Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3258-3262

  Hattori, Yoshihide ^a   Asano, Tomoyuki ^b   Niki, Yoko ^c   Kondoh, Hirofumi ^c   Kirihata, Mitsunori ^b   Yamaguchi, Yoshihiro ^a   Wakamiya, Tateaki ^a  

^a KINKI UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

^c Bio Research Inc   (Japan)

Author keywords

4 (10B)Borono 2,6 difluorophenyl alanine; 4 (10B)Borono 2,6 difluorophenyl alaninol; Boron neutron capture therapy; Magnetic resonance imaging

Indexed keywords

4 BORONO 2,6 DIFLUOROBENZYL ALCOHOL TERT BUTYLDIMETHYLSILYL ETHER B 10; 4 BORONO 2,6 DIFLUOROBENZYLBROMIDE B 10; BETA [4 BORONO 2,6 DIFLUOROPHENYL 1]ALANINOL B 10; BETA [4 BORONO 2,6 DIFLUOROPHENYL]ALANINE B 10; BETA [4 BORONO 2,6 DIFLUOROPHENYL]ALANINOL B 10; BETA [4 BORONO 2,6 DILFUOROPHENYL]ALANINE B 10; BETA [4 BORONOPHENYL]ALANINE B 10; BETA [4 BORONOPHENYL]ALANINOL B 10; BORON 10; FLUORINE; N ALPHA TERT BUTOXYCARBONYL BETA [4 BORONO 2,6 DIFLUOROPHENYL]ALANINE B 10; N ALPHA TERT BUTOXYCARBONYL Y3 [4 BORONO 2,6 DIFLUOROPHENYL]ALANINOL B 10; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATOM; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTERNALIZATION; NEUTRON CAPTURE THERAPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; TUMOR CELL;

ANIMALS; BORON; BORON NEUTRON CAPTURE THERAPY; BORONIC ACIDS; CELL LINE, TUMOR; CELLS, CULTURED; CONTRAST MEDIA; FLUORINE; HELA CELLS; HUMANS; ISOTOPES; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; NEOPLASMS; PHENYLALANINE; RATS;

ANIMALIA;

EID: 33645889996     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.062     Document Type: Article

References (12)

1. Sassa T., Suhara T., Ikehira H., Obata T., Griard F., Tanada S., and Okubo Y. Psychiatry Clin. Neurosci. 56 (2002) 637
2. Higuchi M., Iwata N., Matsuba Y., Sato K., Sasamoto K., and Saido C.T. Nat. Neurosci. 8 (2005) 527
3. Hattori Y., Yamaguchi Y., Yamamoto H., Asano T., Kirihata M., Takagaki M., and Wakamiya T. Peptide Sci. 2004 (2005) 411
4. Soloway H.A., Tjarks W., Barnum A.B., Rong F., Barth F.R., Codogni M.I., and Wilson J.G. Chem. Rev. 98 (1998) 1515
5. Barth R.F., Yang W., Adams D.M., Rotaru J.H., Shukla S., Sekido M., Tjarks W., Frestermaker R.A., Ciesielski M., Nowrocky M.M., and Coderre J.A. Cancer Res. 62 (2002) 3159
6. Kato I., Ono K., Sakurai Y., Ohmae M., Maruhashi A., Imahori Y., Kirihata M., Nakazawa M., and Yura Y. Appl. Radiat. Isot. 61 (2004) 1083
7. Snyder H.R., Reedy A.J., and Lennarz W.J. J. Am. Chem. Soc. 80 (1958) 835
8. Masunaga S., Ono K., Kirihata M., Takagaki M., Sakurai Y., Kinashi Y., Kobayashi T., Nagasawa H., Uto Y., and Hori H. Jpn. J. Cancer Res. 92 (2001) 996
9. Mongin F., and Schlosser M. Tetrahedron Lett. 37 (1996) 6551
10. Matondo H., Souirti S., and Baboulene M. Synth. Commun. 33 (2003) 795
11. Naruta Y., Uno H., and Maruyama K. Tetrahedron Lett. 22 (1981) 5221
12. Kabalka W.G. Synthesis 4 (1990) 299