Good codons, bad transcript: Large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

Molecular Biology and Evolution

Volumn 30, Issue 3, 2013, Pages 549-560

  Agashe, Deepa ^a,d   Martinez Gomez, N Cecilia ^b   Drummond, D Allan ^c,e   Marx, Christopher J ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HARVARD UNIVERSITY   (United States)

^d TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

codon usage bias; codon usage evolution; fitness; Methylobacterium extorquens; ribosome sequestration

Indexed keywords

ENZYME;

ALLELE; ARTICLE; CODON; CODON USAGE; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; METHYLOBACTERIUM EXTORQUENS; NONHUMAN; PROTEIN MOTIF; PROTEIN SECRETION; RIBOSOME;

BACTERIAL PROTEINS; CARBON-NITROGEN LIGASES; CODON; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC FITNESS; METHYLOBACTERIUM EXTORQUENS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 84873601673     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mss273     Document Type: Article

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