Boron neutron capture therapy and 18F-labelled borophenylalanine positron emission tomography: A critical and clinical overview of theliterature

Applied Radiation and Isotopes

Volumn 74, Issue , 2013, Pages 91-101

  Evangelista, Laura ^a   Jori, Giulio ^b   Martini, Domenico ^c   Sotti, Guido ^a  

^a VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c Oncology Hospital of Macerata   (Italy)

Author keywords

18F BPA; BNCT; BPA fructose; Molecular imaging; PET

Indexed keywords

18F-BPA; BNCT; BORON ATOM; BORON NEUTRON CAPTURE THERAPY; BORON-10; BORON-CONTAINING; BPA-FRUCTOSE; CANCER CELLS; CLINICAL TRIAL; IN-VIVO; MALIGNANT LESION; NEOPLASTIC TISSUE; NORMAL TISSUE; PET IMAGING; POSITRON EMISSION TOMOGRAPHY (PET); THERAPEUTIC DOSE; THERMAL NEUTRONS; TUMOR CELLS; TUMOUR CELLS;

ISOTOPES; MOLECULAR IMAGING; NEUTRONS; POLYETHYLENE TEREPHTHALATES; POSITRON EMISSION TOMOGRAPHY; TUMORS;

BORON;

4 BORONOPHENYLALANINE F 18; BORON 10; CISPLATIN; FLUOROURACIL; LITHIUM; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ALPHA RADIATION; BRAIN CANCER; CANCER CELL; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CLINICAL TRIAL (TOPIC); COMPARTMENT MODEL; CYTOTOXICITY; DIAGNOSTIC VALUE; DRUG ACCUMULATION; DRUG METABOLISM; DRUG STRUCTURE; GLIOBLASTOMA; HEAD AND NECK CANCER; HUMAN; IN VIVO STUDY; LYMPH NODE METASTASIS; MALIGNANT MENINGIOMA; MELANOMA; MOUTH CANCER; NEURILEMOMA; NEUTRON CAPTURE THERAPY; NEUTRON RADIATION; NONHUMAN; NOSE CANCER; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION ABSORPTION; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; REVIEW; SALIVARY GLAND CANCER; SKIN CANCER; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; TREATMENT PLANNING;

EID: 84873608132     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2013.01.001     Document Type: Review

References (60)

1. 18F-BPA PET. Case Rep. 2006, 28:850-855.
2. Altieri S. Neutron autoradiography imaging of selective boron uptake in human metastatic tumors. Appl. Radiat. Isot. 2008, 66(12):1850-1855.
3. Altieri S., Bortolussi S., Bruschi P., Fossati F., Vittor K., Nano R., Facoetti A., Chiari P., Bakeine J., Clerici A., Ferrari C., Salvucci O. Boron absorption imaging in rat lung colon adenocarcinoma metastases. J. Phys. Conf. Ser. 2006, 41:484-495.
4. Ariyoshi Y.M.S., Kimura Y., Shimahara T., Kawabata S., Nagata K., Suzuki M., Maruhashi A., Ono K., Shimahara M. Boron neuron capture therapy using epithermal neutrons for recurrent cancer in the oral cavity and cervical lymph node metastasis. Oncol. Rep. 2007, 18:861-866.
5. Barth R.F., Coderre J., Vincente M.G.H., Blue T.E. Boron neutron capture therapy of cancer: current status and future prospects. Clin. Cancer Res. 2005, 11(11):3987-4002.
6. 18F]fluoroethyl)-l-tyrosine (F-18 FET) PET for glioma grading: assessment of individual probability of malignancy. Clin. Nucl. Med. 2011, 36(10):841-847.
7. Capuani S., Gili T., Bozzali M., Russo S., Porcari P., Cametti C., D'Amore E., Colasanti M., Venturini G., Maraviglia B., Lazzarino G., Pastore F.S. L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: a new strategy to improve a BNCT efficacy. Int. J. Radiat. Oncol. Biol. Phys. 2008, 72(2):562-567.
8. Coderre J.A., Glass J., Fairchild R.G., Roy U., Cohen S., Fand I. Selective targeting of borophenylalanine to melanoma in BALB/c mice for neutron capture therapy. Cancer Res. 1987, 47(23):6377-6383.
9. Dougherty T.J., Gomer C.J., Henderson B.W., Jori G., Kessel D., Korbelik M., Moan J., Peng Q. Photodynamic therapy. J. Natl. Cancer Inst. 1998, 90:889-905.
10. Esposito J., Ceballos C., Soncin M., Fabris C., Friso E., Moro D., Colautti P., Jori G., Rosi G., Nava E. Feasibility of BNCT radiobiological experiments at the HYTHOR facility. Nucl. Instrum. Methods Phys. Res., Sect. B 2008, 266(2587-2593):2587.
11. Fabris C., Jori G., Giuntini F., Roncucci G. Photosensitising properties of a boronated phtalocianine: studies at the molecular and cellular level. J. Photochem. Photobiol., B 2001, 64:1-7.
12. Fabris C., Vicente M.G.H., Ehrong Hao, Friso E., Borsetto L., Jori G., Miotto G., Colautti P., Moro D., Esposito J., Ferretti A., Rossi C.R., Nitti D., Sotti G., M.Soncin Tumour-localizing and -photosensitising properties of meso-tetra (4-nido-carboranylphenyl)porphyrin (H2TCP). J. Photochem. Photobiol., B 2007, 89:131-138.
13. 10B boron neutron capture therapy: enhancement of the tumour dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content; a theoretical evaluation. Int. J. Radiat. Oncol. Biol. Phys. 1985, 11:831-840.
14. 10B-enriched carboranyl-containing phtalocianine as a radio- and photo-sensitising agent for boron neutron capture therapy and photodynamic therapy of tumours: in vitro and in vivo studies. Photochem. Photobiol. Sci. 2006, 5:39-50.
15. 18F]fluoroethyl)-l-tyrosine (FET)- and l-[methyl-11C]methionine (MET)-PET in patients with brain gliomas and metastases. Int. J. Radiat. Oncol. Biol. Phys. 2011, 81(4):1049-1058.
16. Haginomori S., Miyatake S., Inui T., Araki M., Kawabata S., Takamaki A., Lee K., Takenaka H., Kuroiwa T., Uesugi Y., Kumada H., Ono K. Planned fractionated boron neutron capture therapy using epithermal neutrons for a patient with recurrent squamous cell carcinoma in the temporal bone: a case report. Head Neck 2009, 31:412-418.
17. Hao E., Friso E., Miotto G., Jori G., Soncin M., Fabris C., Sibrian-Vazquez M. Vicente MGH. Synthesis and biological investigations of tetrakis (p-carboranylthio-tetrafluorophenyl)chlorin (TPFC). Org. Biomol. Chem. 2008, 6:3732-3740.
18. 10B atoms in a single molecule for the application to MRI and BNCT. Bioorg. Med. Chem. 2006, 14:3258-3262.
19. Hattory Y., Yamamoto H., Ando H., Kondoh H., Asano T., Kirihata M., Yamaguchi Y., Wakamiya T. Synthesis and evaluation as MRI probe of the trifluoromethylated p-borophenylalanine and its alcohol derivative. Bioorg. Med. Chem. 2007, 15:2198-2205.
20. 18F]fluoro-l-phenylalanine in sporadic and neurofibromatosis 2-related shwannoma and maningioma studied with PET. Eur. J. Nucl. Med. Mol. Imaging 2007, 34(1):87-94.
21. Honigsmann H., Jori G., Young A.R. The Fundamental Bases of Phototherapy and Radiotherapy OEMF, Milan, Italy. 1999.
22. 18F-fluoro-l-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain barrier disruption. J. Nucl. Med. 2005, 46:1858-1865.
23. Huang S.C., Phelps M.E., Hoffman E.J., Sideris K., Selin C.J., Kuhl D.E. Non-invasive determination of local cerebral metabolic rate of glucose in man. Am. J. Physiol. 1980, 238:E69-E82.
24. Imahori Y., Ueda S., Ohmori Y., Sakae K., Kusuki T., Kobayashi T., Takagaki M., Ono K., Ido T., Fujii R. Positron emission tomography-bases boron neutron capture therapy using borophenylalanine for high-grade gliomas: Part II. Clin. Cancer Res. 1998, 4:1833-1841.
25. Imahori Y., Ueda S., Ohmori Y., Sakae K., Kusuki T., Kobayashi T., Takagaki M., Ono K., Ido T., Fujii R. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: Part I. Clin. Cancer Res. 1998, 4:1825-1832.
26. Imahori Y., Ueda S., Ohmori Y., Kusuki T., Ono K., Fujii R., Ido T. Fluorine-18-Labeled Fluoroboronophenylalanine PET in patients with glioma. J. Nucl. Med. 1998, 39:325-333.
27. 18F)fluoro-d,l-phenylalanine: a target compound for PET and boron neutron capture therapy. Appl. Radiat. Isot. 1991, 42(4):325-328.
28. 18F]fluoro-l-phenylalanine. Melanoma Res. 1992, 2(3):171-179.
29. 18F)fluoromethyl-l-tyrosine as tumour imaging tracer by PET. Nucl. Med. Biol. 2004, 31:191-198.
30. Kabalka G.W., Nichols T.L., Smith G.T., Miller L.F., Khan M.K., Busse P.M. The use of positron emission tomography to develop boron neutron capture therapy treatment plans for metastatic malignant melanoma. J. Neurooncol. 2003, 62:187-195.
31. Kankaraanranta L., Seppala T., Koivunoro H., Saarilahti K., Atula T., Collan J., Salli E., Kortesniemi M., Uusi-Simola J., Makitie A., Seppanen M., Minn H., Kotiluoto P., Auterinen I., Savolainen S., Kouri M., Joensuu H. Boron neutron capture therapy in the treatment of locally recurred head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 2007, 69(2):475-482.
32. Kabalka G.W., Smith G.T., Dyke J.P., Reid W.S., Longford G.P., Roberts T.G., Reddy N.K., Buonocore E., Hubner K.F. Evaluation of fluoride-18-BPA-fructose for boron neutron capture treatment planning. J. Nucl. Med. 1997, 38:1762-1767.
33. Kato I., Ono K., Sakurai Y., Ohmae M., Maruhashi A., Imahori Y., Kirihatafa M., Nakazawa M., Yura Y. Effectiveness of BNCTfor recurrent head and neck malignancies. Appl. Radiat. Isot. 2004, 61:1069-1073.
34. Kouri M., Kankaraanta L., Seppala T., Tervo L., Rasilainen M., Minn H., Eskola O., Vahatalo J., Pateau A., Savolainen S., Auterinen I., Jaaskelainen J., Joensuu H. Undifferentiated sinosal carcinoma may respond to single-fraction boron neutron capture therapy. Radiother. Oncol. 2004, 72:83-85.
35. Mehrkens J.H., Popperi G., Rachiger W., Herms J., Seelos K., Tatsch K., Tonn J.C., Kreth F.W. The positive predicitive value of O-(2-(18)fluoroethyl)-l-tyrosine (FET) PET in the diagnosis of a glioma recurrence after multimodal treatment. J. Neurooncol. 2008, 88(1):27-35.
36. 18F]fluoroethyl)-l-tyrosine in an experimental animal model of F98 glioma for BNCT. Appl. Radiat. Isot. 2011, 69(12):1717-1720.
37. 18F-DOPA analogue. J. Neurooncol. 1997, 33:163-169.
38. Miyatake S., Kawabata S., Kajimoto Y., Aoki A., Yokoyama K., Yamada M., Kuroiwa T., Tsuji M., Imahori Y., Kirihata M., Sakurai Y., Masunaga S., Nagata K., Maruhashi A., Ono K. Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages. J. Neurosurg. 2005, 103(6):1000-1009.
39. Miyatake S., Tamura Y., Kawabata S., Iida K., Kuroiwa T., Ono K. Boron neutron capture therapy for malignant tumours related to meningiomas. Neurosurgery 2007, 61:82-91.
40. Nariai T., Ishiwata K., Kimura Y., Inaji M., Momose T., Yamamoto T., Matsumura A., Ishii K., Ohno K.P.E.T. pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma. Appl. Radiat. Isot. 2009.
41. Nichols T.L., Kabalka G.W., Miller L.F., Khan M.K., Smith G.T. Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled borophenylalanine and positron emission tomography. Med. Phys. 2002, 29(10):2351-2358.
42. Ochsner M. Photophysical and photobiological processes in photodynamic therapy of tumours. J. Photochem. Photobiol., B 1997, 39:1-18.
43. Otsuka S., Tamiya T., Ono Y., Michiue H., Kurozumi K., Daido S., Kambara H., Date I., Ohmoto T. The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. J. Neurooncol. 2004, 70(3):349-357.
44. Pisarev M.A., Dagraso M.A., Juneval G.J. Boron neutron capture therapy in cancer: pas, present and future. Arq. Bras. Endocrinol. Metab. 2007, 51(5):852-856.
45. 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom study at high magnetic field. Phys. Med. Biol. 2006, 51:3141-3154.
46. 19)F-labelled borophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT). Phys. Med. Biol. 2008, 53(23):6979-6989.
47. Reddi E., Ceccon M., Valduga G., Jori G., Bommer J.C., Elisei F., Mazzucato U. Photophysical properties of meso-substituted cationic porphyrins. Photochem. Photobiol. Sci. 2000, 75:462-470.
48. Ricchelli F. Photophysical properties of porphyrins in biological membranes. J. Photochem. Photobiol., B 1995, 29:109-118.
49. Singhal T., Narayanan T., Jain V., Mukherjee J., Mantil J. 11C-l-methionine positron emission tomography in the clinical management of cerebral gliomas. Mol. Imag. Biol. 2008, 10(1):1-18.
50. Snyder H.R., Reedy A.J., Lennarz W.J. Synthesis of aromatic boronic acids, aldehydo boronic acids and boronic acid analog tyrosine. J. Am. Chem. Soc. 1958, 80:835-838.
51. Soloway H.R., Hatanaka H., Davis M.A. Penetration of the brain and brain tumor. VII. Tumor-binding sulphydryl boron compounds. J. Med. Chem. 1967, 10:714.
52. Soncin M., Friso E., Jori G., Hao E., Vicente M.G.H., Miotto G., Colautti P., Moro D., Esposito J., Rosi G., Fabris C. Tumor-localizing and radiosensitizing properties of mesotetra(4-nido-carboranylphenyl)porphyrin (H2TCP). J. Porphyrins phtalocianine 2008, 12:866-873.
53. Takahashi Y., Imahori Y., Mineura K. Prognostic and therapeutic indicator of fluoroboronophenylalanine positron emission tomography in patients with gliomas. Clin. Cancer Res. 2003, 9:5888-5895.
54. Van Lier J.E., Spikes J.D. 1989. The chemistry, photophysics and photosensitising properties of phtalocianine. In: G. Bock and S. Harnett (Eds.), Photosensitising Compounds: their Chemistry, Biology and Clinical Use. Ciba Foundation Symposium, 146, pp.17-26.
55. 18F-fluro-l-phenylalanine-Fructose as a probe for boron neuttron capture therapy in a glioma-bearing rat model. J. Nucl. Med. 2004, 45(2):302-308.
56. 18F)fluoroethyl)-l-tyrosine and l-(methyl-11C)methionine uptake in brain tumors: initial results of a comparative study. Eur. J. Nucl. Med. 2000, 27:542-549.
57. Wittig A., Sauerwein W., Coderre J.A. Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro. Radiat. Res. 2000, 153(2):173-180.
58. Wittig A., Michel J., Mossc R.L., Stecher-Rasmussen F., Arlinghaus H.F., Bendel P., Mauri P.L., Altieri S., Hilger R., Salvadori P.A., Menichetti L., Zamenhofk R. Sauerwein WAG. Boron analysis and boron imaging in biological materials for boron neutron capture therapy (BNCT). Crit. Rev. Oncol. Hematol. 2008, 68:66-90.
59. Wyss M.T., Hofer S., Hefti M., Bartschi E., Uhlmann C., Treyer V., Roelcke U. Spatial heterogeneity of low-grade gliomas at the capillary level: a PET study on tumor blood flow and amino acid uptake. J. Nucl. Med. 2007, 48:1047-1052.
60. Zanoni L., Cerci J., Fanti S. Use of PET/CT to evaluate response to therapy in lymphoma. Q. J. Nucl. Med. Mol. Imaging 2011, 55:633-647.