Neutron autoradiography imaging of selective boron uptake in human metastatic tumours

Applied Radiation and Isotopes

Volumn 66, Issue 12, 2008, Pages 1850-1855

  Altieri, S ^a,b   Bortolussi, S ^a,b   Bruschi, P ^a   Chiari, P ^a   Fossati, F ^a   Stella, S ^a   Prati, U ^c   Roveda, L ^c   Zonta, A ^a   Zonta, C ^a   Ferrari, C ^a   Clerici, A ^a   Nano, R ^a   Pinelli, T ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b INFN SEZIONE DI PAVIA   (Italy)

^c Oncologic Surgery   (Italy)

Author keywords

BNCT; Boron imaging; Liver metastases; Neutron radiography

Indexed keywords

BORON; BORON COMPOUNDS; RADIOGRAPHY;

BNCT; BORON IMAGING; LIVER METASTASES; NEUTRON RADIOGRAPHY;

TUMORS;

BORON 10; BORON PHENYLALANINE; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METASTASIS; MORPHOLOGY; NEUTRON AUTORADIOGRAPHY; NEUTRON CAPTURE THERAPY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TUMOR CELL;

AUTORADIOGRAPHY; BORON; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; NEUTRONS; TISSUE DISTRIBUTION;

EID: 53549113611     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.05.007     Document Type: Article

References (31)

1. Alfassi Z.B., and Probst T.U. On the calibration curve for determination of boron in tissue by quantitative neutron capture radiography. Nucl. Instrum. Methods A 428 (1999) 502-507
2. Barth R.F., Coderre J.A., Vicente M.G.H., and Blue T.E. Boron neutron capture therapy of cancer: current status and future prospects. Clin. Cancer Res. 3987 (2005) 11
3. Bennett B.D., Mumford-Zisk J., Coderre J.A., and Morrison G.H. Subcellular localization of p-boronophenylalanine-delivered boron-10 in the rat 9L gliosarcoma: cryogenic preparation in vitro and in vivo. Radiat. Res. 140 (1994) 72-78
4. Bortolussi S., and Altieri S. Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Med. Phys. 34 (2007) 4700-4705
5. Chanana A.D., Capala J., Chadha M., et al. Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies. Neurosurgery 44 (1999) 1182-1193
6. Chiaraviglio D., De Grazia F., Zonta A., Altieri S., Braghieri A., Fossati F., Pedroni P., Pinelli T., Perotti A., Specchiarello, Perlini G., and Rief H. Evaluation of selective boron absorption in liver tumors. Strahlenther. Onkol. 165 2/3 (1989) 170-172
7. Coderre J.A., and Morris G.M. The radiation biology of boron neutron capture therapy. Radiat. Res. 151 1 (1999) 1-18
8. Database of Prompt Gamma Rays from Slow Neutron Capture for Elemental Analysis STI/PUB/1263, International Atomic Energy Agency, Vienna, 2007.
9. Edwards L.C. Autoradiography by neutron activation: the cellular distribution of 10B in the transplanted mouse brain tumor. Int. J. Appl. Radiat. Isot. 1 (1956) 184-190
10. Enge W., Grabisch K., Beaujean R., and Bartholoma K.-P. Etching behaviour of cellulose nitrate plastic detector under various etching conditions. Nucl. Instrum. Methods 115 (1974) 263-270
11. Evans S., and Krahenbuhl U. Improved boron determination in biological material by inductively coupled plasma mass spectrometry. J. Anal. Spectrom. 9 (1994) 1249-1253
12. 7Li reaction. Med. Phys. 13 (1986) 50-56
13. Farr L.E., Sweet W.H., Robertson J.S., Forster G.S., Locksley H.B., Sutherland D.L., Mendelsohn M.L., and Stickey E.E. Neutron capture therapy with Boron in the treatment of glioblastoma multiforme. Am. J. Roentgenol. 71 (1954) 279-291
14. Griffith, R.V., Tommasino, L., 1990. Etch track detectors in radiation dosimetry. In: Kenneth R. Kase, Bengt E. Bjarngard, Frank H. Attix (Eds.), The Dosimetry of Ionizing Radiation. vol. III. Academic Press, San Diego, California (Chapter 4).
15. Hatanaka H. Clinical experience of boron-neutron capture therapy forgliomas-a comparison with conventional chemo-immuno-radiotherapy. In: Hatanaka H. (Ed). Boron Neutron Capture Therapy for Tumours (1986), Nishimura Co., Niigata 349-379
16. Kiger III W.S., Micca P.L., Morris G.M., and Coderre J.A. Boron microquantification in oral muscosa and skin following administration of a neutron capture therapy agent. Radiat. Prot. Dosimetry 99 (2002) 409-412
17. Kiger III W.S., et al. Preliminary treatment planning and dosimetry for a clinical trial of neutron capture therapy using a fission converter epithermal neutron beam. Appl. Radiat. Isot. 61 (2004) 1075-1081
18. Kobayashi T., and Kanda K. Microanalysis system of ppm order b-10 concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry. Nucl. Instrum. Methods Phys. Res. 204 (1983) 525-531
19. Laakso J., Kulvik M., Ruokonen I., Vahatalo J., Zilliacus R., Farkkila M., et al. Atomic emission method for total boron in blood during neutron-capture therapy. Clin. Chem. 47 (2001) 1796-1803
20. Locher G.L. Biological effects and therapeutical possibilities of neutrons. Am. J. Roentgenol. Radium Ther. 36 (1936) 1-13
21. Matsumoto T., Aoki M., and Aizawa O. Phantom experiment and calculation for in vivo 10boron analysis by prompt gamma ray spectroscopy. Phys. Med. Biol. 36 (1991) 329-338
22. Nigg D.W. Computational dosimetry and treatment planning considerations for neutron capture therapy. J. Neurooncol. 62 (2003) 75-86
23. Palmer M.R., et al. Treatment planning and dosimetry for the Harvard-MIT phase, I clinical trial of cranial neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys. 53 (2002) 1361-1379
24. Pinelli T., Zonta A., Altieri S., Barni S., Braghieri A., Pedroni P., Bruschi P., Chiari P., Ferrari C., and Zonta C. TAOrMINA: from the first idea to the application to the human liver. In: Sauerwein W., Moss R., and Wittig A. (Eds). Research and Development in Neutron Capture Therapy (2002), Monduzzi Editore, Bologna 1065-1072
25. Probst T.U. Comparison of inductively coupled plasma atomic emission spectrometry and inductively coupled plasma mass spectrometry with quantitative neutron capture radiography for the determination of boron in biological samples from cancer therapy. J. Anal. A Spectrom. 12 (1997) 1115-1122
26. Riley K.J. An improved prompt gamma neutron activation analysis facility using a focused diffracted neutron beam. Nucl. Instrum. Methods Phys. Res. B 143 (1998) 414-421
27. Smith D.R., Chandra S., Coderre J.A., and Morrison G.H. Ion microscopy imaging of 10B from p-boronophenylalanine in a brain tumor model for boron neutron capture therapy. Cancer Res. 56 (1996) 4302-4306
28. Smith D., Chandra S., Barth R., Yang W., Joel D., and Coderre J. Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy. Cancer Res. 61 (2001) 8179-8187
29. Solares G.R., and Zamenhof R.G. A novel approach to the microdosimetry of neutron capture therapy, Part I: high-resolution quantitative autoradiography applied to microdosimetry in neutron capture therapy. Radiat. Res. 144 (1995) 50-58
30. Verbakel W.F.A.R. Boron concentrations in brain during boron neutron capture therapy: in vivo measurements from the phase I trial EORT 11961 using a gamma-ray telescope. Int. J. Radiat. Oncol. Biol. Phys. 55 3 (2003) 743-756
31. Zonta A., Prati U., Roveda L., Ferrari C., Zonta S., Clerici A.M., Zonta C., Pinelli T., Fossati F., Altieri S., Bortolussi S., Bruschi P., Nano R., Barni S., Chiari P., and Mazzini G. Clinical lessons from the 1st applications of BNCT on unresectable liver metastases. J. Phys.: Conf. Ser. 41 (2006) 484-495