Inhibition of formyl peptide-stimulated superoxide anion generation by Fal-002-2 occurs mainly through the blockade of the p21-activated kinase and protein kinase C signaling pathways in ratneutrophils

European Journal of Pharmacology

Volumn 701, Issue 1-3, 2013, Pages 114-123

  Tsai, Ya Ru ^a   Huang, Li Jiau ^b   Lin, Hui Yi ^b   Hung, Yun Jie ^a   Lee, Miau Rong ^b   Kuo, Sheng Chu ^b   Hsu, Mei Feng ^b   Wang, Jih Pyang ^a  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Neutrophils; p21 Activated kinase; p47 phox; Protein kinase C; Superoxide anion

Indexed keywords

6 CHLORO 2 (2 CHLOROPHENYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ANTIINFLAMMATORY AGENT; CALCIUM ION; FAL 002 2; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C BETA2; PROTEIN KINASE C DELTA; PROTEIN KINASE C ZETA; PROTEIN P22; PROTEIN P47; RAC1 PROTEIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOSYNTHESIS; CALCIUM CELL LEVEL; CELL MEMBRANE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; IC 50; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALGRANULIN B; CELL MEMBRANE; CYCLIC AMP; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADPH OXIDASE; NEUTROPHILS; P21-ACTIVATED KINASES; PROTEIN KINASE C; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; QUINOLONES; RATS; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 84873700030     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.015     Document Type: Article

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