Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway

International Journal of Oncology

Volumn 42, Issue 3, 2013, Pages 1018-1026

  Wang, Chong Zhi ^a   Calway, Tyler D ^a   Wen, Xiao Dong ^a   Smith, Jacob ^a   Yu, Chunhao ^a   Wang, Yunwei ^b   Mehendale, Sangeeta R ^a   Yuan, Chun Su ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Baicalein; Baicalin; Colorectal cancer; Hydrophobic flavonoids; Mitochondrial apoptotic pathway; Scutellaria baicalensis; Wogonin

Indexed keywords

AGLYCONE RICH FRACTION; BAICALEIN; BAICALIN; CYCLIN A; CYCLIN B1; FLAVONOID; SCUTELLARIA BAICALENSIS EXTRACT; UNCLASSIFIED DRUG; WOGONIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL ASSAY; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PLANT ROOT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOPREVENTION; COLORECTAL NEOPLASMS; CYCLIN A; CYCLIN B1; ENZYME INHIBITORS; FLAVANONES; FLAVONOIDS; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; IRIDOIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHYTOTHERAPY; PLANT EXTRACTS; S PHASE CELL CYCLE CHECKPOINTS; SCUTELLARIA BAICALENSIS;

EID: 84873640592     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1777     Document Type: Article

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