Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations

PLoS Genetics

Volumn 9, Issue 1, 2013, Pages

  Bull, Katherine R ^a,b   Rimmer, Andrew J ^a   Siggs, Owen M ^a,b   Miosge, Lisa A ^c   Roots, Carla M ^c   Enders, Anselm ^c   Bertram, Edward M ^c   Crockford, Tanya L ^a,b   Whittle, Belinda ^c   Potter, Paul K ^d   Simon, Michelle M ^d   Mallon, Ann Marie ^d   Brown, Steve D M ^d   Beutler, Bruce ^e   Goodnow, Christopher C ^c   Lunter, Gerton ^a   Cornall, Richard J ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Biology and Environment   (Australia)

^d MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC ALGORITHM; GENETIC SCREENING; HAPLOTYPE; MALE; MISSENSE MUTATION; MOUSE; MUTAGENESIS; NONHUMAN;

ANIMALS; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; ETHYLNITROSOUREA; GENES, DOMINANT; GENES, RECESSIVE; GENOME; HUMANS; MICE; MUTAGENESIS; MUTATION; PHENOTYPE; SEQUENCE ANALYSIS, DNA;

EID: 84873500380     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003219     Document Type: Article

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