzmin A., and Johansson B. Reinforcing and neurochemical effects of cocaine: differences among C57, DBA, and 129 mice. Pharmacol Biochem Behav 65 (2000) 399-406
18. Marks H.E., Remley N.R., Seago J.D., and Hastings D.W. Effects of bilateral lesions of the olfactory bulbs of rats on measures of learning and motivation. Physiol Behav 7 (1971) 1-6
19. Nestler E.J., McMahon A., Sabban E.L., Tallman J.F., and Duman R.S. Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. Proc Natl Acad Sci U S A 87 (1990) 7522-7526
20. Ressler K.J., and Nemeroff C.B. Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry 46 (1999) 1219-1233
21. Rommelspacher H., Wolffgramm J., and Widjaja S. Effects of desipramine on rat behavior are prevented by concomitant treatment with ethanol. Pharmacol Biochem Behav 32 (1989) 533-542
22. Sachdev P., and Aniss A.M. Slowness of movement in melancholic depression. Biol Psychiatry 35 (1994) 253-262
23. Sobin C., and Sackeim H.A. Psychomotor symptoms of depression. Am J Psychiatry 154 (1997) 4-17
24. Stone E.A., Lin Y., Rosengarten H., Kramer H.K., and Quartermain D. Emerging evidence for a central epinephrine-innervated alpha 1-adrenergic system that regulates behavioral activation and is impaired in depression. Neuropsychopharmacology 28 (2003) 1387-1399
25. Stone E.A., Zhang Y., Rosengarten H., Yeretsian J., and Quartermain D. Brain alpha 1-adrenergic neurotransmission is necessary for behavioral activation to environmental change in mice. Neuroscience 94 (1999) 1245-1252
26. Szot P., Weinshenker D., White S.S., Robbins C.A., Rust N.C., Schwartzkroin P.A., and Palmiter R.D. Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuli. J Neurosci 19 (1999) 10985-10992
27. Thomas S.A., Marck B.T., Palmiter R.D., and Matsumoto A.M. Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. J Neurochem 70 (1998) 2468-2476
28. Thomas S.A., Matsumoto A.M., and Palmiter R.D. Noradrenaline is essential for mouse fetal development. Nature 374 (1995) 643-646
29. Thomas S.A., and Palmiter R.D. Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Cell 91 (1997) 583-592
30. Thomas S.A., and Palmiter R.D. Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory. Behav Neurosci 111 (1997) 579-589
31. Tucker J.C., and File S.E. The effects of tricyclic and 'atypical' antidepressants on spontaneous locomotor activity in rodents. Neurosci Biobehav Rev 10 (1986) 115-121
32. Vogel G.W., Minter K., and Woolwine B. Effects of chronically administered antidepressant drugs on animal behavior. Physiol Behav 36 (1986) 659-666
33. Weinshenker D., Miller N.S., Blizinsky K., Laughlin M.L., and Palmiter R.D. Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals. Proc Natl Acad Sci U S A 99 (2002) 13873-13877
34. Weinshenker D., White S.S., Javors M.A., Palmiter R.D., and Szot P. Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Brain Res 946 (2002) 239-246
35. Womer D.E., Jones B.C., and Erwin V.G. Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909, epidepride, and SCH 23390 in C57BL and DBA mice. Pharmacol Biochem Behav 48 (1994) 327-335
36. Wong E.H., Sonders M.S., Amara S.G., Tinholt P.M., Piercey M.F., Hoffmann W.P., Hyslop D.K., Franklin S., Porsolt R.D., Bonsignori A., Carfagna N., and McArthur R.A. Reboxetine: A pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry 47 (2000) 818-829
37. Xu F., Gainetdinov R.R., Wetsel W.C., Jones S.R., Bohn L.M., Miller G.W., Wang Y.M., and Caron M.G. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 3 (2000) 465-471