In vivo 19F MRI and 19F MRS of 19F- labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT)

Physics in Medicine and Biology

Volumn 53, Issue 23, 2008, Pages 6979-6989

  Porcari, Paola ^a,b   Capuani, Silvia ^a,b   D'Amore, Emanuela ^c   Lecce, Mario ^d   La Bella, Angela ^a   Fasano, Fabrizio ^e   Campanella, Renzo ^f   Migneco, Luisa Maria ^a   Pastore, Francesco Saverio ^d   Maraviglia, Bruno ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^f UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMS; BORON; BORON COMPOUNDS; CIVIL AVIATION; IRRADIATION; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; NEUTRON IRRADIATION; NEUTRONS; PHARMACOKINETICS; RECONNAISSANCE AIRCRAFT; SIZE DISTRIBUTION;

BLOOD SAMPLES; BORON NEUTRON CAPTURE THERAPIES; GLIOMA MODELS; IN-VIVO; INVASIVE METHODS; OPTIMAL TIMINGS; SPATIAL DISTRIBUTION OF; SPATIAL DISTRIBUTIONS;

RESONANCE;

BORONOPHENYLALANINE F 19; FRUCTOSE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DISTRIBUTION; FLUORINE NUCLEAR MAGNETIC RESONANCE; GLIOMA; HUMAN; HUMAN CELL; MALE; NEUTRON CAPTURE THERAPY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; DEMOGRAPHY; FLUORINE RADIOISOTOPES; FRUCTOSE; GLIOMA; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEOPLASMS, EXPERIMENTAL; RATS; RATS, WISTAR;

EID: 58149216495     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/23/021     Document Type: Article

References (47)

1. Barth R F, Coderre J A, Vicente M G H and Blue T E 2005 Boron neutron capture therapy of cancer: current status and future prospects Clin. Cancer Res. 11 3987-4002
2. 11B NMR NMR Biomed. 18 74-82
3. 10B MRI Magn. Reson. Med. 46 13-7
4. 1H MRS and MRSI methods for the in vivo detection of boronophenylalnine Magn. Reson. Med. 53 1166-71
5. 10B NMR Med. Phys. 28 178-83
6. Bulte J W 2005 Hot spot MRI emerges from the background Nat. Biotechnol. 23 945-6
7. Burian J et al 2004 Proc. of the 11th World Congress on Neutron Capture Therapy (Boston, USA 11-15 October 2004) 27-32 Report on the first patient group of the phase I BNCT trial at the LVR-15 reactor
8. Busse P M et al 2003 A critical examination of the results from the Harvard-MIT NCT program phase I clinical trial of neutron capture therapy for intracranial disease J. Neurooncol. 62 111-21
9. Capala J et al 2003 Boron neutron capture therapy (BNCT) for glioblastoma multiforme: clinical studies in Sweden J. Neurooncol. 62 135-44
10. Chanana A D et al 1999 Boron neutron capture therapy for glioblastoma multiforme: interim results from the phaseI/II dose escalation studies Neurosurgery 44 1182-93
11. Coderre J A and Morris G M 1999 The radiation biology of boron neutron capture therapy Radiat. Res. 151 1-18
12. Coderre J A et al 1998 Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity Radiat. Res. 149 163-7
13. Coderre J A, Turcotte J C, Riley K J, Binns P J, Harling O K and Kiger W S 2003 Boron neutron capture therapy: cellular targeting of high linear energy transfer radiation Tech. Cancer Res. Treat. 2 355-75
14. Diaz A Z 2003 Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view J. Neurooncol. 62 101-9
15. Elowitz E H, Bergland R M, Coderre J A, Joel D D, Chandha M and Chanana A D 1998 Biodistribution of boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy Neurosurgery 42 463-9
16. Enriksson R, Capala J, Michanek A, Lindahl S K, Salford L G, Franzen L, Blomquist E, Westlin J E, Bergenheim A T and Swedish Brain Tumour Study Group 2008 Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA) Radiother. Oncol. 88 183-91
17. Hatanaka H and Nakagawa Y 1994 Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy Int. J. Radiat. Oncol. Biol. Phys 28 1061-6
18. 10B atoms in a single molecule for the application to MRI and BNCT Bioorg. Med. Chem. 14 3258-62
19. Hattory Y, Yamamoto H, Ando H, Kondoh H, Asano T, Kirihata M, Yamaguchi Y and Wakamiya T 2007 Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative Bioorg. Med. Chem. 15 2198-205
20. 1H MRI detection of amyloid beta plaques in vivo Natl Neurosci. 8 527-33
21. 18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain barrier disruption J. Nucl. Med. 46 1858-65
22. Imahori Y, Ueda S, Ohmori Y, Kusuki T, Ono K, Fujii R and Ido T 1998 Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma J. Nucl. Med. 39 325-33
23. International Atomic Energy Agency IAEA 2001 Current status of neutron capture therapy (Vienna: IAEA Press) IAEA-TECDOC-1223
24. Joensuu H et al 2003 neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine J. Neurooncol. 62 123-34
25. Kabalka G W, Smith G T, Dyke G P, Reid W S, Longford C P, Roberts T G, Reddy N K, Bonocore E and Hubner K F 1997 Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning J. Nucl. Med. 38 1762-7
26. Kabalka W G, Nichols T L, Smith G T, Miller L F, Khan M K and Busse P M 2003 The use of positron emission tomography to develop boron neutron capture therapy treatment plans for metastatic malignant melanoma J. Neurooncol. 62 187-95
27. Kageji T, Nagahiro S, Kitamura K, Nakagawa Y, Hatanaka H, Haritz D, Grochulla F, Haselsberger K and Gabel D 2001 Optimal timing of neutron irradiation for boron neutron capture therapy after intravenous infusion of sodium borocaptate in patients with glioblastoma Int. J. Radiat. Oncol. Biol. Phys 51 120-30
28. Laakso J, Kulvik M, Ruokonen I, Vahatalo J, Zilliacus R, Farkkila M and Kallio M 2001 Atomic emission method for total boron in blood during neutron capture therapy Clin. Chem. 47 1796-803
29. Miyatake S, Tamura Y, Kawabata S, Iida K, Kuroiwa T and Ono K 2007 Boron neutron capture therapy for malignant tumors related to meningiomas Neurosurgery 61 82-90
30. 19F MRI probe to detect protease activity J. Am. Chem. Soc. 130 794-5
31. Nakagawa Y and Hatanaka H 1997 Boron neutron capture therapy. Clinical brain tumor studies J. Neurooncol. 33 105-15
32. Nichols T L, Kabalka G W, Miller L F, Khan M K and Smith G T 2002 Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled boronophenylalanine and positron emission tomography Med. Phys. 29 2351-8
33. Palmer M R, Goorley J T, Kiger W S, Busse P M, Riley J K, Harling O K and Zamenhof R G 2002 Treatment planning and dosimetry for the Harvard-MIT Phase I clinical trial of cranial neutron capture therapy Int. J. Radiat. Oncol. Biol. Phys. 53 1361-79
34. Pisarev M A, Dagrosa M A and Juvenal G J 2007 Boron neutron capture therapy in cancer: past, present and future Arq. Bras. Endocrinol. Metab. 51 852-6
35. 10B-enriched p-boronophenylalanine- fructose complex to optimize boron neutron capture therapy: phantom study at high magnetic field Phys. Med. Biol. 51 3141-54
36. 10B in blood after BPA-fructose complex infusion Phys. Med. Biol. 47 737-45
37. 10B concentration after BPA-fructose complex infusion in patient during epithermal neutron irradiation in BNCT Int. J. Radiat. Oncol. Biol. Phys. 48 1145-54
38. Sauerwein W 1993 Principles and history of neutron capture therapy Strahlenther. Onkol. 169 1-6
39. Soloway A H, Hatanaka H and Davis M A 1967 Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds J. Med. Chem. 10 714-7
40. Sweet W H 1997 Early history of development of boron neutron capture therapy of tumors J. Neurooncol. 33 19-26
41. Van Rij C M, Wilhelm A J, Sauerwein W A G and Van Loenen A C 2005 Boron neutron capture therapy for glioblastoma multiforme Pharm. World Sci. 27 92-95
42. 18F-Fluoro-L- Phenylalanine-Fructose as a probe for boron neutron capture therapy in a glioma-bearing rat model J. Neurooncol. 45 302-8
43. Wittig A, Michel J, Moss R L, Stecher-Rasmussen F, Arlinghaus H F, Bendel P, Mauri P L, Altieri S, Hilger R, Salvadori P A, Menichetti L, Zamenhof R and Sauerwein WAG 2008 Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy Crit. Rev. Oncol. Hematol 68 66-90
44. Wittig A, Sauerwein W A and Coderre J A 2000 Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro Radiat. Res. 153 173-80
45. Yamamoto T, Nakai K and Matsumura A 2008 Boron neutron capture therapy for glioblastoma Cancer Lett. 262 143-52
46. Yoshino K, Suzuki A, Mori Y, Kakiana H, Honda C, Mishima Y, Kobayashi T and Kanda K 1989 Improvement of solubility of p-boronophenylalanine by complex formation with monosaccharides Strahlenther. Onkol. 165 127-9
47. Zuo C S, Prasad P V, Busse P, Tang L and Zamenhof R G 1999 Proton nuclear magnetic resonance measurement of p-boronophenylalnine (BPA): a therapeutic agent for boron neutron capture therapy Med. Phys. 26 1230-6