메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages

Insulin Therapy for Pre-Hyperglycemic Beta-Cell Endoplasmic Reticulum Crowding

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN DETEMIR; PROINSULIN;

EID: 84873599585     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054351     Document Type: Article
Times cited : (14)

References (54)
  • 1
    • 7444234167 scopus 로고    scopus 로고
    • Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function
    • Li Y, Xu W, Liao Z, Yao B, Chen X, et al. (2004) Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 27: 2597-2602.
    • (2004) Diabetes Care , vol.27 , pp. 2597-2602
    • Li, Y.1    Xu, W.2    Liao, Z.3    Yao, B.4    Chen, X.5
  • 2
    • 2342587418 scopus 로고    scopus 로고
    • Short-term intensive insulin therapy in newly diagnosed type 2 diabetes
    • Ryan EA, Imes S, Wallace C, (2004) Short-term intensive insulin therapy in newly diagnosed type 2 diabetes. Diabetes Care 27: 1028-1032.
    • (2004) Diabetes Care , vol.27 , pp. 1028-1032
    • Ryan, E.A.1    Imes, S.2    Wallace, C.3
  • 3
    • 0041523870 scopus 로고    scopus 로고
    • Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients
    • Alvarsson M, Sundkvist G, Lager I, Henricsson M, Berntorp K, et al. (2003) Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients. Diabetes Care 26: 2231-2237.
    • (2003) Diabetes Care , vol.26 , pp. 2231-2237
    • Alvarsson, M.1    Sundkvist, G.2    Lager, I.3    Henricsson, M.4    Berntorp, K.5
  • 4
    • 56149118663 scopus 로고    scopus 로고
    • Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy
    • Chen HS, Wu TE, Jap TS, Hsiao LC, Lee SH, et al. (2008) Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy. Diabetes Care 31: 1927-1932.
    • (2008) Diabetes Care , vol.31 , pp. 1927-1932
    • Chen, H.S.1    Wu, T.E.2    Jap, T.S.3    Hsiao, L.C.4    Lee, S.H.5
  • 5
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
    • Weng J, Li Y, Xu W, Shi L, Zhang Q, et al. (2008) Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 371: 1753-1760.
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3    Shi, L.4    Zhang, Q.5
  • 6
    • 0034485456 scopus 로고    scopus 로고
    • Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus
    • Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G, (2000) Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus. Acta Diabetol 37: 125-129.
    • (2000) Acta Diabetol , vol.37 , pp. 125-129
    • Bo, S.1    Cavallo-Perin, P.2    Gentile, L.3    Repetti, E.4    Pagano, G.5
  • 7
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group
    • The writing team of the DCCT
    • The writing team of the DCCT (1998) Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group. Ann Intern Med 128: 517-523.
    • (1998) Ann Intern Med , vol.128 , pp. 517-523
  • 8
    • 61849139579 scopus 로고    scopus 로고
    • Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients
    • Panero F, Novelli G, Zucco C, Fornengo P, Perotto M, et al. (2009) Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients. Diabetes Care 32: 301-305.
    • (2009) Diabetes Care , vol.32 , pp. 301-305
    • Panero, F.1    Novelli, G.2    Zucco, C.3    Fornengo, P.4    Perotto, M.5
  • 9
    • 0036372339 scopus 로고    scopus 로고
    • Relationship between autonomic cardiac activity, beta-cell function, anthropometrics and metabolic indices in type II diabetics
    • Manzella D, Carbonella M, Ragno E, Passariello N, Grella R, et al. (2002) Relationship between autonomic cardiac activity, beta-cell function, anthropometrics and metabolic indices in type II diabetics. Clin Endocrinol (Oxf) 57: 259-264.
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 259-264
    • Manzella, D.1    Carbonella, M.2    Ragno, E.3    Passariello, N.4    Grella, R.5
  • 10
    • 0038004645 scopus 로고    scopus 로고
    • Residual C-peptide secretion and endothelial function in patients with Type II diabetes
    • Manzella D, Ragno E, Abbatecola AM, Grella R, Paolisso G, (2003) Residual C-peptide secretion and endothelial function in patients with Type II diabetes. Clin Sci (Lond) 105: 113-118.
    • (2003) Clin Sci (Lond) , vol.105 , pp. 113-118
    • Manzella, D.1    Ragno, E.2    Abbatecola, A.M.3    Grella, R.4    Paolisso, G.5
  • 11
    • 33746377965 scopus 로고    scopus 로고
    • Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose
    • Abdul-Ghani MA, Tripathy D, DeFronzo RA, (2006) Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 29: 1130-1139.
    • (2006) Diabetes Care , vol.29 , pp. 1130-1139
    • Abdul-Ghani, M.A.1    Tripathy, D.2    DeFronzo, R.A.3
  • 13
    • 79951706170 scopus 로고    scopus 로고
    • Prevalence, diagnosis, and treatment of impaired fasting glucose and impaired glucose tolerance in nondiabetic U.S. adults
    • Karve A, Hayward RA, (2010) Prevalence, diagnosis, and treatment of impaired fasting glucose and impaired glucose tolerance in nondiabetic U.S. adults. Diabetes care 33: 2355-2359.
    • (2010) Diabetes Care , vol.33 , pp. 2355-2359
    • Karve, A.1    Hayward, R.A.2
  • 14
    • 70350310991 scopus 로고    scopus 로고
    • Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes
    • Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y, et al. (2009) Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes Obes Metab 11Suppl 4: 65-81.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 65-81
    • Jonas, J.C.1    Bensellam, M.2    Duprez, J.3    Elouil, H.4    Guiot, Y.5
  • 15
    • 0023940801 scopus 로고
    • Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy
    • Leahy JL, Bonner-Weir S, Weir GC, (1988) Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 81: 1407-1414.
    • (1988) J Clin Invest , vol.81 , pp. 1407-1414
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 16
    • 0014802883 scopus 로고
    • Studies in the diabetic mutant mouse. 3. Physiological factors associated with alterations in beta cell proliferation
    • Chick WL, Like AA, (1970) Studies in the diabetic mutant mouse. 3. Physiological factors associated with alterations in beta cell proliferation. Diabetologia 6: 243-251.
    • (1970) Diabetologia , vol.6 , pp. 243-251
    • Chick, W.L.1    Like, A.A.2
  • 17
    • 0025887828 scopus 로고
    • No glucotoxicity after 53 hours of 6.0 mmol/l hyperglycaemia in normal man
    • Flax H, Matthews DR, Levy JC, Coppack SW, Turner RC, (1991) No glucotoxicity after 53 hours of 6.0 mmol/l hyperglycaemia in normal man. Diabetologia 34: 570-575.
    • (1991) Diabetologia , vol.34 , pp. 570-575
    • Flax, H.1    Matthews, D.R.2    Levy, J.C.3    Coppack, S.W.4    Turner, R.C.5
  • 18
    • 79953735981 scopus 로고    scopus 로고
    • Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure
    • Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, et al. (2011) Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia 54: 605-616.
    • (2011) Diabetologia , vol.54 , pp. 605-616
    • Kluth, O.1    Mirhashemi, F.2    Scherneck, S.3    Kaiser, D.4    Kluge, R.5
  • 20
    • 0014799716 scopus 로고
    • Studies in the diabetic mutant mouse. II. Electron microscopy of pancreatic islets
    • Like AA, Chick WL, (1970) Studies in the diabetic mutant mouse. II. Electron microscopy of pancreatic islets. Diabetologia 6: 216-242.
    • (1970) Diabetologia , vol.6 , pp. 216-242
    • Like, A.A.1    Chick, W.L.2
  • 21
    • 35848963392 scopus 로고    scopus 로고
    • The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    • Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, et al. (2007) The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50: 2486-2494.
    • (2007) Diabetologia , vol.50 , pp. 2486-2494
    • Marchetti, P.1    Bugliani, M.2    Lupi, R.3    Marselli, L.4    Masini, M.5
  • 22
    • 0037312881 scopus 로고    scopus 로고
    • Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
    • Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, et al. (2003) Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52: 409-416.
    • (2003) Diabetes , vol.52 , pp. 409-416
    • Izumi, T.1    Yokota-Hashimoto, H.2    Zhao, S.3    Wang, J.4    Halban, P.A.5
  • 24
    • 77955383087 scopus 로고    scopus 로고
    • PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway
    • Gupta S, McGrath B, Cavener DR, (2010) PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway. Diabetes 59: 1937-1947.
    • (2010) Diabetes , vol.59 , pp. 1937-1947
    • Gupta, S.1    McGrath, B.2    Cavener, D.R.3
  • 25
    • 79952586301 scopus 로고    scopus 로고
    • Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells
    • Hatanaka M, Tanabe K, Yanai A, Ohta Y, Kondo M, et al. (2011) Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hum Mol Genet 20: 1274-1284.
    • (2011) Hum Mol Genet , vol.20 , pp. 1274-1284
    • Hatanaka, M.1    Tanabe, K.2    Yanai, A.3    Ohta, Y.4    Kondo, M.5
  • 26
    • 34250655269 scopus 로고    scopus 로고
    • The new type 2 diabetes gene TCF7L2
    • Florez JC, (2007) The new type 2 diabetes gene TCF7L2. Curr Opin Clin Nutr Metab Care 10: 391-396.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 391-396
    • Florez, J.C.1
  • 27
    • 43249095915 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    • Stancakova A, Pihlajamaki J, Kuusisto J, Stefan N, Fritsche A, et al. (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93: 1924-1930.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1924-1930
    • Stancakova, A.1    Pihlajamaki, J.2    Kuusisto, J.3    Stefan, N.4    Fritsche, A.5
  • 28
    • 79959751832 scopus 로고    scopus 로고
    • A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases
    • Sandefur CI, Schnell S, (2011) A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases. Biophys J 100: 1864-1873.
    • (2011) Biophys J , vol.100 , pp. 1864-1873
    • Sandefur, C.I.1    Schnell, S.2
  • 29
    • 58549117847 scopus 로고    scopus 로고
    • Dilation of the endoplasmic reticulum in beta cells due to molecular overcrowding? Kinetic simulations of extension limits and consequences on proinsulin synthesis
    • Despa F, (2009) Dilation of the endoplasmic reticulum in beta cells due to molecular overcrowding? Kinetic simulations of extension limits and consequences on proinsulin synthesis. Biophys Chem 140: 115-121.
    • (2009) Biophys Chem , vol.140 , pp. 115-121
    • Despa, F.1
  • 30
    • 80052843122 scopus 로고    scopus 로고
    • In vivo misfolding of proinsulin below the threshold of frank diabetes
    • Hodish I, Absood A, Liu L, Liu M, Haataja L, et al. (2011) In vivo misfolding of proinsulin below the threshold of frank diabetes. Diabetes 60: 2092-2101.
    • (2011) Diabetes , vol.60 , pp. 2092-2101
    • Hodish, I.1    Absood, A.2    Liu, L.3    Liu, M.4    Haataja, L.5
  • 31
    • 0036318291 scopus 로고    scopus 로고
    • The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology
    • Junger E, Herberg L, Jeruschke K, Leiter EH, (2002) The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology. Lab Invest 82: 843-853.
    • (2002) Lab Invest , vol.82 , pp. 843-853
    • Junger, E.1    Herberg, L.2    Jeruschke, K.3    Leiter, E.H.4
  • 32
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka M, Kayo T, Ikeda T, Koizumi A, (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46: 887-894.
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 34
    • 0024448693 scopus 로고
    • The genetics of diabetes susceptibility in mice
    • Leiter EH, (1989) The genetics of diabetes susceptibility in mice. FASEB J 3: 2231-2241.
    • (1989) FASEB J , vol.3 , pp. 2231-2241
    • Leiter, E.H.1
  • 35
    • 73649115634 scopus 로고    scopus 로고
    • Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
    • Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, et al. (2010) Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem 285: 685-694.
    • (2010) J Biol Chem , vol.285 , pp. 685-694
    • Hodish, I.1    Liu, M.2    Rajpal, G.3    Larkin, D.4    Holz, R.W.5
  • 36
    • 0014805928 scopus 로고
    • Studies in the diabetic mutant mouse. I. Light microscopy and radioautography of pancreatic islets
    • Like AA, Chick WL, (1970) Studies in the diabetic mutant mouse. I. Light microscopy and radioautography of pancreatic islets. Diabetologia 6: 207-215.
    • (1970) Diabetologia , vol.6 , pp. 207-215
    • Like, A.A.1    Chick, W.L.2
  • 37
    • 56049088271 scopus 로고    scopus 로고
    • Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c
    • Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, et al. (2008) Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c. Am J Physiol Endocrinol Metab 295: E981-986.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Han, B.G.1    Hao, C.M.2    Tchekneva, E.E.3    Wang, Y.Y.4    Lee, C.A.5
  • 39
    • 0036182685 scopus 로고    scopus 로고
    • Heterogeneous cell renewal of pancreas in mice: ((3)H)-thymidine autoradiographic investigation
    • Magami Y, Azuma T, Inokuchi H, Moriyasu F, Kawai K, et al. (2002) Heterogeneous cell renewal of pancreas in mice: ((3)H)-thymidine autoradiographic investigation. Pancreas 24: 153-160.
    • (2002) Pancreas , vol.24 , pp. 153-160
    • Magami, Y.1    Azuma, T.2    Inokuchi, H.3    Moriyasu, F.4    Kawai, K.5
  • 41
    • 0035129172 scopus 로고    scopus 로고
    • Compensatory responses in mice carrying a null mutation for Ins1 or Ins2
    • Leroux L, Desbois P, Lamotte L, Duvillie B, Cordonnier N, et al. (2001) Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 50Suppl 1: S150-153.
    • (2001) Diabetes , vol.50
    • Leroux, L.1    Desbois, P.2    Lamotte, L.3    Duvillie, B.4    Cordonnier, N.5
  • 42
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D, (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332.
    • (2000) Nat Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 43
    • 0016139325 scopus 로고
    • The interactions of proinsulin with insulin receptors on the plasma membrane of the liver
    • Freychet P, (1974) The interactions of proinsulin with insulin receptors on the plasma membrane of the liver. J Clin Invest 54: 1020-1031.
    • (1974) J Clin Invest , vol.54 , pp. 1020-1031
    • Freychet, P.1
  • 44
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, et al. (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289: 76-79.
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3    Dietz, W.H.4    Vinicor, F.5
  • 45
    • 12244299450 scopus 로고    scopus 로고
    • beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
    • Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, et al. (2005) beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 90: 493-500.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 493-500
    • Ferrannini, E.1    Gastaldelli, A.2    Miyazaki, Y.3    Matsuda, M.4    Mari, A.5
  • 46
    • 0036344439 scopus 로고    scopus 로고
    • Glucose metabolism in lean patients with mild type 2 diabetes mellitus: evidence for insulin-sensitive and insulin-resistant variants
    • Garcia-Estevez DA, Araujo-Vilar D, Saavedra-Gonzalez A, Fiestras-Janeiro G, Cabezas-Cerrato J, (2002) Glucose metabolism in lean patients with mild type 2 diabetes mellitus: evidence for insulin-sensitive and insulin-resistant variants. Metabolism 51: 1047-1052.
    • (2002) Metabolism , vol.51 , pp. 1047-1052
    • Garcia-Estevez, D.A.1    Araujo-Vilar, D.2    Saavedra-Gonzalez, A.3    Fiestras-Janeiro, G.4    Cabezas-Cerrato, J.5
  • 47
    • 79959449171 scopus 로고    scopus 로고
    • Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium
    • Boffetta P, McLerran D, Chen Y, Inoue M, Sinha R, et al. (2011) Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium. PLoS One 6: e19930.
    • (2011) PLoS One , vol.6
    • Boffetta, P.1    McLerran, D.2    Chen, Y.3    Inoue, M.4    Sinha, R.5
  • 50
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, et al. (2006) Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 355: 2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3    Herman, W.H.4    Holman, R.R.5
  • 51
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • Gerstein HC, Bosch J, Dagenais GR, Diaz R, Jung H, et al. (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367: 319-328.
    • (2012) N Engl J Med , vol.367 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3    Diaz, R.4    Jung, H.5
  • 52
    • 0030747586 scopus 로고    scopus 로고
    • Failure of high-dose insulin treatment to increase beta-cell insulin content in diabetic non obese diabetic (NOD) mice
    • Bache I, Jorgensen KH, Buschard K, (1997) Failure of high-dose insulin treatment to increase beta-cell insulin content in diabetic non obese diabetic (NOD) mice. Diabetes Res Clin Pract 37: 9-14.
    • (1997) Diabetes Res Clin Pract , vol.37 , pp. 9-14
    • Bache, I.1    Jorgensen, K.H.2    Buschard, K.3
  • 53
    • 84856735931 scopus 로고    scopus 로고
    • Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2(C95S))
    • Kautz S, van Burck L, Schuster M, Wolf E, Wanke R, et al. (2012) Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2(C95S)). Diabetologia 55: 382-391.
    • (2012) Diabetologia , vol.55 , pp. 382-391
    • Kautz, S.1    van Burck, L.2    Schuster, M.3    Wolf, E.4    Wanke, R.5
  • 54
    • 80054975337 scopus 로고    scopus 로고
    • Insulin improves beta-cell function in glucose-intolerant rat models induced by feeding a high-fat diet
    • Li HQ, Wang BP, Deng XL, Zhang JY, Wang YB, et al. (2011) Insulin improves beta-cell function in glucose-intolerant rat models induced by feeding a high-fat diet. Metabolism 60: 1566-1574.
    • (2011) Metabolism , vol.60 , pp. 1566-1574
    • Li, H.Q.1    Wang, B.P.2    Deng, X.L.3    Zhang, J.Y.4    Wang, Y.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.