Sensitizing capacity and allergenicity of enzymatically cross-linked sodium caseinate in comparison to sodium caseinate in a mouse model for cow's milk allergy

Toxicology Letters

Volumn 218, Issue 1, 2013, Pages 50-55

  van Esch, Betty C A M ^a   Gros van Hest, Marjan ^b   Westerbeek, Hans ^b   Garssen, Johan ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b FRIESLANDCAMPINA   (Netherlands)

Author keywords

Allergenicity; Cow's milk; Cross linked caseinate; Mouse; Safety; Sensitization

Indexed keywords

CASEINATE; CROSS LINKED CASEINATE; IMMUNOGLOBULIN E; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; UNCLASSIFIED DRUG;

ALLERGENICITY; ANAPHYLACTIC SHOCK; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; MILK ALLERGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIZATION;

ALLERGENS; ANAPHYLAXIS; ANIMALS; ANTIBODIES; BODY TEMPERATURE; CASEINS; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED C3H; MILK; MILK HYPERSENSITIVITY; MILK PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSGLUTAMINASES;

EID: 84873546224     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.01.001     Document Type: Article

References (16)

1. Branum A.M., Lukacs S.L. Food allergy among U.S. children: trends in prevalence and hospitalizations. NCHS Data 2008, 10:1-8.
2. Lam H.Y., van Hoffen E., Michelsen A., Guikers K., van der Tas C.H., Bruijnzeel-Koomen C.A., Knulst A.C. Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. Clinical and Experimental Allergy 2008, 38:995-1002.
3. Levy M.B., Goldberg M.R., Nachshon L., Tabachnik E., Katz Y. Lessons from cases of mortality due to food allergy in Israel: cow's milk protein should be considered a potentially fatal allergen. Israel Medical Association Journal 2012, 14:29-33.
4. Li X.M., Schofield B.H., Huang C.K., Kleiner G.I., Sampson H.A. A murine model of IgE-mediated cow's milk hypersensitivity. Journal of Allergy and Clinical Immunology 1999, 103:206-214.
5. Lopez-Exposito I., Chicon R., Belloque J., Lopez-Fandino R., Berin M.C. In vivo methods for testing allergenicity show that high hydrostatic pressure hydrolysates of beta-lactoglobulin are immunologically inert. Journal of Dairy Science 2012, 95:541-548.
6. Pedersen M.H., Hansen T.K., Sten E., Seguro K., Ohtsuka T., Morita A., Bindslev-Jensen C., Poulsen L.K. Evaluation of the potential allergenicity of the enzyme microbial transglutaminase using the 2001 FAO/WHO Decision Tree. Molecular Nutrition and Food Research 2004, 48:434-440.
7. Schafer T., Bohler E., Ruhdorfer S., Weigl L., Wessner D., Heinrich J., Filipiak B., Wichmann H.E., Ring J. Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy. Allergy 2001, 56:1172-1179.
8. Schouten B., van Esch B.C., Hofman G.A., Boon L., Knippels L.M., Willemsen L.E., Garssen J. Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice. Journal of Nutrition 2010, 140:835-841.
9. Schouten B., van Esch B.C., Hofman G.A., Van Den Elsen L.W., Willemsen L.E., Garssen J. Acute allergic skin reactions and intestinal contractility changes in mice orally sensitized against casein or whey. International Archives of Allergy and Immunology 2008, 147:125-134.
10. Schouten B., van Esch B.C., Hofman G.A., van Doorn S.A., Knol J., Nauta A.J., Garssen J., Willemsen L.E., Knippels L.M. Cow milk allergy symptoms are reduced in mice fed dietary synbiotics during oral sensitization with whey. Journal of Nutrition 2009, 139:1398-1403.
11. Schouten B., van Esch B.C., van Thuijl A.O., Blokhuis B.R., Groot Kormelink T., Hofman G.A., Moro G.E., Boehm G., Arslanoglu S., Sprikkelman A.B., Willemsen L.E., Knippels L.M., Redegeld F.A., Garssen J. Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins. Journal of Allergy and Clinical Immunology 2010, 125:1308-1314.
12. Schulmeister U., Hochwallner H., Swoboda I., Focke-Tejkl M., Geller B., Nystrand M., Harlin A., Thalhamer J., Scheiblhofer S., Keller W., Niggemann B., Quirce S., Ebner C., Mari A., Pauli G., Herz U., Valenta R., Spitzauer S. Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen. Journal of Immunology 2009, 182:7019-7029.
13. van Esch B.C., Knipping K., Jeurink P., van der Heide S., Dubois A.E., Willemsen L.E., Garssen J., Knippels L.M. In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas. Toxicology Letters 2011, 201:264-269.
14. van Esch B.C., Schouten B., Blokhuis B.R., Hofman G.A., Boon L., Garssen J., Knippels L.M., Willemsen L.E., Redegeld F.A. Depletion of CD4+CD25+T cells switches the whey-allergic response from immunoglobulin E- to immunoglobulin free light chain-dependent. Clinical and Experimental Allergy 2010, 40:1414-1421.
15. van Esch B.C., Schouten B., Hofman G.A., van Baalen T., Nijkamp F.P., Knippels L.M., Willemsen L.E., Garssen J. Acute allergic skin response as a new tool to evaluate the allergenicity of whey hydrolysates in a mouse model of orally induced cow's milk allergy. Pediatric Allergy and Immunology 2010, 21:e780-e786.
16. van Ree R., Aalberse R.C. Specific IgE without clinical allergy. Journal of Allergy and Clinical Immunology 1999, 103:1000-1001.