Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils

Drug Metabolism and Disposition

Volumn 37, Issue 2, 2009, Pages 282-291

  Zhao, Zhiwei ^a,b   He, Xiaoqing ^b   Bi, Yongyi ^a   Xia, Ying ^a   Tao, Ning ^a   Li, Li ^a   Qiang, Ma ^b  

^a WUHAN UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE 1 MONOOXYGENASE; BENZENE; BIOLOGICAL MARKER; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2B6; CYTOCHROME P450 4F3A; HYDROQUINONE; LEUKOTRIENE B4; MESSENGER RNA; PHENOL; RETINOIC ACID; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ADULT; APLASTIC ANEMIA; APOPTOSIS; ARTICLE; BLOOD TOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKOCYTE; METABOLITE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PRIORITY JOURNAL;

APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BENZENE; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; MICROARRAY ANALYSIS; NEUTROPHILS; OCCUPATIONAL DISEASES; RNA;

EID: 59649129904     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.023192     Document Type: Article

References (27)

1. Aksoy M (1989) Hematotoxicity and carcinogenicity of benzene. Environ Health Perspect 82:193-197.
2. Agency for Toxic Substances and Disease Registry (1997) Toxicological Profile for Benzene. U.S. Public Health Service, Atlanta.
3. Belhacène N, Maulon L, Guérin S, Ricci JE, Mari B, Colin Y, Cartron JP, and Auberger P (1998) Differential expression of the Kell blood group and CD10 antigens: two related membrane metallopeptidases during differentiation of K562 cells by phorbol ester and hemin. FASEB J 12:531-539.
4. Chen L, Bi YY, Tao N, Wang H, Xia Y, and Ma Q (2005) cDNA microarray to identify the significance of DNA replication and damage repair genes associated with benzene poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:248-251.
5. Chepiga TA, Yang CS, and Snyder R (1991) Benzene metabolism by two purified, reconstituted rat hepatic mixed function oxidase systems. Adv Exp Med Biol 283:261-265.
6. 4 ω-hydroxylase. J Biol Chem 274:21191-21199.
7. Collins SJ, Ruscetti FW, Gallagher RE, and Gallo RC (1979) Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J Exp Med 149:969-974.
8. Forrest MS, Lan Q, Hubbard AE, Zhang L, Vermeulen R, Zhao X, Li G, Wu YY, Shen M, Yin S, et al. (2005) Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers. Environ Health Perspect 113:801-807.
9. Hu X, Roberts JR, Apopa PL, Kan YW, and Ma Q (2006) Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol Cell Biol 26:940-954.
10. Kikuta Y, Kusunose E, Endo K, Yamamoto S, Sogawa K, Fujii-Kuriyama Y, and Kusunose M (1993) A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 ω-hydroxylase. J Biol Chem 268:9376-9380.
11. Kikuta Y, Yamashita Y, Kashiwagi S, Tani K, Okada K, and Nakata K (2004) Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells. Biochim Biophys Acta 1683:7-15.
12. Kim S, Lan Q, Waidyanatha S, Chanock S, Johnson BA, Vermeulen R, Smith MT, Zhang L, Li G, Shen M, et al. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet Genomics 17:789-801.
13. Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, Rappaport SM, Shen M, Alter BP, Wu Y, et al. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science 306:1774-1776.
14. 1]benzene. Biochem J 54:231-238.
15. Ross D, Siegel D, Schattenberg DG, Sun XM, and Moran JL (1996) Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect 104 (Suppl 6):1177-1182.
16. Samuelsson B (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220:568 -575.
17. Shak S and Goldstein IM (1984) ω-Oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. J Biol Chem 259:10181-10187.
18. Snyder R (2002) Benzene and leukemia. Crit Rev Toxicol 32:155-210.
19. 5, microsomal epoxide hydrolase, and glutathione transferases: evidence for an important role of microsomal epoxide hydrolase in the formation of hydroquinone. Toxicol Appl Pharmacol 122:172-181.
20. Snyder R and Hedli CC (1996) An overview of benzene metabolism. Environ Health Perspect 104 (Suppl 6):1165-1171.
21. Snyder R, Witz G, and Goldstein BD (1993b) The toxicology of benzene. Environ Health Perspect 100:293-306.
22. Telford WG, Komoriya A, and Packard BZ (2004) Multiparametric analysis of apoptosis by flow and image cytometry. Methods Mol Biol 263:141-160.
23. Valentine JL, Lee SS, Seaton MJ, Asgharian B, Farris G, Corton JC, Gonzalez FJ, and Medinsky MA (1996) Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol Appl Pharmacol 141:205-213.
24. Wallace L (1996) Environmental exposure to benzene: an update. Environ Health Perspect 104 (Suppl 6):1129-1136.
25. Wang T (2004) Physiology. High Education Press, Beijing.
26. Xia Y, Zhang HX, Bi YY, Chen XH, Zhao ZW, and Wang H (2005) Analysis on tumor related gene expression profiles in benzene poisoning using cDNA microarray. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:256-259.
27. Zhao ZW, Bi YY, Zhang HX, Mao ZF, Chen XH, andMaQ(2005) Detection of apoptosis genes differentially expressed in patients with different degrees of benzene poisoning by cDNA microarray. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:245-247.