Inulin: therapeutic potential, prebiotic properties and immunological aspects

Food and Agricultural Immunology

Volumn 24, Issue 1, 2013, Pages 21-31

  de Almeida Gualtieri, Karina ^a,b   Losi Guembarovski, Roberta ^a   Oda, Julie Massayo Maeda ^a   Fiori Lopes, Leandra ^a   Ketelut Carneiro, Natalia ^a   de Castro, Vania Darc ^a   Soni Neto, Jamil ^a   Watanabe, Maria Angelica Ehara ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b Filadelfia University   (Brazil)

Author keywords

colon disease; immunity; inulin; prebiotics

Indexed keywords

EID: 84873675814     PISSN: 09540105     EISSN: 14653443     Source Type: Journal    
DOI: 10.1080/09540105.2011.640993     Document Type: Review

References (54)

1. Abrams, S.A. 2005. Calcium supplementation during childhood: Long-term effects on bone mineralization. Nutrition Reviews, 63(7): 251-255.
2. Abrams, S.A., Griffin, I.J., Hawthorne, K.M., Liang, L., Gunn, S.K.Darlington, G. 2005. A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. The American Journal of Clinical Nutrition, 82(2): 471-476.
3. Alrawi, S.J., Schiff, M., Carroll, R.E., Dayton, M., Gibbs, J.F.Kulavlat, M. 2006. Aberrant crypt foci. Anticancer Research, 26: 107-119.
4. Benyacoub, J., Rochat, F., Saudan, K.Y., Rochat, I., Antilles, N.Cherbut, C. 2008. Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice. The Journal of Nutrition, 138(1): 123-129.
5. Bodera, P. 2008. Influence of prebiotics on the human immune system (GALT). Recent Patents on Inflammation & Allergy Drug Discovery, 2 2, 149-153. doi:10.2174/187221308784543656.
6. Brasil. 2011. Lei Orgânica da Saúde n° 8080, de 19 de setembro de 1990. Dispõe sobre as condições para a promoção, proteção e recuperação da saúde, a organização e o funcionamento dos serviços correspondentes e dá outras providências. Diário Oficial [da] República Federativa do Brasil, DF, 20 set. 1990. Disponível em: Retrieved July 15, 2011, from http://www.senado.gov.br (In Portuguese only).
7. de Vrese, M. & Schrezenmeir, J. 2008. Probiotics, prebiotics, and synbiotics. Advances in Biochemical Engineering/Biotechnology, 111, 1-66. doi:10.1007/10_2008_097.
8. Euler, A.R, Mitchell, D.K, Kline, R. and Pickering, L.K. 2005. Prebiotic effect of fructo-oligosaccharide supplemented term infant formula at two concentrations compared with unsupplemented formula and human milk. Journal of Pediatric Gastroenterology & Nutrition, 40(2): 157-164.
9. Fanaro, S., Chierici, R., Guerrini, P. and Vigi, V. 2003. Intestinal microflora in early infancy: Composition and development. Acta Pediatrica SUPPL.ement, 91(441): 48-55.
10. Fuchs, R.H.B., Borsato, D., Bona, E. and Hauly, M.C.O. 2005. "Iogurte" de soja suplementado com oligofrutose e inulina. Ciência e Tecnologia de Alimentos, Campinas, 25(1): 175-181.
11. Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J.H., Walsh, S.V., et al. 2005. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: A randomised controlled pilot trial, Gut, 54, 242-249. doi:10.1136/gut.2004.044834.
12. Gibson, G.R., Beatty, E.B., Wang, X., & Cummings, J.H. 1995. Selective stimulation of Bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology, 108 4, 975-982. doi:10.1016/0016-5085(95)90192-2.
13. Gourineni, V.P., Verghese, M., Boateng, J., Shackelford, L., & Bhat, K.N. 2011. Chemopreventive potential of synergy 1 and soybean in reducing azoxymethane-induced aberrant crypt foci in fisher 344 male rats. Journal of Nutrition and Metabolism, Article ID 983038, 8. doi:10.1155/2011/983038.
14. Gregory, K. 2008. Inulin-Type Prebiotics-A Review: Part 1. Alternative Medicine Review, 13(4): 315-329.
15. Griffin, I.J., Davila, P.M., & Abrams, S.A. 2002. Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. The British Journal of Nutrition, 87 2, S 187-S191. doi:10.1079/BJN/2002536.
16. Griffin, I.J., Hicks, P.M.D., Heaney, R.P., & Abrams, S.A. 2003. Enriched chicory inulin increases calcium absorption in girls with lower calcium absorption. Nutrition Research, 23, 901-909. doi:10.1016/S0271-5317(03)00085-X.
17. Haschke, F., Firmansyah, A., Meng, M., Steenhout, P., & Carrié, A L. 2001. Functional food for infants and children. Monatsschrift Kinderheilkunde, 149 13, S 66-S70. doi:10.1007/s001120170011.
18. Hijova, E., Chmelarova, A., Bomba, A. and Zitnan, R. 2009. Prebiotic foodstuffs and their health benefits in experiment. Bratislavské Lekárske Listy, 10(9): 523-525.
19. Kapiki, A., Costalos, C., Oikonomidou, C., Triantafyllidou, A., Loukatou, E. and Pertrohilou, V. 2007. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Human Development, 83(5): 335-339.
20. Kelly, G. 2008. Inulin-type prebiotics: A review (Part 1). Alternative Medicine Review, 13(4): 315-329.
21. Kelly, G. 2009. Inulin-type prebiotics: A review. (Part 2). Alternative Medicine Review, 4(1): 36-55.
22. Kim, Y.S. and Milner, J.A. 2007. Dietary modulation of colon cancer risk. The Journal of Nutrition, 137(11): 2576S-2579S.
23. Leenen, C.H. and Dieleman, L.A. 2007. Inulin and oligofructose in chronic inflammatory bowel disease. The Journal of Nutrition, 137(11): 2572S-2575S.
24. Limburg, P.J., Mahoney, M.R., Ziegler, K.L., Sontag, S.J., Schoen, R.E.Benya, R. 2011. Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. Cancer Prevention Research (Phila), 4(2): 259-269.
25. Liu, J., Waterhouse, A.L., & Chatterton, N.J. 1993. Proton and carbon NMR chemical-shift assignments for [beta-D-Fru f-(2-- > 1)]3-(2 < = = > 1)-alpha-D-Glc p (nystose) and [beta-D-Fru f-(2-- > 1)]4-(2 < = = > 1)-alpha-D-Glc p (1,1,1-kestopentaose) from two-dimensional NMR spectral measurements. Carbohydrate Research, 245 1, 11-19. doi:10.1016/0008-6215(93)80056-K.
26. Lomax, A.R., & Calder, P.C. 2009. Prebiotics, immune function, infection and inflammation: A review of the evidence. British Journal of Nutrition, 101, 633-658. doi:10.1017/S0007114508055608.
27. Lugonja, N.M., Martinov, O.B., Rasovic, M.R., Spasic, S.D., Gojgic, G.D.J., & Vrvic, M.M. 2010. A comparative investigation of an in vitro and clinical test of the bificogenic effect of an infant formula. Journal of Clinical Biochemistry and Nutrition, 47 3, 208-216. doi:10.3164/jcbn.10-54.
28. Macfarlane, G.T., Steed, H., & Macfarlane, S. 2008. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. Journal of Applied Microbiology, 104 2, 305-344. doi:10.1016/S0271-5317(03)00085-X.
29. Madrigal, L. and Sangronis, E. 2007. Inulin and derivates as key ingredients in functional foods. Archivos Latinoamericanos de Nutrición, 57(4): 387-396.
30. Markowitz, S.D., & Bertagnolli, M.M. 2009. Molecular origins of cancer: Molecular basis of colorectal cancer. The New England Journal of Medicine, 361 25, 2449-2460. doi:10.1056/NEJMra0804588.
31. Marteau, P., Jacobs, H., Cazaubiel, M., Signoret, C., Prevel, J.M., & Housez, B. 2011. Effects of chicory inulin in constipated elderly people: A double-blind controlled trial. International Journal of Food Sciences and Nutrition, 62 2, 164-170. doi:10.3109/09637486.2010.527323.
32. Martin, F.P., Wang, Y., Sprenger, N., Yap, I.K., Rezzi, S.Ramadan, Z. 2008. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Molecular Systems Biology, 4: 205
33. Meyer, D., & Stasse-Wolthuis, M. 2009. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. European Journal of Clinical Nutrition, 63 11, 1277-1289. doi:10.1038/ejcn.2009.64.
34. Misikangas, M., Tanayama, H., Rajakangas, J., Lindén, J., Pajari, A.M., & Mutanen, M. 2008. Inulin results in increased levels of beta-catenin and cyclin D1 as the adenomas increase in size from small to large in the Min/ + mouse. The British Journal of Nutrition, 99 5, 963-970. doi:10.1017/S0007114507853414.
35. Moshfegh, A.J., Friday, J.E., Goldman, J.P. and Ahuja, J.K. 1999. Presence of inulin and oligofructose in the diets of Americans. The Journal of Nutrition, 129(7): 1407S-1411S.
36. Munjal, U., Glei, M., Pool-Zobel, B.L., & Scharlau, D. 2009. Fermentation products of inulin-type fructans reduce proliferation and induce apoptosis in human colon tumour cells of different stages of carcinogenesis. The British Journal of Nutrition, 102 5, 663-671. doi:10.1017/S0007114509274770.
37. Parnell, J.A. and Reimer, R.A. 2010. Effect of prebiotic fibre supplementation on hepatic gene expression and serum lipids: A dose-response study in JCR:LA-cp rats. British Journal of Nutrition, 103: 1577-1584.
38. Pool-Zobel, B.L. 2005. Inulin-type fructans and reduction in colon cancer risk: Review of experimental and human data. British Journal of Nutrition, 93(SUPPL. 1): S73-S90.
39. Pool-Zobel, B.L. and Sauer, J. 2007. Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans. The Journal of Nutrition, 137(11): 2580S-2584S.
40. Rafter, J., Bennett, M., Caderni, G., Clune, Y., Hughes, R.Karlsson, P.C. 2007. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. American Journal of Clinical Nutrition, 85(2): 488-496.
41. Ramirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A., Holtrop, G., & Louis, P. 2009. Effect of inulin on the human gut microbiota: Stimulation of Bifidobacterium adolescents and Faecalibacterium prausnitzii. The British Journal of Nutrition, 101 4, 541-550. doi:10.1017/S0007114508019880.
42. Roberfroid, M.B. 1999. Concept in functional foods: The case of inulin and oligofructose. Journal of Nutrition, 129(SUPPL.): 1398-1401.
43. Roberfroid, M.B. 2007. Inulin-type fructans: Functional food ingredients. The Journal of Nutrition, 137(11): 2493S-2502S.
44. Ryz, N.R., Meddings, J.B., & Taylor, C.G. 2009. Long-chain inulin increases dendritic cells in the Peyer's patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status. The British Journal of Nutrition, 101 11, 1653-1663. doi:10.1017/S000711450812342X.
45. Sherman, P.M., Cabana, M., Gibson, G.R., Koletzko, B.V., Neu, J., et al. 2010. Potential roles and clinical utility of prebiotics in newborns, infants, and children: Proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008. Journal of Pediatric, 155 5, S 61-S70. doi:10.1016/j.jpeds.2009.08.022.
46. Silva, D.O., Engstrom, E.M., Zaborowski, E.L. 2002. Sisvan: Instrumento para o combate aos distúrbios nutricionais na atenção à saúde: o diagnóstico coletivo. Rio de Janeiro: Fiocruz, 187 p. (In Portuguese only).
47. Stoyanova, S., Geuns, J., Hideg, E., & Van Den Ende, W. 2010. The food additives inulin and stevioside counteract oxidative stress. International Journal of Food Sciences and Nutrition, 62 3, 207-214. doi:10.3109/09637486.2010.523416.
48. Trushina, E.N., Martynova, E.A., Nikitiuk, D.B., Mustafina, O.K. and Bai{dotless}̌garin, E.K. 2005. The influence of dietary inulin and oligofructose on the cell-mediated and humoral immunity in rats. Voprosy pitaniya, 74(3): 22-27.
49. Van den Heuvel, E.G., Muys, T., van Dokkum, W. and Schaafsma, G. 1999. Oligofructose stimulates calcium absorption in adolescents. The American Journal of Clinical Nutrition, 69(3): 544-548.
50. Van Loo, J., Coussement, P., de Leenheer, L., Hoebregs, H., & Smits, G. 1995. On the presence of inulin and oligofructose as natural ingredients in the western diet. Critical Reviews in Food Science and Nutrition, 35 6, 525-552. doi:10.1080/10408399509527714.
51. Vos, A.P., Haarman, M., Buco, A., Govers, M., Knol, J., et al. 2006. A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model. International Immunopharmacology, 6 8, 1277-1286. doi:10.1016/j.intimp.2006.03.010.
52. Waligora-Dupriet, A.J., Campeotto, F., Nicolis, I., Bonet, A., Soulaines, P.Dupont, C. 2007. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. International Journal of Food Microbiology, 113(1): 108-113.
53. Wattenberg, L. 1992. Inhibition of carcinogenicity by minor dietary constituents. Cancer Research, 52(7): 2085s-2091s.
54. Watzl, B., Girrbach, S., & Roller, M. 2005. Inulin, oligofructose and immunomodulation. The British Journal of Nutrition, 93 1, S49-S55. doi:10.1079/BJN20041357.