Clostridium difficile in children: A review of existing and recently uncovered evidence

Advances in Experimental Medicine and Biology

Volumn 764, Issue , 2013, Pages 57-72

  Morris, Oliver ^a   Tebruegge, Marc ^a   Pallett, Ann ^b   Green, Steve M ^c   Pearson, Andrew D ^d   Tuck, Andrew ^a   Clarke, Stuart C ^a   Roderick, Paul ^e   Faust, Saul N ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d UNIVERSITY OF MARYLAND   (United States)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; METRONIDAZOLE; PROBIOTIC AGENT; VANCOMYCIN;

ACUTE GASTROENTERITIS; ARTICLE; ASYMPTOMATIC INFECTION; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIUM CULTURE; BACTERIUM DETECTION; CHILD HEALTH CARE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; COMMUNITY CARE; COMORBIDITY; DISEASE ASSOCIATION; ENDOTOXIN DETECTION; ENZYME IMMUNOASSAY; EVIDENCE BASED MEDICINE; FECES CULTURE; GENE; HUMAN; INFECTIOUS DIARRHEA; INTESTINE FLORA; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TCDA GENE; TCDB GENE;

EID: 84873582328     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4726-9_4     Document Type: Article

References (96)

1. (2008) National target to reduce Clostridium difficile infections: SHA envelopes. Department of Health 2. (2008) Changes to the mandatory healthcare associated infection surveillance system for Clostridium difficile infection (CDI) from 1st January 2008. Department of Health 3. Infection ACoARaHA. UK Department of Health Updated Guidance on the Diagnosis and Reporting of Clostridium difficile2012. http://www.dh.gov. uk/prod-consum-dh/groups/dh- digitalassets/@ dh/@en/documents/di gitalasset/dh-133016.pdf
2. Brazier JS (1998) The diagnosis of Clostridium difficile-associated disease. J Antimicrob Chemother 41(Suppl C):29-400
3. Delmee M (2001) Laboratory diagnosis of Clostridium difficile disease. Clin Microbiol Infect 7(8):411-4166
4. Fekety R (1997) Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 92(5):739-7500
5. Crobach MJ, Dekkers OM, Wilcox MH, Kuijper EJ (2009) European society of clinical microbiology and infectious diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect 15(12):1053-10666
6. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH (2010) Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 31(5):431-4555
7. Wilson ME (2006) Clostridium difficile and childhood diarrhea: Cause, consequence, or confounder. Clin Infect Dis 43(7):814-8166
8. McFarland LV, Brandmarker SA, Guandalini S (2000) Pediatric Clostridium difficile: A phantom menace or clinical reality? J Pediatr Gastroenterol Nutr 31(3):220-2311
9. Tang P, Roscoe M, Richardson SE (2005) Limited clinical utility of Clostridium difficile toxin testing in infants in a pediatric hospital. Diagn Microbiol Infect Dis 52(2):91-944
10. Matsuki S, Ozaki E, Shozu M, Inoue M, Shimizu S, Yamaguchi N, Karasawa T, Yamagishi T, Nakamura S (2005) Colonization by Clostridium difficile of neonates in a hospital, and infants and children in three day-care facilities of Kanazawa, Japan. Int Microbiol 8(1):43-488
11. Klein EJ, Boster DR, Stapp JR, Wells JG, Qin X, Clausen CR, Swerdlow DL, Braden CR, Tarr PI (2006) Diarrhea etiology in a Children's Hospital Emergency Department: A prospective cohort study. Clin Infect Dis 43(7):807-8133
12. Denno DM, Stapp JR, Boster DR, Qin X, Clausen CR, Del Beccaro KH, Swerdlow DL, Braden CR, Tarr PI (2005) Etiology of diarrhea in pediatric outpatient settings. Pediatr Infect Dis J 24(2):142-1488
13. Huhulescu S, Kiss R, Brettlecker M, Cerny RJ, Hess C, Wewalka G, Allerberger F (2009) Etiology of acute gastroenteritis in three sentinel general practices, Austria 2007. Infection 37(2):103-1088
14. Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DW (2006) Diarrhea in American infants and young children in the community setting: Incidence, clinical presentation and microbiology. Pediatr Infect Dis J 25(1):2-77
15. Kyne L, Warny M, Qamar A, Kelly CP (2000) Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 342(6):390-3977
16. Jangi S, Lamont JT (2010) Asymptomatic colonization by Clostridium difficile in infants: Implications for disease in later life. J Pediatr Gastroenterol Nutr 51(1):2-77
17. Niyogi SK, Dutta P, Dutta D, Mitra U, Sikdar S (1991) Clostridium difficile and its cytotoxin in hospitalized children with acute diarrhea. Indian Pediatr 28(10):1129-11322
18. Tvede M, Schiotz PO, Krasilnikoff PA (1990) Incidence of Clostridium difficile in hospitalized children. A prospective study. Acta Paediatr Scand 79(3):292-2999
19. Brook I (2005) Pseudomembranous colitis in children. J Gastroenterol Hepatol 20(2):182-1866
20. Benson L, Song X, Campos J, Singh N (2007) Changing epidemiology of Clostridium difficileassociated disease in children. Infect Control Hosp Epidemiol 28(11):1233-12355
21. Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T (2008) Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics 122(6):1266-12700
22. Pituch H (2009) Clostridium difficile is no longer just a nosocomial infection or an infection of adults. Int J Antimicrob Agents 33(Suppl 1):S42-455
23. DuPont HL, Garey K, Caeiro JP, Jiang ZD (2008) New advances in Clostridium difficile infection: Changing epidemiology, diagnosis, treatment and control. Curr Opin Infect Dis 21(5):500-5077
24. Cohen MB (2009) Clostridium difficile infections: Emerging epidemiology and new treatments. J Pediatr Gastroenterol Nutr 48(Suppl 2):S63-655
25. McFarland LV, Beneda HW, Clarridge JE, Raugi GJ (2007) Implications of the changing face of Clostridium difficile disease for health care practitioners. Am J Infect Control 35(4):237-2533
26. Walker AS, Spiegelhalter D, Crook DW, Wyllie D, Morris J, Peto TE (2008) Fairness of financial penalties to improve control of Clostridium difficile. BMJ 337:a20977
27. Goldenberg SD, Price NM, Tucker D, Wade P, French GL (2011) Mandatory reporting and improvements in diagnosing Clostridium difficile infection: An incompatible dichotomy? J Infect 62(5):363-3700
28. Lyras D, O'Connor JR, Howarth PM, Sambol SP, Carter GP, Phumoonna T, Poon R, Adams V, Vedantam G, Johnson S, Gerding DN, Rood JI (2009) Toxin B is essential for virulence of Clostridium difficile. Nature 458(7242):1176-11799
29. Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, Minton NP (2010) The role of toxin A and toxin B in Clostridium difficile infection. Nature 467(7316):711-7133
30. Drudy D, Fanning S, Kyne L (2007) Toxin A-negative, toxin B-positive Clostridium difficile. Int J Infect Dis 11(1):5-100
31. Kyne L, Farrell RJ, Kelly CP (2001) Clostridium difficile. Gastroenterol Clin North Am 30(3):753-777
32. Wilcox MH, Planche T, Fang FC, Gilligan P (2010) What is the current role of algorithmic approaches for diagnosis of Clostridium difficile infection? J Clin Microbiol. 48(12):4347-43533
33. Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeno-Tarraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J (2006) The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet 38(7):779-7866
34. Stubbs SL, Brazier JS, O'Neill GL, Duerden BI (1999) PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol 37(2):461-4633
35. Rupnik M (2001) How to detect Clostridium difficile variant strains in a routine laboratory. Clin Microbiol Infect 7(8):417-4200
36. Tenover FC, Novak-Weekley S, Woods CW, Peterson LR, Davis T, Schreckenberger P, Fang FC, Dascal A, Gerding DN, Nomura JH, Goering RV, Akerlund T, Weissfeld AS, Baron EJ, Wong E, Marlowe EM, Whitmore J, Persing DH (2010) Impact of strain type on detection of toxigenic Clostridium difficile: Comparison of molecular diagnostic and enzyme immunoassay approaches. J Clin Microbiol 48(10):3719-37244
37. Carroll KC (2011) Tests for the diagnosis of Clostridium difficile infection: The next generation. Anaerobe 17(4):170-1744
38. Wilcox MH, Planche T Defining a testing algorithm to improve the laboratory diagnosis of CDI. http://www.hpa.org.uk/webc/HPAwebFile/HPA web-C/13171329795622
39. Luna RA, Boyanton BL, Jr, Mehta S, Courtney EM, Webb CR, Revell PA, Versalovic J (2011) Rapid Stool-Based Diagnosis of Clostridium difficile Infection by Real-Time PCR in a Children's Hospital. J Clin Microbiol 49(3):851-8577
40. Wheeler JG, Sethi D, Cowden JM, Wall PG, Rodrigues LC, Tompkins DS, Hudson MJ, Roderick PJ (1999) Study of infectious intestinal disease in England: Rates in the community, presenting to general practice, and reported to national surveillance. The Infectious Intestinal Disease Study Executive. BMJ 318(7190):1046-10500
41. Sandora TJ, Fung M, Flaherty K, Helsing L, Scanlon P, Potter-Bynoe G, Gidengil CA, Lee GM (2011) Epidemiology and risk factors for Clostridium difficile infection in children. Pediatr Infect Dis J 30(7):580-5844
42. Boenning DA, Fleisher GR, Campos JM, Hulkower CW, Quinlan RW (1982) Clostridium difficile in a pediatric outpatient population. Pediatr Infect Dis 1(5):336-3388
43. Kim K, DuPont HL, Pickering LK (1983) Outbreaks of diarrhea associated with Clostridium difficile and its toxin in day-care centers: Evidence of person-to-person spread. J Pediatr 102(3):376-3822
44. Oguz F, Uysal G, Dasdemir S, Oskovi H, Vidinlisan S (2001) The role of Clostridium difficile in childhood nosocomial diarrhea. Scand J Infect Dis 33(10):731-7333
45. Rexach CE, Tang-Feldman YJ, Cantrell MC, Cohen SH (2006) Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center. Diagn Microbiol Infect Dis 56(2):109-1144
46. Pokorn M, Radsel A, Cizman M, Jereb M, Karner P, Kalan G, Grosek S, Andlovic A, Rupnik M (2008) Severe Clostridium difficile-associated disease in children. Pediatr Infect Dis J 27(10):944-9466
47. Wilson KH (1993) The microecology of Clostridium difficile. Clin Infect Dis 16(Suppl 4):S214-2188
48. Deneve C, Janoir C, Poilane I, Fantinato C, Collignon A (2009) New trends in Clostridium difficile virulence and pathogenesis. Int J Antimicrob Agents 33(Suppl 1):S24-288
49. Toltzis P, Kim J, Dul M, Zoltanski J, Smathers S, Zaoutis T (2009) Presence of the epidemic North American Pulsed Field type 1 Clostridium difficile strain in hospitalized children. J Pediatr 154(4):607-6088
50. Wongwanich S, Pongpech P, Dhiraputra C, Huttayananont S, Sawanpanyalert P (2001) Charac-teristics of Clostridium difficile strains isolated from asymptomatic individuals and from diarrheal patients. Clin Microbiol Infect 7(8):438-4411
51. Ferreira CE, Nakano V, Durigon EL, Avila-Campos MJ (2003) Prevalence of Clostridium spp. and Clostridium difficile in children with acute diarrhea in Sao Paulo city, Brazil. Mem Inst Oswaldo Cruz 98(4):451-4544
52. Karsch W, Strelau E, Grahlow WD, Fischer E, Schulz R (1989) Occurrence and significance of Clostridium difficile in faecal specimens of hospitalized children. Zentralbl Bakteriol Mikrobiol Hyg A 270(3):441-4488
53. Langley JM, LeBlanc JC, Hanakowski M, Goloubeva O (2002) The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children. Infect Control Hosp Epidemiol 23(11):660-6644
54. Al-Jumaili IJ, Shibley M, Lishman AH, Record CO (1984) Incidence and origin of Clostridium difficile in neonates. J Clin Microbiol 19(1):77-788
55. Zedd AJ, Sell TL, Schaberg DR, Fekety FR, Cooperstock MS (1984) Nosocomial Clostridium difficile reservoir in a neonatal intensive care unit. Pediatr Infect Dis 3(5):429-4322
56. Delmee M, Verellen G, Avesani V, Francois G (1988) Clostridium difficile in neonates: Serogrouping and epidemiology. Eur J Pediatr 147(1):36-400
57. Martirosian G, Kuipers S, Verbrugh H, Van Belkum A, Meisel-Mikolajczyk F (1995) PCR ribotyping and arbitrarily primed PCR for typing strains of Clostridium difficile from a Polish maternity hospital. J Clin Microbiol 33(8):2016-20211
58. el-Mohandes AE, Keiser JF, Refat M, Jackson BJ (1993) Prevalence and toxigenicity of Clostridium difficile isolates in fecal microflora of preterm infants in the intensive care nursery. Biol Neonate 63(4):225-2299
59. Enad D, Meislich D, Brodsky NL, Hurt H (1997) Is Clostridium difficile a pathogen in the newborn intensive care unit? A prospective evaluation. J Perinatol 17(5):355-3599
60. Vesikari T, Isolauri E, Maki M, Gronroos P (1984). Clostridium difficile in young children. Association with antibiotic usage. Acta Paediatr Scand 73(1):86-911
61. Zilberberg MD, Shorr AF, Kollef MH (2008) Increase in Clostridium difficile-related hospitalizations among infants in the United States, 2000-2005. Pediatr Infect Dis J 27(12):1111-11133
62. Zwiener RJ, Belknap WM, Quan R (1989) Severe pseudomembranous enterocolitis in a child: Case report and literature review. Pediatr Infect Dis J 8(12):876-8822
63. Qualman SJ, Petric M, Karmali MA, Smith CR, Hamilton SR (1990) Clostridium difficile invasion and toxin circulation in fatal pediatric pseudomembranous colitis. Am J Clin Pathol 94(4):410-4166
64. Harris PR, Figueroa-Colon R (1995) Rectal prolapse in children associated with Clostridium difficile infection. Pediatr Infect Dis J 14(1):78-800
65. Gaglani MJ, Murray JC, Morad AB, Edwards MS (1996) Chronic osteomyelitis caused by Clostridium difficile in an adolescent with sickle cell disease. Pediatr Infect Dis J 15(11):1054-10566
66. Durand CL, Miller PF (2009) Severe Clostridium difficile colitis and reactive arthritis in a 10-yearold child. Pediatr Infect Dis J 28(8):750-7511
67. Loffler HA, Pron B, Mouy R, Wulffraat NM, Prieur AM (2004) Clostridium difficile-associated reactive arthritis in two children. Joint Bone Spine 71(1):60-622
68. Clinical guideline 84 (CG84) (2009) Diarrhoea and vomiting in children under 5: Full guideline. National Institute for Health and Clinical Excellence, London 72. Singer DB, Cashore WJ, Widness JA, Campognone P, Hillemeier C (1986) Pseudomembranous colitis in a preterm neonate. J Pediatr Gastroenterol Nutr 5(2):318-3200
69. Adler SP, Chandrika T, Berman WF (1981) Clostridium difficile associated with pseudomembranous colitis. Occurrence in a 12-week-old infant without prior antibiotic therapy. Am J Dis Child 135(9):820-8222
70. Burgner D, Siarakas S, Eagles G, McCarthy A, Bradbury R, Stevens M (1997) A prospective study of Clostridium difficile infection and colonization in pediatric oncology patients. Pediatr Infect Dis J 16(12):1131-11344
71. Tullus K, Aronsson B, Marcus S, Mollby R (1989) Intestinal colonization with Clostridium difficile in infants up to 18 months of age. Eur J Clin Microbiol Infect Dis 8(5):390-3933
72. Brady MT, Pacini DL, Budde CT, Connell MJ (1989) Diagnostic studies of nosocomial diarrhea in children: Assessing their use and value. Am J Infect Control 17(2):77-822
73. Schuller I, Saha V, Lin L, Kingston J, Eden T, Tabaqchali S (1995) Investigation and management of Clostridium difficile colonisation in a paediatric oncology unit. Arch Dis Child 72(3):219-2222
74. Ferroni A, Merckx J, Ancelle T, Pron B, Abachin E, Barbut F, Larzul J, Rigault P, Berche P, Gaillard JL (1997) Nosocomial outbreak of Clostridium difficile diarrhea in a pediatric service. Eur J Clin Microbiol Infect Dis 16(12):928-9333
75. Gogate A, De A, Nanivadekar R, Mathur M, Saraswathi K, Jog A, Kulkarni MV (2005) Diagnostic role of stool culture & toxin detection in antibiotic associated diarrhoea due to Clostridium difficile in children. Indian J Med Res 122(6):518-5244
76. Pascarella F, Martinelli M, Miele E, Del Pezzo M, Roscetto E, Staiano A (2009) Impact of Clostridium difficile infection on pediatric inflammatory bowel disease. J Pediatr 154(6):854-8588
77. Markowitz JE, Brown KA, Mamula P, Drott HR, Piccoli DA, Baldassano RN (2001) Failure of single-toxin assays to detect clostridium difficile infection in pediatric inflammatory bowel disease. Am J Gastroenterol 96(9):2688-26900
78. Issa M, Ananthakrishnan AN, Binion DG (2008) Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis 14(10):1432-14422
79. Parsons SJ, Fenton E, Dargaville P (2005) Clostridium difficile associated severe enterocolitis: A feature of Hirschsprung's disease in a neonate presenting late. J Paediatr Child Health 41(12):689-6900
80. Thomas DF, Fernie DS, Bayston R, Spitz L, Nixon HH (1986) Enterocolitis in Hirschsprung's disease: A controlled study of the etiologic role of Clostridium difficile. J Pediatr Surg 21(1):22-255
81. Welkon CJ, Long SS, Thompson CM Jr. Gilligan PH (1985). Clostridium difficile in patients with cystic fibrosis. Am J Dis Child 139(8):805-8088
82. Yahav J, Samra Z, Blau H, Dinari G, Chodick G, Shmuely H (2006) Helicobacter pylori and Clostridium difficile in cystic fibrosis patients. Dig Dis Sci 51(12):2274-22799
83. Peach SL, Borriello SP, Gaya H, Barclay FE, Welch AR (1986) Asymptomatic carriage of Clostridium difficile in patients with cystic fibrosis. J Clin Pathol 39(9):1013-10188
84. Rivlin J, Lerner A, Augarten A, Wilschanski M, Kerem E, Ephros MA (1998) Severe Clostridium difficile-associated colitis in young patients with cystic fibrosis. J Pediatr 132(1):177-1799
85. Binkovitz LA, Allen E, Bloom D, Long F, Hammond S, Buonomo C, Donnelly LF 1999 Atypical presentation of Clostridium difficile colitis in patients with cystic fibrosis. AJR Am J Roentgenol 172(2):517-5211
86. Barker HC, Haworth CS, Williams D, Roberts P, Bilton D (2008) Clostridium difficile pancolitis in adults with cystic fibrosis. J Cyst Fibros 7(5):444-4477
87. Yates B, Murphy DM, Fisher AJ, Gould FK, Lordan JL, Dark JH, Corris PA (2007) Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation. Thorax 62(6):554-5566
88. Theunissen C, Knoop C, Nonhoff C, Byl B, Claus M, Liesnard C, Estenne MJ, Struelens MJ, Jacobs F (2008) Clostridium difficile colitis in cystic fibrosis patients with and without lung transplantation. Transpl Infect Dis 10(4):240-2444
89. Castagnola E, Battaglia T, Bandettini R, Caviglia I, Baldelli I, Nantron M, Moroni C, Garaventa A (2009) Clostridium difficile-associated disease in children with solid tumors. Support Care Cancer 17(3):321-3244
90. McFarland LV (2005) Alternative treatments for Clostridium difficile disease: What really works? J Med Microbiol 54(Pt 2):101-1111
91. Bauer MP, Van Dissel JT (2009) Alternative strategies for Clostridium difficile infection. Int J Antimicrob Agents 33(Suppl 1):S51-566
92. Pillai A, Nelson R (2008) Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev 23(1):CD0046111
93. McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL, Noorani Z et al (1994) A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 271(24):1913-19188
94. Bryant K, McDonald LC (2009) Clostridium difficile infections in children. Pediatr Infect Dis J 28(2):145-1466
95. Bland JM, Altman DG (2000) Statistics notes. The odds ratio. BMJ 320(7247):14688
96. Stamper PD, Alcabasa R, Aird D, Babiker W, Wehrlin J, Ikpeama I, Carroll KC (2009) Comparison of a commercial real-time PCR assay for tcdB detection to a cell culture cytotoxicity assay and toxigenic culture for direct detection of toxin-producing Clostridium difficile in clinical samples. J Clin Microbiol 47(2):373-3788