Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 33, Issue 1, 2013, Pages 43-50

  You, Hao ^a,b   Kong, Meng Meng ^a   Wang, Li Ping ^a   Xiao, Xiao ^a   Liao, Han Lin ^a   Bi, Zhuo Yue ^a   Yan, Hong ^a   Wang, Hong ^a   Wang, Chun Hong ^a   Ma, Qiang ^c   Liu, Yan Qun ^b   Bi, Yong Yi ^a  

^a WUHAN UNIVERSITY   (China)

^b JIANGHAN UNIVERSITY   (China)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

2 (morpholin 4 yl) benzo h chomen 4 one; Akt; benzene; DNA double strand break; DNA dependent protein kinase catalytic subunit

Indexed keywords

2 (MORPHOLIN 4 YL)BENZO(H)CHROMEN 4 ONE; 2-(MORPHOLIN-4-YL)BENZO(H)CHROMEN-4-ONE; BENZENE; CHROMONE DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; MORPHOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CATALYSIS; DNA DAMAGE; DNA REPAIR; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; K562 CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN SUBUNIT;

APOPTOSIS; BENZENE; CATALYSIS; CHROMONES; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; HUMANS; K562 CELLS; MORPHOLINES; PROTEIN SUBUNITS;

EID: 84873642120     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-013-1069-z     Document Type: Article

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